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Volume 122, Issue 4 , Pages 760-765 , October 2008

Expired nitric oxide and airway reactivity in infants at risk for asthma

Robert S. Tepper, MD, PhD
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind
- Reprint requests: Robert S. Tepper, MD, PhD, Department of Pediatrics Indiana University Medical Center, James Whitcomb Riley Hospital for Children, 702 Barnhill Dr, ROC 4270, Indianapolis, IN 46202-5225.
Conrado J. Llapur, MD
- Department of Pediatrics, Hospital del Niño Jesús, Cátedra de Metodología de la Investigación, Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina
Marcus H. Jones, MD, PhD
- Department of Pediatrics, Pontifícia Universidade Católica do Rio Grande do Sul, Porte Alegre, Brazil
Christina Tiller, RRT
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind
Cathy Coates, RN
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind
Risa Kimmel, RN
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind
Jeffrey Kisling, RRT
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind
Barry Katz, PhD
- Department of Biostatistics, Indiana University Medical Center, Indianapolis, Ind
Yan Ding, MS
- Department of Biostatistics, Indiana University Medical Center, Indianapolis, Ind
Nancy Swigonski, MD, MPH
- Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Wells Center for Pediatric Research, Indianapolis, Ind

Received 12 March 2008 ,Revised 24 July 2008 ,Accepted 25 July 2008.

Comparison of infants sensitized to either egg or milk and those infants not sensitized to either egg or milk. Box plots illustrate distribution of data. A, Mean ± SE forced expiratory flows (FEF₇₅) w

Comparison of infants sensitized to either egg or milk and those infants not sensitized to either egg or milk. Box plots illustrate distribution of data. A, Mean ± SE forced expiratory flows (FEF₇₅) were significantly less in the infants sensitized to egg or milk (336 ± 12 vs 280 ± 16 mL/s, P < .003). B, Mean ± SE PC₃₀ values were significantly less in infants sensitized to egg or milk (−0.6 ± 0.2 vs −1.2 ± 0.2 mg/mL, P < .023). C, Mean ± SE eNO levels were not significantly different for the 2 groups (11.6 ± 1.0 vs 13.8 ± 1.3 ppb, P = .15).
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Box plots illustrate distribution of eNO. Mean ± SE values were significantly greater (11.2 ± 1.0 vs 14.6 ± 1.3 ppb, P < .023) for infants with IgE levels of 20 IU/mL or greater versus those with IgE

Box plots illustrate distribution of eNO. Mean ± SE values were significantly greater (11.2 ± 1.0 vs 14.6 ± 1.3 ppb, P < .023) for infants with IgE levels of 20 IU/mL or greater versus those with IgE levels of less than 20 IU/mL.
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Increasing eNO levels (in parts per billion) correlated with lower PC30 values (in milligrams per milliliter) or heightened airway reactivity (r = −0.26, P = .02).

Increasing eNO levels (in parts per billion) correlated with lower PC₃₀ values (in milligrams per milliliter) or heightened airway reactivity (r = −0.26, P = .02).
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