The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 734-740 , October 2008

Steroids completely reverse albuterol-induced β2-adrenergic receptor tolerance in human small airways

  • Philip R. Cooper, PhD
    • ,
  • Reynold A. Panettieri Jr., MD

      Affiliations

    • Corresponding Author InformationReprint requests: Reynold A. Panettieri, Jr, MD, Airways Biology Initiative TRL, Suite 1200, 125 South 31st St, Philadelphia, PA 19104.

Received 17 March 2008 ,Revised 28 July 2008 ,Accepted 30 July 2008.

References 

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  14. Mak JC, Nishikawa M, Barnes PJ. Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung. Am J Physiol Lung Cell Mol Physiol. 1995;268:L41–L46
  15. Kaur M, Chivers JE, Giembycz MA, Newton R. Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol. 2008;73:203–214
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 Supported by HL080676, HL064063, HL081824, and ES013508.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01375-4

doi: 10.1016/j.jaci.2008.07.040

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 734-740 , October 2008

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