The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 685-688 , October 2008

Etiology of asthma exacerbations

  • Annemarie Sykes, MBBS, MSc

      Affiliations

    • Corresponding Author InformationReprint requests: Annemarie Sykes, MBBS, MSc, Department of Respiratory Medicine, National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W21PG, United Kingdom.
    • ,
  • Sebastian L. Johnston, MBBS, PhD

Received 24 July 2008 ,Revised 6 August 2008 ,Accepted 7 August 2008.

References 

  1. Chauhan AJ, Inskip HM, Linaker CH, Smith S, Schreiber J, Johnston SL, et al. Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children. Lancet. 2003;361:1939–1944
  2. Peden DB. The epidemiology and genetics of asthma risk associated with air pollution. J Allergy Clin Immunol. 2005;115:213–219
  3. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995;310:1225–1229
  4. Wark PAB, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J. 2001;19:68–75
  5. Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, et al. Frequency, severity and duration of rhinovirus infections in asthmatic and non-asthmatics individuals: a longitudinal cohort study. Lancet. 2002;359:831–834
  6. Message SD, Laza-Stanca V, Mallia P, Parker HL, Zhu J, Contoli M, et al. Rhinovirus induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A 2008. In press.
  7. Wark PAB, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005;201:937–947
  8. Gehlhar K, Bilitewski C, Reinitz-Rademacher K, Rohde G, Bufe A. Impaired virus-induced interferon-alpha2 release in adult asthmatic patients. Clin Exp Allergy. 2006;36:331–337
  9. Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PAB, Bartlett NW, et al. Role of deficient type III interferon-λ production in asthma exacerbations. Nat Med. 2006;12:1023–1026
  10. Papadopoulos NG, Papi A, Psarras S, Johnston SL. Mechanisms of rhinovirus-induced asthma. Paediatr Respir Rev. 2004;5:255–260
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  13. Wark P, Bucchieri F, Johnston SL, Gibson P, Hamilton L, Mimica J, et al. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol. 2007;120:586–593
  14. Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med. 2008;14:199–204
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  27. O'Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O'Connell EJ, Ballard DJ, et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med. 1991;324:359–363
  28. Murray CS, Simpson A, Custovic A. Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc. 2004;1:99–104
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  30. Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ. 2002;324:763
  31. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61:376–382

 Disclosure of potential conflict of interest: A. Sykes has received research support from AstraZeneca. S. L. Johnston has received research support from or consulted for Synairgen, Centocor, AstraZeneca, GlaxoSmithKline, Pfizer, and Sanofi Pasteur.

PII: S0091-6749(08)01513-3

doi: 10.1016/j.jaci.2008.08.017

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 685-688 , October 2008

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