New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007

This review summarizes selected articles appearing from January to December 2007 in the Journal of Allergy and Clinical Immunology. Articles were chosen that related to advances in mechanisms of chronic allergic inflammation and asthma, including those describing gene association studies, mast cells, IgE, eosinophils, cytokines, the inception of allergy, airway remodeling, preclinical therapeutic targets, and virally induced asthma.

Abbreviations used: ADAM, A disintegrin and metalloproteinase, CC10, Clara cell protein 10, COPD, Chronic obstructive pulmonary disease, CysLT, Cysteinyl leukotriene, EE, Eosinophilic esophagitis, GILZ, Glucocorticoid-induced leucine zipper, IL-13Rα2, IL-13 receptor α2, IP-10, IFN-γ–induced protein 10, LT, Leukotriene, RSV, Respiratory syncytial virus, SNP, Single nucleotide polymorphism