The Journal of Allergy and Clinical Immunology
Volume 122, Issue 5 , Pages 984-991 , November 2008

Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy

  • George Du Toit, FRCPCH

      Affiliations

    • King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
    • ,
  • Yitzhak Katz, MD, PhD

      Affiliations

    • Allergy and Immunology Institute, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Peter Sasieni, PhD

      Affiliations

    • Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine, London, United Kingdom
    • ,
  • David Mesher, MSc

      Affiliations

    • Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine, London, United Kingdom
    • ,
  • Soheila J. Maleki, PhD

      Affiliations

    • US Department of Agriculture, Agricultural Research Service, Southern Regional Research Center (SRRC), New Orleans, La
    • ,
  • Helen R. Fisher, BSc

      Affiliations

    • King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
    • ,
  • Adam T. Fox, FRCPCH

      Affiliations

    • King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
    • ,
  • Victor Turcanu, MD, PhD

      Affiliations

    • King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
    • ,
  • Tal Amir

      Affiliations

    • Israel Institute of Technology, Haifa, Israel
    • ,
  • Galia Zadik-Mnuhin, MD

      Affiliations

    • Allergy and Immunology Institute, Assaf Harofeh Medical Center, Tel Aviv, Israel
    • ,
  • Adi Cohen, MD

      Affiliations

    • Allergy and Immunology Institute, Assaf Harofeh Medical Center, Tel Aviv, Israel
    • ,
  • Irit Livne, MD

      Affiliations

    • School of Health and Health Education, Jerusalem, Israel
    • ,
  • Gideon Lack, FRCPCH

      Affiliations

    • King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
    • Corresponding Author InformationReprint requests: Gideon Lack, FRCPCH, Kings College London, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Lambeth Palace Rd, London, United Kingdom SE1 7EH.

Received 30 June 2008 ,Revised 20 August 2008 ,Accepted 25 August 2008.

