The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 159-165 , July 2008

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study

  • Samuel B. Foster, MD

      Affiliations

    • Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex
    • ,
  • Kenneth McIntosh, MD

      Affiliations

    • Division of Infectious Diseases, Children's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Bruce Thompson, PhD

      Affiliations

    • Clinical Trials & Surveys Corporation, Baltimore, Md
    • ,
  • Ming Lu, MS

      Affiliations

    • Clinical Trials & Surveys Corporation, Baltimore, Md
    • ,
  • Wanrong Yin, MS

      Affiliations

    • Clinical Trials & Surveys Corporation, Baltimore, Md
    • ,
  • Kenneth C. Rich, MD

      Affiliations

    • Department of Pediatrics, University of Illinois at Chicago, Chicago, Ill
    • ,
  • Hermann Mendez, MD

      Affiliations

    • Department of Pediatrics, State University of New York, Brooklyn, NY
    • ,
  • Leslie K. Serchuck, MD

      Affiliations

    • Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Md
    • ,
  • Clemente Diaz, MD

      Affiliations

    • Department of Pediatrics, Puerto Rico School of Medicine, San Juan, Puerto Rico
    • ,
  • Mary E. Paul, MD

      Affiliations

    • Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex
    • ,
  • William T. Shearer, MD, PhD

      Affiliations

    • Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex
    • Corresponding Author InformationReprint requests: William T. Shearer, MD, PhD, Texas Children's Hospital, 6621 Fannin St (MC: FC330.01), Houston, TX 77030.

Received 25 February 2008 ,Revised 4 April 2008 ,Accepted 18 April 2008.

  • Image Result

    Survival analysis results for the time to first asthma medication use. Cox model estimates relating differences between children according to HIV infection status and HAART use (in the HIV+ group) and

    Survival analysis results for the time to first asthma medication use. Cox model estimates relating differences between children according to HIV infection status and HAART use (in the HIV+ group) and respective P values are annotated in the lower right-hand portion of the graph. Estimated cumulative incidences for each group at 2, 5, 10, and 13.5 years of age are annotated in the upper left-hand portion of the graph.

  • Image Result
    Prevalence of asthma medication use for children born in the pre-HAART era using GEEs. Data are presented by using a 3-point moving average. No asthma medications were used by any group before 60 mont

    Prevalence of asthma medication use for children born in the pre-HAART era using GEEs. Data are presented by using a 3-point moving average. No asthma medications were used by any group before 60 months.

  • Image Result
    Median CD4+ T-cell percentages in children aged 6 to 10 years indexed according to the time of first asthma medication use (Time 0). The slope estimates of CD4+ T cell percentages from the mixed-model

    Median CD4+ T-cell percentages in children aged 6 to 10 years indexed according to the time of first asthma medication use (Time 0). The slope estimates of CD4+ T cell percentages from the mixed-model analysis are annotated in the upper portion of the graph.

 Supported by National Institutes of Health grants and contracts HL96040, HL079533, HL72705, AI27551, AI36211, HD41983, RR0188, and AI41089; the Pediatric Research and Education Fund, Baylor College of Medicine; the David Fund, Pediatric AIDS Fund, and Immunology Research Fund, Texas Children's Hospital.

 Disclosure of potential conflict of interest: K. McIntosh has served as an expert witness for Pfizer on the treatment of meningitis in Africa. B. Thompson, M. Lu, and W. Yin are employed by Clinical Trials & Surveys Corporation. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00941-X

doi: 10.1016/j.jaci.2008.04.043

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 159-165 , July 2008

Article Tools

* Image Usage & Resolution