The Journal of Allergy and Clinical Immunology
Volume 122, Issue 2 , Pages 280-285 , August 2008

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

  • John A. Burgess, MBBS, FRACP, MEpid

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
    • Corresponding Author InformationReprint requests: John A. Burgess, MBBS, FRACP, MEpid, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Level 1, 723 Swanston Street, Carlton, Victoria 3053 Australia.
  • ,
  • Shyamali C. Dharmage, MBBS, MD, MSc, PhD

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • Graham B. Byrnes, BSc (Hons), PhD

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • Melanie C. Matheson, BSc, MAppSc, PhD

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • Lyle C. Gurrin, BSc (Hons), PhD, AStat

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • Cathryn L. Wharton, BAppSc, GradCertHlthInfo

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • David P. Johns, CRFS, PhD, FANZSRS

      Affiliations

    • Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Australia
  • ,
  • Michael J. Abramson, MBBS, BMedSc (Hons), FRACP, PhD, FAFPHM

      Affiliations

    • Department of Epidemiology and Preventive Medicine, Monash University, The Alfred, Melbourne, Australia
  • ,
  • John L. Hopper, BSc, MSc, PhD, BA

      Affiliations

    • Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
  • ,
  • E. Haydn Walters, MA, DM, FRCP, FRACP

      Affiliations

    • Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Australia

Received 19 September 2007 ,Revised 1 May 2008 ,Accepted 5 May 2008.

