« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 122, Issue 5 , Pages 984-991 , November 2008

Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy

George Du Toit, FRCPCH
- King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Yitzhak Katz, MD, PhD
- Allergy and Immunology Institute, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Peter Sasieni, PhD
- Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine, London, United Kingdom
David Mesher, MSc
- Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine, London, United Kingdom
Soheila J. Maleki, PhD
- US Department of Agriculture, Agricultural Research Service, Southern Regional Research Center (SRRC), New Orleans, La
Helen R. Fisher, BSc
- King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Adam T. Fox, FRCPCH
- King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Victor Turcanu, MD, PhD
- King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Tal Amir
- Israel Institute of Technology, Haifa, Israel
Galia Zadik-Mnuhin, MD
- Allergy and Immunology Institute, Assaf Harofeh Medical Center, Tel Aviv, Israel
Adi Cohen, MD
- Allergy and Immunology Institute, Assaf Harofeh Medical Center, Tel Aviv, Israel
Irit Livne, MD
- School of Health and Health Education, Jerusalem, Israel
Gideon Lack, FRCPCH
- King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
- Reprint requests: Gideon Lack, FRCPCH, Kings College London, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Lambeth Palace Rd, London, United Kingdom SE1 7EH.

Received 30 June 2008 ,Revised 20 August 2008 ,Accepted 25 August 2008.

Kaplan-Meier estimates for age at which foods are introduced and duration of breast-feeding and exclusive breast-feeding according to country. ^∗The y-axis represents proportions who have consumed food

Kaplan-Meier estimates for age at which foods are introduced and duration of breast-feeding and exclusive breast-feeding according to country. ^∗The y-axis represents proportions who have consumed food by age (in months). ^∗∗The y-axis represents the proportion still breast-feeding/exclusively breast-feeding at various ages (in months). P values are derived by using the log-rank test.
- Full-Size Image
- Download to PowerPoint
Major allergen content and IgE binding of peanut foods in the UK and Israel. Slot-blot analysis of Israeli peanut snacks and 2 commonly consumed peanut butters from the UK is shown. Serial dilutions o

Major allergen content and IgE binding of peanut foods in the UK and Israel. Slot-blot analysis of Israeli peanut snacks and 2 commonly consumed peanut butters from the UK is shown. Serial dilutions of peanut protein from each food can be seen from the highest dilution (lane 1) through the lowest dilution (lane 6). Each of 4 membranes was probed with either anti-Ara h 1 (Anti-A1), anti-Ara h 2 (Anti-A2), or anti-Ara h 3 (Anti-A3) or a pool of 9 patient sera IgE from individuals with PA.
- Full-Size Image
- Download to PowerPoint

Supported by a research grant from the National Peanut Board, United States. This grant supported the project costs, including the salary of G.D.T. over the study duration. G.L.'s salary was in part supported by the Aimwell Foundation. Support was also provided by the Department of Health via the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London.

Disclosure of potential conflict of interest: G. Du Toit has received research support from the Immune Tolerance Network and the National Peanut Board, United States. Y. Katz has received research support from the Israel Dairy Board and has provided legal consultation or expert witness testimony on the subject of milk exposure. S. J. Maleki has received research support from the Georgia Peanut Commission. V. Turcanu has received research support from the Food Standards Agency (UK), the National Peanut Board, United States, the Immune Tolerance Network, and the Food Allergy and Anaphylaxis Network. G. Lack has consulted for the advisory boards of Synovate, Novartis-Xolair, and ALK-Abelló; has given lectures supported by SHS Nutricia, SHS International, and Nestlé; has received research support from the Immune Tolerance Network, the National Peanut Board, United States, the Food Standard Agency, the Food Allergy Initiative, the Food Allergy and Anaphylaxis Network, and the Medical Research Council; and has served as a scientific advisor for the Anaphylaxis Campaign and the National Peanut Board, United States. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01698-9

doi: 10.1016/j.jaci.2008.08.039

« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 122, Issue 5 , Pages 984-991 , November 2008