The Journal of Allergy and Clinical Immunology
Volume 123, Issue 1 , Pages 35-40 , January 2009

Advances in adult asthma diagnosis and treatment and health outcomes, education, delivery, and quality in 2008

  • Andrea J. Apter, MD, MSc

      Affiliations

    • Corresponding Author InformationReprint requests: Andrea J. Apter, MD, MSc, 829 Gates Building, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104.

Received 18 November 2008 ,Accepted 19 November 2008.

References 

  1. Apter AJ. Clinical advances in adult asthma. J Allergy Clin Immunol. 2003;111:S780–S784
  2. Apter AJ. Advances in adult asthma 2006: its risk factors, course, and management. J Allergy Clin Immunol. 2007;119:563–566
  3. Apter AJ. Advances in the care of adults with asthma and allergy in 2007. J Allergy Clin Immunol. 2008;121:839–844
  4. Apter AJ, Szefler SJ. Advances in adult and pediatric asthma. J Allergy Clin Immunol. 2004;113:407–414
  5. Apter AJ, Szefler SJ. Advances in adult and pediatric asthma. J Allergy Clin Immunol. 2006;117:512–518
  6. Szefler SJ, Apter A. Advances in pediatric and adult asthma. J Allergy Clin Immunol. 2005;115:470–477
  7. Pedersen S, O'Byrne PM. Exhaled nitric oxide in guideline-based asthma management. Lancet. 2008;372:1015–1017
  8. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, et al. Endogenous airway acidification: implications for asthma pathophysiology. Am J Respir Crit Care Med. 2000;161:694–699
  9. Hauswirth DW, Sundy JS, Mervin-Blake S, Fernandez CA, Patch KB, Alexander KM, et al. Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African Americans. J Allergy Clin Immunol. 2008;122:101–106
  10. Gaston B, Kelly R, Urban P, Liu L, Henderson EM, Doctor A, et al. Buffering airway acid decreases exhaled nitric oxide in asthma. J Allergy Clin Immunol. 2006;118:817–822
  11. Shin HW, Shelley DA, Henderson EM, Fitzpatrick A, Gaston B, George SC. Airway nitric oxide release is reduced after PBS inhalation in asthma. J Appl Physiol. 2007;102:1028–1033
  12. Craig TJ, King TS, Lemanske RF, Wechsler ME, Icitovic N, Zimmerman RR, et al. Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma. J Allergy Clin Immunol. 2008;121:671–677
  13. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008;372:1065–1072
  14. Expert Panel Report 3: guidelines for the diagnosis and management of asthma, full report 2007. Bethesda (MD): US Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute; 2007;
  15. Levesque MC, Hauswirth DW, Mervin-Blake S, Fernandez CA, Patch KB, Alexander KM, et al. Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults. J Allergy Clin Immunol. 2008;121:396–402e3
  16. Park SS, Grayson MH. Clinical research: protection of the “vulnerable”. J Allergy Clin Immunol. 2008;121:1103–1107
  17. Romieu I, Barraza-Villarreal A, Escamilla-Nunez C, Almstrand AC, Diaz-Sanchez D, Sly PD, et al. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J Allergy Clin Immunol. 2008;121:903–909e6
  18. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002;418:426–430
  19. Tantisira KG, Silverman ES, Mariani TJ, Xu J, Richter BG, Klanderman BJ, et al. FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. J Allergy Clin Immunol. 2007;120:1285–1291
  20. Tantisira KG, Lazarus R, Litonjua AA, Klanderman B, Weiss ST. Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma. Pharmacogenet Genomics. 2008;18:733–737
  21. Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, et al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008;178:688–694
  22. Raby BA, Silverman EK, Kwiatkowski DJ, Lange C, Lazarus R, Weiss ST. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004;113:1071–1078
  23. Dijkstra A, Koppelman GH, Vonk JM, Bruinenberg M, Schouten JP, Postma DS. Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms. J Allergy Clin Immunol. 2008;121:1510–1513
  24. Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol. 2008;121:860–863
  25. Hendeles L, Colice GL, Meyer RJ. Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants. N Engl J Med. 2007;356:1344–1351
  26. Evolution of the Montreal Protocol. United Nations Environmental Programme, 2007. Available at: http://ozone.unep.org/Ratification_Status/evolution_of_mp.html. Accessed December 9, 2008.
  27. Leo HL, Dombkowski KJ, Clark NM. The economic effect of the hydrofluoroalkane albuterol transition on children with asthma. J Allergy Clin Immunol. 2008;121:776–777
  28. National Assessment of Adult Literacy. Washington (DC): National Center for Education Statistics, Institute of Education Sciences, US Department of Education; 2003;
  29. Smith H, Wade J, Frew A. How readable are the American Academy of Allergy, Asthma & Immunology “Tips to Remember” leaflets?. J Allergy Clin Immunol. 2008;121:770–773
