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Volume 121, Issue 6 , Pages 1442-1447 , June 2008

Preventive effect of hydrolyzed infant formulas persists until age 6 years: Long-term results from the German Infant Nutritional Intervention Study (GINI)

Andrea von Berg, MD
- Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
- Reprint requests: Andrea von Berg, MD, Marien-Hospital Wesel, Department of Pediatrics, Pastor-Janssen-Str. 8-38, Wesel, Germany.
Birgit Filipiak-Pittroff, MSc
- Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
Ursula Krämer, PhD
- Institut für Umweltmedizinische Forschung at the Heinrich-Heine-University, Düsseldorf, Germany
Elke Link
- Institut für Umweltmedizinische Forschung at the Heinrich-Heine-University, Düsseldorf, Germany
Christina Bollrath, MD
- Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
Inken Brockow, MD
- Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
- Department of Pediatrics, Technical University of Munich, Munich, Germany
Sibylle Koletzko, MD
- Ludwig-Maximilians-University, Dr von Haunersches Kinderspital, Munich, Germany
Armin Grübl, MD
- Department of Pediatrics, Technical University of Munich, Munich, Germany
Joachim Heinrich, PhD
- Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
H.-Erich Wichmann, MD, PhD
- Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany
- Institute of Medical Data Management, Biometrics and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
Carl-P. Bauer, MD
- Department of Pediatrics, Technical University of Munich, Munich, Germany
- LVA Oberbayern, Munich, Germany
Dietrich Reinhardt, MD
- Ludwig-Maximilians-University, Dr von Haunersches Kinderspital, Munich, Germany
Dietrich Berdel, MD
- Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
GINIplus study group

Received 20 December 2007 ,Revised 18 April 2008 ,Accepted 21 April 2008.

GINI study profile from birth to 6 years. Number of followed children in the ITT population (all randomized, shaded boxes) and the PP population (open boxes) in which fully breast-fed (n = 889) and no

GINI study profile from birth to 6 years. Number of followed children in the ITT population (all randomized, shaded boxes) and the PP population (open boxes) in which fully breast-fed (n = 889) and noncompliant (n = 375) children were excluded.
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The German Infant Nutritional Intervention study was supported for the first 3 years by grants of the Federal Ministry for Education, Science, Research and Technology (Grant No. 01 EE 9401-4). The 6-year follow-up was partly funded by the Federal Ministry for Environment (IUF, FKZ 20462296) and by the GSF National Research Center for the Environment and Health.

Disclosure of potential conflict of interest: A. von Berg has served on the speakers' bureau for MSD, Nestlé, Novartis, and Aerocrine; has served as the principal investigator for Nestlé, Mead Johnson, GlaxoSmithKline, Aerocrine, Nycomed, MSD, Allergopharma, and ALK-Abelló; and has served as an expert witness for Aerocrine and Novartis. U. Krämer has received research support from the Deutsche gesetzliche Unfallversicherung and the Federal Ministry for Environment. E. Link has received research support from the Federal Ministry for Environment. S. Koletzko has received honoraria from Nestlé, Nutricia, and Hipp and has served as an investigator for Nestlé. D. Berdel has served on the speakers' bureau for MSD, Nestlé, and Wyeth. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00765-3

doi: 10.1016/j.jaci.2008.04.021

« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 121, Issue 6 , Pages 1442-1447 , June 2008