The Journal of Allergy and Clinical Immunology
Volume 122, Issue 6 , Pages 1145-1153.e3 , December 2008

Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis

  • Moshe Yamin, PhD

      Affiliations

    • Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
    • ,
  • Eric H. Holbrook, MD

      Affiliations

    • Massachusetts Eye and Ear Infirmary, Boston, Mass
    • ,
  • Stacey T. Gray, MD

      Affiliations

    • Massachusetts Eye and Ear Infirmary, Boston, Mass
    • ,
  • Rachel Harold, BA

      Affiliations

    • Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
    • ,
  • Nicolas Busaba, MD

      Affiliations

    • Massachusetts Eye and Ear Infirmary, Boston, Mass
    • ,
  • Avinash Sridhar

      Affiliations

    • Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
    • ,
  • Katia J. Powell, BS

      Affiliations

    • Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
    • ,
  • Daniel L. Hamilos, MD

      Affiliations

    • Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
    • Corresponding Author InformationReprint requests: Daniel L. Hamilos, MD, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, 55 Fruit Street, Bulfinch-422, Boston, MA 02114.

Received 19 February 2008 ,Revised 15 September 2008 ,Accepted 19 September 2008.

References 

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 Supported by a grant from the Flight Attendants Medical Research Institute.

 Disclosure of potential conflict of interest: D. L. Hamilos has received honoraria from Merck, Critical Therapeutics, Genentech, and Novartis; has consulting arrangements with GlaxoSmithKline, Novartis, Accentia, Schering-Plough, and Sinexus; has received research support from the Flight Attendants Medical Research Institute and Merck; and has received gifts from the GG Monks Foundation to purchase equipment. E. H. Holbrook has received research support from the National Institutes of Health-National Institutes of Deafness and Other Communication Disorders. S. T. Gray has served as a member of the American Academy of Otolaryngology and the American Rhinologic Society. N. Busaba is on the speakers' bureau for Sanofi-Aventis and Schering-Plough. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01728-4

doi: 10.1016/j.jaci.2008.09.033

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 6 , Pages 1145-1153.e3 , December 2008

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