The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 133-138 , July 2008

Use of multiple doses of epinephrine in food-induced anaphylaxis in children

Received 4 February 2008 ,Revised 22 April 2008 ,Accepted 25 April 2008.

References 

  1. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium. J Allergy Clin Immunol. 2006;117:391–397
  2. Gupta R, Sheikh A, Strachan DP, Anderson HP. Time trends in allergic disorders in the UK. Thorax. 2007;62:91–96
  3. Polos LM, Waters AM, Correll PK, Loblay RH, Marks GB. Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Asutralia, 1993-1994 to 2004-2005. J Allergy Clin Immunol. 2007;120:878–884
  4. Lieberman P. Biphasic anaphylactic reactions. Ann Allergy Asthma Immunol. 2005;95:217–226
  5. Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327:380–384
  6. Gold MS, Sainsbury R. First aid anaphylaxis management in children who were prescribed an epinephrine autoinjector device (EpiPen). J Allergy Clin Immunol. 2000;106:171–176
  7. Sicherer SH, Simons FE Section on Allergy and Immunology American Academy of Pediatrics. Self-injectable epinephrine for first-aid management of anaphylaxis. Pediatrics. 2007;119:638–646
  8. Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol. 2007;119:1016–1018
  9. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol. 2001;107:191–193
  10. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000;30:1144–1150
  11. Pumphrey RSH. Further fatal allergic reactions to food in the United Kingdom, 1999-2006: letter to the editor. J Allergy Clin Immunol. 2006;119:1018–1019
  12. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2006;117:S470–S475
  13. Simons FER, Chad ZH, Gold M. Anaphylaxis in children: real-time reporting from a national network. Allergy Clin Immunol Int J World Allergy Org. 2004;(suppl):242–244
  14. Oren E, Banerji A, Clark S, Camargo CA. Food-induced anaphylaxis and repeat epinephrine treatments. Ann Allergy Asthma Immunol. 2007;99:429–432
  15. Uguz A, Lack G, Pumphrey R, Ewan P, Warner J, Dick J, et al. Allergic reactions in the community: a questionnaire survey of members of the anaphylaxis campaign. Clin Exp Allergy. 2005;35:746–750
  16. Korenblat P, Lundie MJ, Dankner RE, Day JH. A retrospective study of epinephrine administration for anaphylaxis: how many doses are needed?. Allergy Asthma Proc. 1999;20:383–386
  17. Varghese M, Lieberman P. Factors affecting the use of automatic epinephrine injectors (AEI). J Allergy Clin Immunol. 2006;117:S305
  18. Webb LM, Lieberman P. Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol. 2006;97:39–43
  19. Kelso JM. A second dose of epinephrine for anaphylaxis: how often needed and how to carry. J Allergy Clin Immunol. 2006;117:464–465
  20. Sampson HA. Anaphylaxis and emergency treatment. Pediatrics. 2003;111:1601–1608
  21. Wood RA. The natural history of food allergy. Pediatrics. 2003;111:1631–1637
  22. Kemp AS. EpiPen epidemic: suggestions for rational prescribing in childhood food allergy. J Paediatr Child Health. 2003;39:372–375
  23. Pumphrey R. Anaphylaxis: can we tell who is at risk of a fatal reaction?. Curr Opin Allergy Clin Immunol. 2004;4:285–290
  24. Pumphrey RS. Fatal anaphylaxis in the UK, 1992-2001. Novartis Found Symp. 2004;257:116–128
  25. Simons FE. Apparent lack of response to epinephrine in anaphylaxis. J Allergy Clin Immunol. 2005;115:640

 K. M. Järvinen is supported in part by the 2007 American Academy of Allergy, Asthma & Immunology Third-Year Fellow-in-Training Research Award. S. H. Sicherer and H. A. Sampson are supported in part by grants from the National Institutes of Health, AI44236 and AI066738. A. Nowak-Wegrzyn is supported in part by a grant from the National Institutes of Health, National Institute of Allergy and Infectious Diseases, AI059318.

 Disclosure of potential conflict of interest: K. M. Järvinen has received research support from the American Academy of Allergy, Asthma & Immunology. S. H. Sicherer has consulting arrangements with the Food Allergy Initiative, has received research support from the National Institutes of Health, and has served as a member of the Food Allergy and Anaphylaxis Network and the American Academy of Pediatrics. H. A. Sampson has consulting arrangements with Allertein Therapeutics, has received research support from the National Institutes of Health and the Food Allergy Initiative, and has served as a member of the Food Allergy and Anaphylaxis Network. A. Nowak-Wegrzyn has received research support from the National Institutes of Health.

PII: S0091-6749(08)00775-6

doi: 10.1016/j.jaci.2008.04.031

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 133-138 , July 2008