The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 741-747.e4 , October 2008

Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children

  • Ronina A. Covar, MD

      Affiliations

    • Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colo
    • Corresponding Author InformationReprint requests: Ronina A. Covar, MD, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206.
    • ,
  • Stanley J. Szefler, MD

      Affiliations

    • Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colo
    • ,
  • Robert S. Zeiger, MD, PhD

      Affiliations

    • Department of Pediatrics, University of California San Diego, and the Department of Allergy, Kaiser Permanente, San Diego, Calif
    • ,
  • Christine A. Sorkness, PharmD

      Affiliations

    • Clinical Science Center, University of Wisconsin, and the Department of Pediatrics, University of California-San Diego, San Diego, Calif
    • ,
  • Mark Moss, MD

      Affiliations

    • Clinical Science Center, University of Wisconsin, and the Department of Pediatrics, University of California-San Diego, San Diego, Calif
    • ,
  • David T. Mauger, PhD

      Affiliations

    • Department of Public Health Sciences, Pennsylvania State University, Hershey, Pa
    • ,
  • Susan J. Boehmer, PhD

      Affiliations

    • Department of Public Health Sciences, Pennsylvania State University, Hershey, Pa
    • ,
  • Robert C. Strunk, MD

      Affiliations

    • Department of Pediatrics, Washington University, St Louis, Mo
    • ,
  • Fernando D. Martinez, MD

      Affiliations

    • Arizona Respiratory Center, University of Arizona, Tucson, Ariz
    • ,
  • Lynn M. Taussig, MD

      Affiliations

    • Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colo
    • ,
  • Childhood Asthma Research and Education Network

Received 19 April 2008 ,Revised 22 August 2008 ,Accepted 25 August 2008.

References 

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  2. CAMP . Long-term effects of budesonide or nedocromil in children with asthma. Childhood Asthma Management Program Research Group. N Engl J Med. 2000;343:1054–1063
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  4. Sorkness CA, Lemanske RF, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD, et al. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2007;119:64–72
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  10. National Asthma Education and Prevention Program: Expert Panel Report 3 (EPR 3): guidelines for the diagnosis and management of asthma—summary report 2007. J Allergy Clin Immunol. 2007;120(suppl):S94–S138
  11. Gergen PJ, Mitchell H, Lynn H. Understanding the seasonal pattern of childhood asthma: results from the National Cooperative Inner-City Asthma Study (NCICAS). J Pediatr. 2002;141:631–636
  12. Reeves MJ, Lyon-Callo S, Brown MD, Rosenman K, Wasilevich E, Williams SG. Using billing data to describe patterns in asthma-related emergency department visits in children. Pediatrics. 2006;117:S106–S117
  13. Silverman RA, Stevenson L, Hastings HM. Age-related seasonal patterns of emergency department visits for acute asthma in an urban environment. Ann Emerg Med. 2003;42:577–586
  14. Silverman RA, Ito K, Stevenson L, Hastings HM. The relationship of fall school opening and emergency department asthma visits in a large metropolitan area. Arch Pediatr Adolesc Med. 2005;159:818–823
  15. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61:376–382
  16. Tattersfield AE, Postma DS, Barnes PJ, Svensson K, Bauer CA, O'Byrne PM, et al. Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. Am J Respir Crit Care Med. 1999;160:594–599
  17. Brouwer AF, Roorda RJ, Brand PL. Home spirometry and asthma severity in children. Eur Respir J. 2006;28:1131–1137
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  19. Pijnenburg MW, Floor SE, Hop WC, De Jongste JC. Daily ambulatory exhaled nitric oxide measurements in asthma. Pediatr Allergy Immunol. 2006;17:189–193
  20. Gelb AF, Flynn Taylor C, Shinar CM, Gutierrez C, Zamel N. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest. 2006;129:1492–1499

 Supported by grants 5U10HL064287, 5U10HL064288, 5U10HL064295, 5U10HL064307, 5U10HL064305, and 5U10HL064313 from the National Heart, Lung, and Blood Institute; General Clinical Research Centers at Washington University School of Medicine (M01 RR00036); and National Jewish Medical and Research Center (M01 RR00051).

 Disclosure of potential conflict of interest: R. A. Covar has received honoraria from Aerocrine NIOX and has received research support as a coinvestigator from Abbott Laboratories. S. J. Szefler has served as a consultant for AstraZeneca, GlaxoSmithKline, Aventis, Genentech, and Merck and has received research grants from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) Childhood Asthma Management Program, NHLBI Childhood Asthma Research and Education, the NIH/NHLBI Asthma Clin Res Network, the NIH/National Institute of Allergy and Infectious Diseases Inner-City Asthma Consortium, and Ross Pharmaceuticals. R. S. Zeiger has served as a consultant for Aerocrine, AstraZeneca, Dynavax, Genentech, Merck, Novartis, and GlaxoSmithKline and has received research support from Sanofi-Aventis, Teva-Pharmaceuticals, Merck, AstraZeneca, GlaxoSmithKline, and Genentech. C. A. Sorkness has served on the speakers' bureau for GlaxoSmithKline and has received research support from GlaxoSmithKline and Pharmaxis. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01552-2

doi: 10.1016/j.jaci.2008.08.021

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 741-747.e4 , October 2008

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