  30. In:  Nielson-Bohlman L,  Panzer A,  Kindig D editor. Health literacy: a prescription to end confusion. Washington (DC): National Academies Press; 2004;
  31. Parikh NS, Parker RM, Nurss JR, Baker DW, Williams MV. Shame and health literacy: the unspoken connection. Patient Educ Couns. 1996;27:33–39
  32. Weiss BD, Coyne C. Communicating with patients who cannot read. N Engl J Med. 1997;337:272–274
  33. Unequal treatment: confronting racial and ethnic disparities in health care. Washington (DC): Institute of Medicine, National Academies Press; 2003;
  34. Apter AJ, Cheng J, Small D, Bennett IM, Albert C, Fein D, et al. Asthma numeracy skill and health literacy. J Asthma. 2006;43:705–710
  35. Paasche-Orlow MK, Riekert KA, Bilderback A, Chanmugam A, Hill P, Rand CS, et al. Tailored education may reduce health literacy disparities in asthma self-management. Am J Respir Crit Care Med. 2005;172:980–986
  36. Williams MV, Baker DW, Honig EG, Lee TM, Nowlan A. Inadequate literacy is a barrier to asthma knowledge and self-care. Chest. 1998;114:1008–1015
  37. Apter AJ, Paasche-Orlow MK, Remillard JT, Bennett IM, Ben-Joseph EP, Batista RM, et al. Numeracy and communication with patients: they are counting on us. J Gen Intern Med. 2008;Oct 2 [epub ahead of print]
  38. Juniper EF, Guyatt GH, Cox FM, Ferrie PJ, King DR. Development and validation of the Mini Asthma Quality of Life Questionnaire. Eur Respir J. 1999;14:32–38
  39. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65
  40. Vollmer WM, Markson LE, O'Connor E, Frazier EA, Berger M, Buist AS. Association of asthma control with health care utilization: a prospective evaluation. Am J Respir Crit Care Med. 2002;165:195–199
  41. Skinner EA, Diette GB, Algatt-Bergstrom PJ, Nguyen TT, Clark RD, Markson LE, et al. The Asthma Therapy Assessment Questionnaire (ATAQ) for children and adolescents. Dis Manag. 2004;7:305–313
  42. Patino CM, Okelo SO, Rand CS, Riekert KA, Krishnan JA, Thompson K, et al. The Asthma Control and Communication Instrument: a clinical tool developed for ethnically diverse populations. J Allergy Clin Immunol. 2008;122:936–943
  43. Juniper EF, Schatz M, Juniper BA, Zeiger RS. Evaluation of 2 interactive voice-response telephone versions of health-related quality-of-life questionnaires. J Allergy Clin Immunol. 2008;122:654–655
  44. Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR. Validation of a standardized version of the Asthma Quality of Life Questionnaire. Chest. 1999;115:1265–1270
  45. Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Development and validation of the mini Rhinoconjunctivitis Quality of Life Questionnaire. Clin Exp Allergy. 2000;30:132–140
  46. Marsden PA, Smith JA, Kelsall AA, Owen E, Naylor JR, Webster D, et al. A comparison of objective and subjective measures of cough in asthma. J Allergy Clin Immunol. 2008;122:903–907
  47. Blais L, Forget A. Asthma exacerbations during the first trimester of pregnancy and the risk of congenital malformations among asthmatic women. J Allergy Clin Immunol. 2008;121:1379–1384e1
  48. Mosen DM, Schatz M, Magid DJ, Camargo CA. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008;122:507–511e6
  49. Litonjua AA, Gold DR. Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol. 2008;121:1075–1084quiz 85-6
  50. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121:1087–1093quiz 94-5
  51. Mehra R, Redline S. Sleep apnea: a proinflammatory disorder that coaggregates with obesity. J Allergy Clin Immunol. 2008;121:1096–1102
  52. Moorman JE, Rudd RA, Johnson CA, King M, Minor P, Bailey C, et al. National surveillance for asthma—United States, 1980-2004. MMWR Surveill Summ. 2007;56:1–54
  53. Ginde AA, Espinola JA, Camargo CA. Improved overall trends but persistent racial disparities in emergency department visits for acute asthma, 1993-2005. J Allergy Clin Immunol. 2008;122:313–318
  54. Miller TP, Oswald FL, Reeves MJ. An exploration of factors underlying asthma care and morbidity: a factor analysis of clinical variables. J Allergy Clin Immunol. 2008;122:328–334e1-5
  55. Riekert KA, Eakin M. Factor analysis: a primer for asthma researchers. J Allergy Clin Immunol. 2008;121:1181–1183
  56. O'Connor GT, Neas L, Vaughn B, Kattan M, Mitchell H, Crain EF, et al. Acute respiratory health effects of air pollution on children with asthma in US inner cities. J Allergy Clin Immunol. 2008;121:1133–1139e1
  57. Rand CS, Apter AJ. Mind the widening gap: have improvements in asthma care increased asthma disparities?. J Allergy Clin Immunol. 2008;122:319–321
  58. Taylor DR, Hannah D. Management of beta-agonist overuse: why and how?. J Allergy Clin Immunol. 2008;122:836–838
