The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 768-773.e1 , October 2008

Increase in inflammatory mediator concentrations in exhaled breath condensate after allergen inhalation

  • Emiko Ono, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
    • Corresponding Author InformationReprint requests: Emiko Ono, MD, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sakuradai 18-1, Sagamihara, Kanagawa 228-8522, Japan.
    • ,
  • Haruhisa Mita, PhD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • ,
  • Masami Taniguchi, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • ,
  • Noritaka Higashi, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • ,
  • Takahiro Tsuburai, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • ,
  • Maki Hasegawa, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    • ,
  • Eishi Miyazaki, MD

      Affiliations

    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
    • ,
  • Toshihide Kumamoto, MD

      Affiliations

    • Division of the Third Department of Internal Medicine, Oita University School of Medicine, Yuhu, Oita, Japan
    • ,
  • Kazuo Akiyama, MD

      Affiliations

    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

Received 21 February 2008 ,Revised 2 June 2008 ,Accepted 6 June 2008.

  • Image Result

    Changes in CysLT concentrations in EBC (A), LTE4 concentrations in urine (B), PGD2 concentrations in EBC (C), and 9α, 11β-PGF2 concentrations in urine (D) before and after allergen inhalation.

    Changes in CysLT concentrations in EBC (A), LTE4 concentrations in urine (B), PGD2 concentrations in EBC (C), and 9α, 11β-PGF2 concentrations in urine (D) before and after allergen inhalation.

  • Image Result

    Correlation between increase in concentration of CysLT (abscissa) and that of PGD2 (ordinate) in EBC samples from patients with EARs after allergen inhalation.

    Correlation between increase in concentration of CysLT (abscissa) and that of PGD2 (ordinate) in EBC samples from patients with EARs after allergen inhalation.

  • Image Result

    In the patients with allergen-induced EARs, the decreased percentage in FEV1 significantly correlated with the increase in CysLT concentration in EBC (A) but not with the increase in urinary LTE4 conc

    In the patients with allergen-induced EARs, the decreased percentage in FEV1 significantly correlated with the increase in CysLT concentration in EBC (A) but not with the increase in urinary LTE4 concentration (B) after allergen inhalation.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(08)01130-5

doi: 10.1016/j.jaci.2008.06.009

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 4 , Pages 768-773.e1 , October 2008

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