Administration of oral vitamin D induces cathelicidin production in atopic individuals

Increase in cathelicidin expression in lesional atopic skin. Cathelicidin mRNA measured by qRT-PCR in lesional and nonlesional skin of atopic subjects and nonlesional skin of normal subjects. Atopic involved skin showed significantly higher hCAP18 mRNA expression with vitamin D supplementation compared with normal skin and AD nonlesional skin (P < .01 by 1-way ANOVA). Data are shown as relative expression as normalized by the median of pretreatment controls (bars, median of each group).