  59. Cooper PR, Panettieri RA. Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol. 2008;122:734–740
  60. Zeiger RS, Hay JW, Contreras R, Chen W, Quinn VP, Seal B, et al. Asthma costs and utilization in a managed care organization. J Allergy Clin Immunol. 2008;121:885–892e5
  61. Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, et al. Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005;352:1519–1528
  62. Busse WW, Shah SR, Somerville L, Parasuraman B, Martin P, Goldman M. Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients. J Allergy Clin Immunol. 2008;121:1407–1414e1-6
  63. Juhn YJ, Kita H, Yawn BP, Boyce TG, Yoo KH, McGree ME, et al. Increased risk of serious pneumococcal disease in patients with asthma. J Allergy Clin Immunol. 2008;122:719–723
  64. Talbot TR, Hartert TV, Mitchel E, Halasa NB, Arbogast PG, Poehling KA, et al. Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med. 2005;352:2082–2090
  65. Hartert TV. Are persons with asthma at increased risk of pneumococcal infections, and can we prevent them?. J Allergy Clin Immunol. 2008;122:724–725
  66. Barr RG, Kurth T, Stampfer MJ, Buring JE, Hennekens CH, Gaziano JM. Aspirin and decreased adult-onset asthma: randomized comparisons from the Physicians' Health Study. Am J Respir Crit Care Med. 2007;175:120–125
  67. Barr RG, Wentowski CC, Curhan GC, Somers SC, Stampfer MJ, Schwartz J, et al. Prospective study of acetaminophen use and newly diagnosed asthma among women. Am J Respir Crit Care Med. 2004;169:836–841
  68. Menzies D, Nair A, Meldrum KT, Hopkinson P, Lipworth BJ. Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. J Allergy Clin Immunol. 2008;121:1184–1189e4
  69. Shaker M, Lobb A, Jenkins P, O'Rourke D, Takemoto SK, Sheth S, et al. An economic analysis of aspirin desensitization in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2008;121:81–87
  70. The new drug development process. In: Center for Drug Evaluation and Research USFaDA, ed. Rockville (MD): 2008. Available at: http://www.fda.gov/CDER/HANDBOOK/DEVELOP.htm. Accessed December 5, 2008.
  71. Early communication about an ongoing safety review of montelukast (Singulair). Rockville (MD): Center for Drug Evaluation and Research, US Food and Drug Administration; 2008;
  72. Holbrook JT, Harik-Khan R. Montelukast and emotional well-being as a marker for depression: Results from 3 randomized, double-masked clinical trials. J Allergy Clin Immunol. 2008;122:828–829
  73. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Qual Life Res. 1996;5:35–46
  74. Radloff LS. The CES-D Scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401
  75. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36), I: conceptual framework and item selection. Med Care. 1992;30:473–483
  76. Limb SL, Starke PR, Lee CE, Chowdhury BA. Delayed onset and protracted progression of anaphylaxis after omalizumab administration in patients with asthma. J Allergy Clin Immunol. 2007;120:1378–1381
  77. Barry PJ, O'Mahony A, Finnegan C, O'Connor TM. Delayed allergic reactions to omalizumab: are patients reporting all cases?. J Allergy Clin Immunol. 2008;121:785–786author reply 6
  78. Limb SL, Lee CE, Starke PR, Chowdhury BA. Reply. J Allergy Clin Immunol. 2008;121:786
  79. Cresswell KM, Sheikh A. Information technology-based approaches to reducing repeat drug exposure in patients with known drug allergies. J Allergy Clin Immunol. 2008;121:1112–1117e7
  80. Rayens MK, Burkhart PV, Zhang M, Lee S, Moser DK, Mannino D, et al. Reduction in asthma-related emergency department visits after implementation of a smoke-free law. J Allergy Clin Immunol. 2008;122:537–541e3
  81. Rabinovitch N. Smoky, and they banned it!. J Allergy Clin Immunol. 2008;122:542–543
  82. Kumar R, Curtis LM, Khiani S, Moy J, Shalowitz M, Sharp L, et al. A community-based study of tobacco smoke exposure among inner-city children with asthma in Chicago. J Allergy Clin Immunol. 2008;122:754–759
  83. Salo PM, Arbes SJ, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol. 2008;121:678–684e2
  84. Hunninghake GM, Soto-Quiros ME, Lasky-Su J, Avila L, Ly NP, Liang C, et al. Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol. 2008;122:93–98e1-5

 Supported by the National Heart, Lung, and Blood Institute (HL073932, HL088469).

 Disclosure of potential conflict of interest: A. Apter has received grant support from the National Heart, Lung, and Blood Institute.

PII: S0091-6749(08)02209-4

doi: 10.1016/j.jaci.2008.11.017

The Journal of Allergy and Clinical Immunology
Volume 123, Issue 1 , Pages 35-40 , January 2009

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