The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 820-827.e9 , October 2008

Differences in allergic sensitization by self-reported race and genetic ancestry

  • James J. Yang, PhD

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • ,
  • Esteban G. Burchard, MD, MPH

      Affiliations

    • Department of Medicine, University of California San Francisco, San Francisco, Calif
    • Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, Calif
    • ,
  • Shweta Choudhry, PhD

      Affiliations

    • Department of Medicine, University of California San Francisco, San Francisco, Calif
    • ,
  • Christine C. Johnson, PhD, MPH

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • ,
  • Dennis R. Ownby, MD

      Affiliations

    • Department of Pediatrics, Medical College of Georgia, Augusta, Ga
    • ,
  • David Favro, BA

      Affiliations

    • Center for Health Services Research, Henry Ford Health System, Detroit, Mich
    • ,
  • Justin Chen, BS

      Affiliations

    • Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif
    • ,
  • Matthew Akana, BA

      Affiliations

    • Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif
    • ,
  • Connie Ha, BS

      Affiliations

    • Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif
    • ,
  • Pui-Yan Kwok, MD, PhD

      Affiliations

    • Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif
    • ,
  • Richard Krajenta, BS

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • ,
  • Suzanne L. Havstad, MS

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • ,
  • Christine L. Joseph, PhD

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • ,
  • Max A. Seibold, BA

      Affiliations

    • Department of Medicine, University of California San Francisco, San Francisco, Calif
    • Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, Calif
    • ,
  • Mark D. Shriver, PhD

      Affiliations

    • Department of Anthropology, Pennsylvania State University, University Park, Pa
    • ,
  • L. Keoki Williams, MD, MPH

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich
    • Center for Health Services Research, Henry Ford Health System, Detroit, Mich
    • Department of Medicine, Henry Ford Health System, Detroit, Mich
    • Corresponding Author InformationReprint requests: L. Keoki Williams, MD, MPH, Center for Health Services Research, Henry Ford Health System, 1 Ford Place, 3A CHSR, Detroit, MI 48202.

Received 20 May 2008 ,Revised 29 July 2008 ,Accepted 30 July 2008.

  • Image Result

    Individual admixture estimates for the 385 participants who reported being African American (A) and for the 216 participants who reported being white (B). Each patient number (column) comprises an ind

    Individual admixture estimates for the 385 participants who reported being African American (A) and for the 216 participants who reported being white (B). Each patient number (column) comprises an individual and their admixture, where gray represents African ancestry and blue represents European ancestry.

  • Image Result
    Distribution of study participants within the city limits of Detroit (also includes Hamtramck and Highland Park shown with bolded outlines). Participants who reported being African American are shown

    Distribution of study participants within the city limits of Detroit (also includes Hamtramck and Highland Park shown with bolded outlines). Participants who reported being African American are shown against the proportion of individuals within each census tract who reported being African American (A), and participants who reported being white are shown against the proportion of individuals within each census tract who reported being white (B). Census tract proportions are taken from year 2000 US Census data.

 Supported by grants from the Fund for Henry Ford Hospital, the Sandler Program for Asthma Research, and the National Institute of Allergy and Infectious Diseases (AI61774, AI50681, and AI59415) and the National Heart, Lung, and Blood Institute (HL79055), National Institutes of Health.

 Disclosure of potential conflict of interest: E. G. Burchard has received research support from the National Institutes of Health (NIH) and the Flight Attendants Medical Research Institute and has served as a member of the American Thoracic Society (ATS). S. Choudhry has received research support from the ATS and the TRDRP. C. C. Johnson has received research support from the NIH and Henry Ford Hospital. D. R. Ownby has received research support from the National Institute of Allergy and Infections Diseases (NIAID), the American Academy of Pediatrics, and the Merck Childhood Asthma Network. P.-Y. Kwok has received research support from the NIH and has consulted on DNA analysis technology patent litigation. C. L. Joseph has received research support from the NIH. M. D. Shriver has consulting arrangements with DNAPrint Genomics and has received research support from the National Human Genome Research Institute, the NIH, the National Institute of Child Health and Human Development, the March of Dimes, and the National heart, Lung, and Blood Institute (NHLBI). L. K. Williams has received research support from the NIAID, the NIH, the NHLBI, and the Strategic Program for Asthma Research. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01457-7

doi: 10.1016/j.jaci.2008.07.044

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 820-827.e9 , October 2008

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