The Journal of Allergy and Clinical Immunology
Volume 121, Issue 6 , Pages 1442-1447 , June 2008

Preventive effect of hydrolyzed infant formulas persists until age 6 years: Long-term results from the German Infant Nutritional Intervention Study (GINI)

  • Andrea von Berg, MD

      Affiliations

    • Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
    • Corresponding Author InformationReprint requests: Andrea von Berg, MD, Marien-Hospital Wesel, Department of Pediatrics, Pastor-Janssen-Str. 8-38, Wesel, Germany.
    • ,
  • Birgit Filipiak-Pittroff, MSc

      Affiliations

    • Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
    • ,
  • Ursula Krämer, PhD

      Affiliations

    • Institut für Umweltmedizinische Forschung at the Heinrich-Heine-University, Düsseldorf, Germany
    • ,
  • Elke Link

      Affiliations

    • Institut für Umweltmedizinische Forschung at the Heinrich-Heine-University, Düsseldorf, Germany
    • ,
  • Christina Bollrath, MD

      Affiliations

    • Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
    • ,
  • Inken Brockow, MD

      Affiliations

    • Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
    • Department of Pediatrics, Technical University of Munich, Munich, Germany
    • ,
  • Sibylle Koletzko, MD

      Affiliations

    • Ludwig-Maximilians-University, Dr von Haunersches Kinderspital, Munich, Germany
    • ,
  • Armin Grübl, MD

      Affiliations

    • Department of Pediatrics, Technical University of Munich, Munich, Germany
    • ,
  • Joachim Heinrich, PhD

      Affiliations

    • Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
    • ,
  • H.-Erich Wichmann, MD, PhD

      Affiliations

    • Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
    • Institute of Medical Data Management, Biometrics and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Carl-P. Bauer, MD

      Affiliations

    • Department of Pediatrics, Technical University of Munich, Munich, Germany
    • LVA Oberbayern, Munich, Germany
    • ,
  • Dietrich Reinhardt, MD

      Affiliations

    • Ludwig-Maximilians-University, Dr von Haunersches Kinderspital, Munich, Germany
    • ,
  • Dietrich Berdel, MD

      Affiliations

    • Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
    • ,
  • GINIplus study group

Received 20 December 2007 ,Revised 18 April 2008 ,Accepted 21 April 2008.

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 The German Infant Nutritional Intervention study was supported for the first 3 years by grants of the Federal Ministry for Education, Science, Research and Technology (Grant No. 01 EE 9401-4). The 6-year follow-up was partly funded by the Federal Ministry for Environment (IUF, FKZ 20462296) and by the GSF National Research Center for the Environment and Health.

 Disclosure of potential conflict of interest: A. von Berg has served on the speakers' bureau for MSD, Nestlé, Novartis, and Aerocrine; has served as the principal investigator for Nestlé, Mead Johnson, GlaxoSmithKline, Aerocrine, Nycomed, MSD, Allergopharma, and ALK-Abelló; and has served as an expert witness for Aerocrine and Novartis. U. Krämer has received research support from the Deutsche gesetzliche Unfallversicherung and the Federal Ministry for Environment. E. Link has received research support from the Federal Ministry for Environment. S. Koletzko has received honoraria from Nestlé, Nutricia, and Hipp and has served as an investigator for Nestlé. D. Berdel has served on the speakers' bureau for MSD, Nestlé, and Wyeth. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00765-3

doi: 10.1016/j.jaci.2008.04.021

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 6 , Pages 1442-1447 , June 2008

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