The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 768-773.e1 , October 2008

Increase in inflammatory mediator concentrations in exhaled breath condensate after allergen inhalation

  • Emiko Ono, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
    • Corresponding Author InformationReprint requests: Emiko Ono, MD, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sakuradai 18-1, Sagamihara, Kanagawa 228-8522, Japan.
  • ,
  • Haruhisa Mita, PhD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
  • ,
  • Masami Taniguchi, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
  • ,
  • Noritaka Higashi, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
  • ,
  • Takahiro Tsuburai, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
  • ,
  • Maki Hasegawa, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
  • ,
  • Eishi Miyazaki, MD

      Affiliations

    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
  • ,
  • Toshihide Kumamoto, MD

      Affiliations

    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
  • ,
  • Kazuo Akiyama, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

Received 21 February 2008 ,Revised 2 June 2008 ,Accepted 6 June 2008.

References 

  1. Bhat KN, Arroyave CM, Marney SR, Stevenson DD, Tan EM. Plasma histamine changes during provoked bronchospasm in asthmatic patients. J Allergy Clin Immunol. 1976;58:647–656
  2. Becky Kelly EA, Busse WW, Jarjour NN. A comparison of the airway response to segmental antigen bronchoprovocation in atopic asthma and allergic rhinitis. J Allergy Clin Immunol. 2003;111:79–86
  3. Naclerio RM, Proud D, Togias AG, Adkinson NF, Meyers DA, Kagey-Sobotka A, et al. Inflammatory mediators in late antigen-induced rhinitis. N Engl J Med. 1985;313:65–70
  4. Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, et al. Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med. 2000;162:878–882
  5. Kumlin M, Dahlén B, Björck T, Zetterström O, Granström E, Dahlén S-E. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis. 1992;146:96–103
  6. Gleich GL, Hull WM. Measurement of histamine: a quality control study. J Allergy Clin Immunol. 1989;66:295–298
  7. Schwartz LB, Yunginger JW, Miller J, Bokhari R, Dull D. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest. 1989;83:1551–1555
  8. National Asthma Education and Prevention Program. Expert panel report 2: guidelines for the diagnosis and management of asthma. Bethesda (MD): National Heart, Lung, and Blood Institute; 1997;NIH publication no. 97-4051
  9. Chai H. Antigen and methacholine challenge in children with asthma. J Allergy Clin Immunol. 1979;64:575–579
  10. Horvath I, Hunt J, Barnes PJ. On behalf of the ATS/ERS Task Force on Exhaled Breath Condensate. ATS/ERS Task Force Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005;26:523–548
  11. Mita H, Higashi N, Taniguchi M, Higashi A, Kawagishi Y, Akiyama K. Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: Lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after aspirin challenge. Clin Exp Allergy. 2004;34:931–938
  12. Mita H, Oosaki R, Mizushima Y, Kobayashi M, Akiyama K. Efficient method for the quantitation of urinary leukotriene E4: extraction using an Empore C18 disk cartridge. J Chromatgr B Biomed Sci Appl. 1997;692:461–466
  13. O'Sullivan S, Dahlen B, Dahlen SE, Kumlin M. Increased urinary excretion of the prostaglandin D2 metabolite 9α, 11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. J Allergy Clin Immunol. 1996;98:421–432
  14. Recommendations for standardized procedures for the on-line and off-line oxide in adults and children—1999: official statement of the American Thoracic Society 1999. Am J Respir Crit Care Med. 1999;160:2104–2117
  15. Debley JS, Hallstrand TS, Monge T, Ohanian A, Redding GJ, Zimmerman J. Methods to improve measurement of cysteinyl leukotrienes in exhaled breath condensate from subjects with asthma and healthy controls. J Allergy Clin Immunol. 2007;120:1216–1217
  16. Bayley DL, Abusriwl H, Ahmad A, Stockley RA. Validation of assays for inflammatory mediators in exhaled breath condensate. Eur Respir J. 2008;31:943–948
  17. Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, Holgate ST, et al. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotriene B4 and C4. Clin Exp Allergy. 2007;37:880–892
  18. Dworski R, Sheller JR. Urinary mediators and asthma. Clin Exp Allergy. 1998;28:1309–1312
  19. Tanaka K, Ogawa K, Sugamura K, Nakamura M, Takano S, Nagata K. Differential production of prostaglandin D2 by human helper T cell subsets. J Immunol. 2000;164:2277–2280
  20. Pierzchalska M, Szabó Z, Sanak M, Soja J, Szczeklik A. Deficient prostaglandin E2 production by bronchial fibroblasts in asthmatics patients, with special reference to aspirin-induced asthma. J Allergy Clin Immunol. 2003;111:1041–1048
  21. Maciejewski-Lenoir D, Richman JG, Hakak Y, Gaidarov I, Behan DP, Connolly DT. Langerhans cells release prostaglandin D2 in response to nicotinic acid. J Invest Dermatol. 2006;126:2637–2646
  22. Fick RB, Richerson HB, Zavala DC, Hunninghake GW. Bronchoalveolar lavage in allergic asthmatics. Am Rev Respir Dis. 1987;135:1204–1209
  23. Sekizawa K, Nakazawa H, Morikawa M, Yamauchi K, Maeyama K, Watanabe T, et al. Histamine N-methyltransferase inhibitor potentiates histamine- and antigen-induced airway microvascular leakage in guinea pigs. J Allergy Clin Immunol. 1995;96:910–916
  24. Lindstöm EG, Andersson RG, Granérus G, Grundström N. Is the airway epithelium responsible for histamine metabolism in the trachea of guinea pigs?. Agents Actions. 1991;33:170–172
  25. Maltby NH, Taylor GW, Ritter JM, Moore K, Fuller RW, Dollery CT. Leukotriene C4 elimination and metabolism in man. J Allergy Clin Immunol. 1990;85:3–9

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01130-5

doi: 10.1016/j.jaci.2008.06.009

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 768-773.e1 , October 2008