References 

  1. Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB, Manuel JC. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005;22:192–199
  2. Lapidus CS, Kerr PE. Social impact of atopic dermatitis. Med Health R I. 2001;84:294–295
  3. Su JC, Kemp AS, Varigos GA, Nolan TM. Atopic eczema: its impact on the family and financial cost. Arch Dis Child. 1997;76:159–162
  4. Robertson CF, Dalton MF, Peat JK, Haby MM, Bauman A, Kennedy JD, et al. Asthma and other atopic diseases in Australian children. Australian arm of the International Study of Asthma and Allergy in Childhood. Med J Aust. 1998;168:434–438
  5. O'Connell EJ. The burden of atopy and asthma in children. Allergy. 2004;59(suppl 78):7–11
  6. Broberg A, Svensson A, Borres MP, Berg R. Atopic dermatitis in 5-6-year-old Swedish children: cumulative incidence, point prevalence, and severity scoring. Allergy. 2000;55:1025–1029
  7. Asher MI, Barry D, Clayton T, Crane J, D'Souza W, Ellwood P, et al. The burden of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema in children and adolescents in six New Zealand centres: ISAAC Phase One. N Z Med J. 2001;114:114–120
  8. Kemp AS. Atopic eczema: its social and financial costs. J Paediatr Child Health. 1999;35:229–231
  9. Stipic-Markovic A, Pevec B, Pevec MR, Custovic A. Prevalence of symptoms of asthma, allergic rhinitis, conjunctivitis and atopic eczema: ISAAC (International Study of Asthma and Allergies in Childhood) in a population of schoolchildren in Zagreb. Acta Med Croatica. 2003;57:281–285
  10. Hanifin JM, Reed ML. A population-based survey of eczema prevalence in the United States. Dermatitis. 2007;18:82–91
  11. Laughter D, Istvan JA, Tofte SJ, Hanifin JM. The prevalence of atopic dermatitis in oregon schoolchildren. J Am Acad Dermatol. 2000;43:649–655
  12. Schultz Larsen F, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1992;176:7–12
  13. Sugiura H, Umemoto N, Deguchi H, Murata Y, Tanaka K, Sawai T, et al. Prevalence of childhood and adolescent atopic dermatitis in a Japanese population: comparison with the disease frequency examined 20 years ago. Acta Derm Venereol. 1998;78:293–294
  14. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet. 1998;351:1225–1232
  15. Bergmann RL, Edenharter G, Bergmann KE, Forster J, Bauer CP, Wahn V, et al. Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy. 1998;28:965–970
  16. Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis: a prospective follow-up to 7 years of age. Allergy. 2000;55:240–245
  17. Ohshima Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T, et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4-year followup study. Ann Allergy Asthma Immunol. 2002;89:265–270
  18. van der Hulst AE, Klip H, Brand PL. Risk of developing asthma in young children with atopic eczema: a systematic review. J Allergy Clin Immunol. 2007;120:565–569
  19. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 2003;112(suppl 6):S118–S127
  20. Simpson EL, Hanifin JM. Atopic dermatitis. J Am Acad Dermatol. 2005;53:115–128
  21. Food allergy, atopic dermatitis and the allergy march: proceedings of a symposium in honour of Professor Luisa Businco, Venice, Italy, November 17-19, 2000. Pediatr Allergy Immunol 2001;12(suppl 14):5-107.
  22. Spergel JM, Mizoguchi E, Brewer JP, Martin TR, Bhan AK, Geha RS. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998;101:1614–1622
  23. Illi S, Von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113:925–931
  24. Rhodes HL, Thomas P, Sporik R, Holgate ST, Cogswell JJ. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. Am J Respir Crit Care Med. 2002;165:176–180
  25. Wahn U, Von Mutius E. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol. 2001;107:567–574
  26. Zapletal A, Paul T, Samanek M. [Significance of contemporary methods of lung function testing for the detection of airway obstruction in children and adolescents] (author's transl). Z Erkr Atmungsorgane. 1977;149:343–371
  27. Wharton C, Dharmage S, Jenkins M, Dite G, Hopper J, Giles G, et al. Tracing 8,600 participants 36 years after recruitment at age seven for the Tasmanian Asthma Study. Aust N Z J Public Health. 2006;30:105–110
  28. Burgess JA, Walters EH, Byrnes GB, Wharton C, Jenkins MA, Abramson MJ, et al. Who remembers whether they had asthma as children?. J Asthma. 2006;43:727–730
  29. Hancox RJ, Whyte K. Pocket guide to lung function tests. Roseville, Australia: McGraw-Hill Australia; 2001;p. xvi
  30. Australian Bureau of Statistics. Australian Standard Classification of Occupations. 2nd ed. Cat. no. 1220.0 Canberra: Australian Bureau of Statistics; 1997.
  31. Hosmer D, Lemeshow S. Applied logistic regression. 2nd ed.. New York: John Wiley & Sons, Inc; 2000;
  32. Williams HC, Burney PG, Hay RJ, Archer CB, Shipley MJ, Hunter JJ, et al. The UK Working Party's Diagnostic Criteria for Atopic Dermatitis, I: derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131:383–396
  33. Ricci G, Patrizi A, Baldi E, Menna G, Tabanelli M, Masi M. Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases. J Am Acad Dermatol. 2006;55:765–771
  34. Hill AB. The environment and disease: association or causation?. Proc R Soc Med. 1965;58:295–300
  35. Beyer K, Nickel R, Freidhoff L, Bjorksten B, Huang SK, Barnes KC, et al. Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. J Invest Dermatol. 2000;115:906–908
  36. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, et al. Genetic susceptibility to asthma: bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995;333:894–900
  37. Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med. 2003;348:977–985
  38. Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med. 2005;171:137–141
  39. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354:541–545
  40. Burgess JA, Walters EH, Byrnes GB, Matheson MC, Jenkins MA, Wharton CL, et al. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. J Allergy Clin Immunol. 2007;120:863–869
  41. Toelle BG, Xuan W, Peat JK, Marks GB. Childhood factors that predict asthma in young adulthood. Eur Respir J. 2004;23:66–70
  42. Jenkins MA, Clarke JR, Carlin JB, Robertson CF, Hopper JL, Dalton MF, et al. Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma. Int J Epidemiol. 1996;25:609–616
  43. Remes ST, Pekkanen J, Remes K, Salonen RO, Korppi M. In search of childhood asthma: questionnaire, tests of bronchial hyperresponsiveness, and clinical evaluation. Thorax. 2002;57:120–126
  44. Camargo CA, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 1999;159:2582–2588
  45. Panhuysen CI, Bleecker ER, Koeter GH, Meyers DA, Postma DS. Characterization of obstructive airway disease in family members of probands with asthma: an algorithm for the diagnosis of asthma. Am J Respir Crit Care Med. 1998;157:1734–1742
  46. Silver EJ, Crain EF, Weiss KB. Burden of wheezing illness among U.S. children reported by parents not to have asthma. J Asthma. 1998;35:437–443

 The Tasmanian Longitudinal Health Study is supported by grants from the National Health and Medical Research Council of Australia, the Victorian and Tasmanian Asthma Foundations, the Clifford Craig Medical Research Trust, and the Royal Hobart Hospital Research Foundation. J.A.B. is supported by a Research Scholarship from the University of Melbourne. G.B.B., M.C.M., J.L.H., and S.C.D. are supported by the National Health and Medical Research Council of Australia.

 Disclosure of potential conflict of interest: S. C. Dharmage has received research support from the National Health Medical Research Council, the Asthma Foundation, and the Ilhan Allergy Foundation. M. J. Abramson has served as a member of the Australian Lung Foundation. E. H. Walters has received research support from the National Health Medical Research Council, GlaxoSmithKline, and the Royal Hobart Research Foundation. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00954-8

doi: 10.1016/j.jaci.2008.05.018

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 2 , Pages 280-285 , August 2008