The Journal of Allergy and Clinical Immunology
Volume 123, Issue 2 , Pages 443-451 , February 2009

Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-γ–producing CD8+ T cells

  • Kamal D. Srivastava, MPhil

      Affiliations

    • Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
  • ,
  • Chunfeng Qu, MD, PhD

      Affiliations

    • Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
  • ,
  • Tengfei Zhang, PhD

      Affiliations

    • Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
  • ,
  • Joseph Goldfarb, PhD

      Affiliations

    • Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY
  • ,
  • Hugh A. Sampson, MD

      Affiliations

    • Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
  • ,
  • Xiu-Min Li, MD

      Affiliations

    • Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
    • Corresponding Author InformationReprint requests: Xiu-Min Li, MD, Pediatric Allergy and Immunology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574.

Received 29 October 2008 ,Revised 19 December 2008 ,Accepted 22 December 2008.

References 

  1. O'Connell EJ. The burden of atopy and asthma in children. Allergy. 2004;59(suppl 78):7–11
  2. Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health Organ. 2005;83:548–554
  3. Isolauri E, Huurre A, Salminen S, Impivaara O. The allergy epidemic extends beyond the past few decades. Clin Exp Allergy. 2004;34:1007–1010
  4. Wang J, Sampson HA. Food anaphylaxis. Clin Exp Allergy. 2007;37:651–660
  5. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol. 2001;107:191–193
  6. Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327:380–384
  7. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207
  8. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491–503
  9. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99:744–751
  10. Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DY. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol. 1992;90:256–262
  11. Leung DY, Sampson HA, Yunginger JW, Burks AWJ, Schneider LC, Wortel CH, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med. 2003;348:986–993
  12. Li XM, Zhang TF, Huang CK, Srivastava K, Teper AA, Zhang L, et al. Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol. 2001;108:639–646
  13. Srivastava KD, Kattan JD, Zou ZM, Li JH, Zhang L, Wallenstein S, et al. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J Allergy Clin Immunol. 2005;115:171–178
  14. Kattan JD, Srivastava KD, Zou ZM, Goldfarb J, Sampson HA, Li XM. Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy. Phytother Res. 2008;22:651–659
  15. Qu C, Srivastava K, Ko J, Zhang TF, Sampson HA, Li XM. Induction of tolerance after establishment of peanut allergy by the food allergy herbal formula-2 is associated with up-regulation of interferon-gamma. Clin Exp Allergy. 2007;37:846–855
  16. The State Pharmacopoeia Commission of the People's Republic of China . Pharmacopoeia of the People's Republic of China. 6th ed.. Beijing: People's Medical Publishing House; 2005;
  17. The US Food and Drug Administration (FDA), Center for Drug Evaluation and Research. Guidance for industry botanical drug products. Revised ed. Rockville (MD):2004.
  18. Li XM, Schofield BH, Huang CK, Kleiner GA, Sampson HA. A murine model of IgE mediated cow milk hypersensitivity. J Allergy Clin Immunol. 1999;103:206–214
  19. Li XM, Zhang TF, Huang CK, Srivastava K, Teper AA, Zhang L, et al. Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol. 2001;108:639–646
  20. Williams RO, Williams DG, Feldmann M, Maini RN. Increased limb involvement in murine collagen-induced arthritis following treatment with anti-interferon-gamma. Clin Exp Immunol. 1993;92:323–327
  21. Harty JT, Schreiber RD, Bevan MJ. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc Natl Acad Sci U S A. 1992;89:11612–11616
  22. Arora S, McDonald RA, Toews GB, Huffnagle GB. Effect of a CD4-depleting antibody on the development of Cryptococcus neoformans-induced allergic bronchopulmonary mycosis in mice. Infect Immun. 2006;74:4339–4348
  23. Primeau MN, Kagan R, Joseph L, Lim H, Dufresne C, Duffy C, et al. The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy. 2000;30:1135–1143
  24. Saini SS, MacGlashan DW, Sterbinsky SA, Togias A, Adelman DC, Lichtenstein LM, et al. Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J Immunol. 1999;162:5624–5630
  25. Strait RT, Morris SC, Finkelman FD. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest. 2006;116:833–841
  26. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991;12:256–257
  27. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol. 2000;105:399–408
  28. Netea MG, Kullberg BJ, van der Meer JW. Severely impaired IL-12/IL-18/IFNgamma axis in patients with hyper IgE syndrome. Eur J Clin Invest. 2005;35:718–721
  29. Pene J, Guglielmi L, Gauchat JF, Harrer N, Woisetschlager M, Boulay V, et al. IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene. J Immunol. 2006;177:5006–5013
  30. Lewkowich IP, Hayglass KT. Endogenous IFN-gamma and IL-18 production directly limit induction of type 2 immunity in vivo. Eur J Immunol. 2002;32:3536–3545
  31. MacDonald TT, Pettersson S. Bacterial regulation of intestinal immune responses. Inflamm Bowel Dis. 2000;6:116–122
  32. Hauer AC, Bajaj-Elliott M, Williams CB, J.A. , MacDonald TT. An analysis of interferon gamma, IL-4, IL-5 and IL-10 production by ELISPOT and quantitative reverse transcriptase-PCR in human Peyer's patches. Cytokine. 1998;10:627–634
  33. Nagata S, McKenzie C, Pender SL, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, et al. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J Immunol. 2000;165:5315–5321
  34. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol. 2003;33:1205–1214
  35. Thomas MJ, Noble A, Sawicka E, Askenase PW, Kemeny DM. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation 30. J Immunol. 2002;168:216–223
  36. Salagianni M, Wong KL, Thomas MJ, Noble A, Kemeny DM. An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses. J Immunol. 2007;178:4771–4778
  37. Wells JW, Cowled CJ, Giorgini A, Kemeny DM, Noble A. Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration. J Allergy Clin Immunol. 2007;119:226–234
  38. Kirshenbaum AS, Worobec AS, Davis TA, Goff JP, Semere T, Metcalfe DD. Inhibition of human mast cell growth and differentiation by interferon gamma-1b. Exp Hematol. 1998;26:245–251

 Supported by the Food Allergy Initiative and by National Institutes of Health grant #AT001495-01A1 awarded to X.-M.L.

 Disclosure of potential conflict of interest: X.-M. Li has received research support from the National Institutes of Health/National Center for Complementary and Alternative Medicine and the Food Allergy Initiative; has provided legal consultation or expert witness testimony on the topic of food allergy; and shares a patent for Food Allergy Herbal Formula-2 with Herbal Springs, LLC. H. A. Sampson received research support from the National Institutes of Health/National Center for Complementary and Alternative Medicine and the Food Allergy Initiative; is a consultant/scientific advisor for the Food Allergy Initiative and president of the American Academy of Allergy, Asthma and Immunology; and is part-owner of Herbal Springs, LLC. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)03467-2

doi: 10.1016/j.jaci.2008.12.1107

The Journal of Allergy and Clinical Immunology
Volume 123, Issue 2 , Pages 443-451 , February 2009