References 

  1. Hourihane JO, Aiken R, Briggs R, Gudgeon LA, Grimshaw KE, DunnGalvin A, et al. The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry. J Allergy Clin Immunol. 2007;119:1197–1202
  2. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207
  3. Fleischer DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. The natural progression of peanut allergy: resolution and the possibility of recurrence. J Allergy Clin Immunol. 2003;112:183–189
  4. Hourihane JO, Roberts SA, Warner JO. Resolution of peanut allergy: case-control study. BMJ. 1998;316:1271–1275
  5. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol. 2001;107:191–193
  6. Moneret-Vautrin DA, Morisset M, Flabbee J, Beaudouin E, Kanny G. Epidemiology of life-threatening and lethal anaphylaxis: a review. Allergy. 2005;60:443–451
  7. Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327:380–384
  8. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT). Adverse reactions to food and food ingredients. London (United Kingdom): Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment. 1998;11;91-7
  9. American Academy of Pediatrics Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics. 2000;106:346–349
  10. Greer FR, Sicherer SH, Burks AW. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008;121:183–191
  11. Prescott SL, Tang ML. The Australasian Society of Clinical Immunology and Allergy position statement: summary of allergy prevention in children. Med J Aust. 2005;182:464–467
  12. Zeiger RS, Heller S. The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol. 1995;95:1179–1190
  13. Khakoo A, Lack G. Preventing food allergy. Curr Allergy Asthma Rep. 2004;4:36–42
  14. Høst A, Halken S, Muraro A, Dreborg S, Niggemann B, Aalberse R, et al. Dietary prevention of allergic diseases in infants and small children. Pediatr Allergy Immunol. 2008;19:1–4
  15. Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol. 2008;121:1331–1336
  16. Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med. 2003;348:977–985
  17. Hill DJ, Heine RG, Hosking CS, Brown J, Thiele L, Allen KJ, et al. IgE food sensitization in infants with eczema attending a dermatology department. J Pediatr. 2007;151:359–363
  18. Fox AT, Lack G. High environmental exposure to peanut in infancy as a risk factor for peanut allergy. J Allergy Clin Immunol. 2005;115(suppl):34
  19. Perry TT, Conover-Walker MK, Pomes A, Chapman MD, Wood RA. Distribution of peanut allergen in the environment. J Allergy Clin Immunol. 2004;113:973–976
  20. Maloney JM, Chapman MD, Sicherer SH. Peanut allergen exposure through saliva: assessment and interventions to reduce exposure. J Allergy Clin Immunol. 2006;118:719–724
  21. Dybendal T, Elsayed S. Dust from carpeted and smooth floors. VI. Allergens in homes compared with those in schools in Norway. Allergy. 1994;49:210–216
  22. Witteman AM, van LJ, van der ZJ, Aalberse RC. Food allergens in house dust. Int Arch Allergy Immunol. 1995;107:566–568
  23. Strid J, Thomson M, Hourihane J, Kimber I, Strobel S. A novel model of sensitization and oral tolerance to peanut protein. Immunology. 2004;113:293–303
  24. Frossard CP, Hauser C, Eigenmann PA. Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. J Allergy Clin Immunol. 2004;114:377–382
  25. Marth T, Strober W, Kelsall BL. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J Immunol. 1996;157:2348–2357
  26. Kerosuo H, Kullaa A, Kerosuo E, Kanerva L, Hensten-Pettersen A. Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears. Am J Orthod Dentofacial Orthop. 1996;109:148–154
  27. Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Derm Venereol. 2002;82:359–364
  28. Twarog FJ, Weinstein SF, Khaw KT, Strieder DJ, Colten HR. Hypersensitivity to pancreatic extracts in parents of patients with cystic fibrosis. J Allergy Clin Immunol. 1977;59:35–40
  29. Poole JA, Barriga K, Leung DY, Hoffman M, Eisenbarth GS, Rewers M, et al. Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics. 2006;117:2175–2182
  30. Green R, Luyt D. Clinical characteristics of childhood asthmatics in Johannesburg. S Afr Med J. 1997;87:878–882
  31. Hill DJ, Hosking CS, Heine RG. Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment. Ann Med. 1999;31:272–281
  32. Lee B, Shek L, Gerez I, Soh S, Van Bever H. Food allergy—lessons From Asia. World Allergy Org J. 2008;1:129–133
  33. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–743
  34. Strachan DP. Family size, infection and atopy: the first decade of the “hygiene hypothesis. Thorax. 2000;55(suppl 1):S2–S10
  35. Eder W, Ege MJ, von ME. The asthma epidemic. N Engl J Med. 2006;355:2226–2235
  36. Fox AT, Meyer R, Du Toit G, Syed H, Sasieni P, Lack G. Retrospective recall of maternal peanut consumption using a multiple food-frequency questionnaire. S Afr J Clin Nutr. 2006;19:110–115
  37. Roberts G, Lack G. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol. 2005;115:1291–1296
  38. Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113:805–819
  39. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30:1540–1546
  40. Department of Health, 1998. Peanut Allergy Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment. Washington (DC): US Department of Health; 1998;p. 35-7
  41. Maleki SJ, Chung SY, Champagne ET, Raufman JP. The effects of roasting on the allergenic properties of peanut proteins. J Allergy Clin Immunol. 2000;106:763–768
  42. Dalal I, Binson I, Reifen R, Amitai Z, Shohat T, Rahmani S, et al. Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel. Allergy. 2002;57:362–365
  43. Beyer K, Bardina L, Grishina G, Sampson HA. Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens. J Allergy Clin Immunol. 2002;110:154–159
  44. Pastorello EA, Varin E, Farioli L, Pravettoni V, Ortolani C, Trambaioli C, et al. The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin. J Chromatogr B Biomed Sci Appl. 2001;756:85–93
  45. Hourihane JO, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ. 1996;313:518–521
  46. Emmett SE, Angus FJ, Fry JS, Lee PN. Perceived prevalence of peanut allergy in Great Britain and its association with other atopic conditions and with peanut allergy in other household members. Allergy. 1999;54:380–385
  47. Mullins RJ. Paediatric food allergy trends in a community-based specialist allergy practice, 1995-2006. Med J Aust. 2007;186:618–621

 Supported by a research grant from the National Peanut Board, United States. This grant supported the project costs, including the salary of G.D.T. over the study duration. G.L.'s salary was in part supported by the Aimwell Foundation. Support was also provided by the Department of Health via the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London.

 Disclosure of potential conflict of interest: G. Du Toit has received research support from the Immune Tolerance Network and the National Peanut Board, United States. Y. Katz has received research support from the Israel Dairy Board and has provided legal consultation or expert witness testimony on the subject of milk exposure. S. J. Maleki has received research support from the Georgia Peanut Commission. V. Turcanu has received research support from the Food Standards Agency (UK), the National Peanut Board, United States, the Immune Tolerance Network, and the Food Allergy and Anaphylaxis Network. G. Lack has consulted for the advisory boards of Synovate, Novartis-Xolair, and ALK-Abelló; has given lectures supported by SHS Nutricia, SHS International, and Nestlé; has received research support from the Immune Tolerance Network, the National Peanut Board, United States, the Food Standard Agency, the Food Allergy Initiative, the Food Allergy and Anaphylaxis Network, and the Medical Research Council; and has served as a scientific advisor for the Anaphylaxis Campaign and the National Peanut Board, United States. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01698-9

doi: 10.1016/j.jaci.2008.08.039

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 5 , Pages 984-991 , November 2008

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