The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 44-48 , July 2008

Sublingual immunotherapy for large local reactions caused by honeybee sting: A double-blind, placebo-controlled trial

  • Maurizio G. Severino, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Gabriele Cortellini, MD

      Affiliations

    • Internal Medicine and Rheumatology, Rimini Hospital, Rimini, Italy
    • ,
  • Patrizia Bonadonna, MD

      Affiliations

    • Allergy Unit, Verona General Hospital, Verona, Italy
    • ,
  • Elisabetta Francescato, PhD

      Affiliations

    • Entomon SAS, Florence, Italy
    • ,
  • Ilaria Panzini, PhD

      Affiliations

    • Research and Innovation Unit, Rimini Hospital, Rimini, Italy
    • ,
  • Donatella Macchia, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Paolo Campi, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Igino Spadolini, MD

      Affiliations

    • Anallergo, Florence, Italy
    • ,
  • Walter G. Canonica, MD

      Affiliations

    • Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    • ,
  • Giovanni Passalacqua, MD

      Affiliations

    • Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    • Corresponding Author InformationReprint requests: Giovanni Passalacqua, MD, Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, L.go R. Benzi 10, 16132 Genoa, Italy.

Received 7 January 2008 ,Revised 10 March 2008 ,Accepted 31 March 2008.

References 

  1. Bonifazi F, Jutel M, Bilò MB, Birnbaum J, Muller U EAACI Interest Group on insect Venom Hypersensitivity. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice. Allergy. 2005;60:1459–1470
  2. Bilò MB, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink JNG EAACI Interest Group on insect Venom Hypersensitivity. Diagnosis of hymenoptera venom allergy. Allergy. 2005;60:1339–1349
  3. Scadding K, Brostoff J. Low dose sublingual therapy in patients with allergic rhinitis due to dust mite. Clin Allergy. 1986;16:483–491
  4. World Health Organization Position Paper. Allergen immunotherapy: therapeutical vaccines for allergic diseases. Allergy. 1998;53(suppl 52):3–15
  5.  Bousquet J,  Van Cauwenberge PAllergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(suppl):S147–S334
  6. Passalacqua G, Durham SR. ARIA update: allergen specific immunotherapy. J Allergy Clin Immunol. 2007;119:881–891
  7. Wilson DR, Torres L, Durham SR. Sublingual immunotherapy for allergic rhinitis. Allergy. 2005;60:3–8
  8. Penagos M, Compalati E, Tarantini F, Baena Cagnani C, Huerta J, Passalacqua G, et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in children. Meta analysis of randomized controlled trials. Ann Allergy Asthma Immunol. 2006;97:141–148
  9. Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006;117:1021–1035
  10. Moffitt JE, Golden DB, Reisman RE, Lee R, Nicklas R, Freeman T, et al. Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol. 2004;114:869–886
  11. Hamilton RG, Golden DBK, Kagey-Sobotka A, Lichtensten RM. Case report of venom immunotherapy for a patient with large local reactions. Ann Allergy Asthma Immunol. 2001;87:134–137
  12. Kelly D, Golden DBK, Hamilton RG, Craig TJ. Venom immunotherapy reduces large local reactions to insect stings. [abstract] J Allergy Clin Immunol. 2007;119(suppl):S79
  13. Golden DBK, Breisch NL, Hamilton RG, Guralnick MW, Greene A, Craig TJ, et al. Clinical and entomological factors influence the outcome of sting challenge studies. J Allergy Clin Immunol. 2006;117:670–675
  14. Pajno G, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized double blind placebo controlled study. J Allergy Clin Immunol. 2007;120:164–170
  15. Enrique E, Pineda F, Malek T, Bartra J, Basagana M, Tella R, et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol. 2005;116:1073–1079
  16. Nettis E, Colanardi MC, Soccio AL, Marcandrea M, Pinto L, Ferrannini A, et al. Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study. Br J Dermatol. 2007;156:674–681
  17. Mauriello PM, Barde SH, Georgitis JW, Reisman RE. Natural history of large local reactions from stinging insects. J Allergy Clin Immunol. 1984;74:494–498
  18. Dubois A. Investigational and clinical use of the sting challenge. Curr Opin Allergy Clin Immunol. 2003;3:283–285
  19. Green A, Reisman R, Arbesman C. Clinical and immunologic studies of patients with large local reactions following insect stings. J Allergy Clin Immunol. 1980;66:186–189
  20. Golden DBK, Marsh DG, Kagey-Sobotka A, Freidhoff L, Szklo M, Valentine MD, et al. Epidemiology of insect venom sensitivity. JAMA. 1989;262:240–244
  21. Lima MT, Wilson D, Pitkin L, Roberts A, Nouri-Aria K, Jacobson M, et al. Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial. Clin Exp Allergy. 2002;32:507–514
  22. Rolinck-Werninghaus C, Kopp M, Liebke C, Lange J, Wahn U, Niggemann B. Lack of detectable alterations in immune responses during sublingual immunotherapy in children with seasonal allergic rhinoconjunctivitis to grass pollen. Int Arch Allergy Immunol. 2005;136:134–141
  23. Passalacqua G, Albano M, Fregonese L, Riccio A, Pronzato C, Mela S, et al. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Lancet. 1998;351:629–632
  24. Savolainen J, Nieminen K, Laaksonen K, Laiho T, Jacobsen L, Lahesmaa L, et al. Allergen-induced in vitro expression of IL-18, SLAM and GATA-3 mRNA in PBMC during sublingual immunotherapy. Allergy. 2007;62:949–953
  25. Ippoliti F, De Santis W, Volterrani A, Lenti L, Canitano N, Lucarelli S, et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol. 2003;14:216–221
  26. Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C, et al. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol. 2007;120:707–713
  27. Pajno GB, Vita D, Parmiani S, Caminiti L, La Grutta S, Barberio G. Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionate. Clin Exp Allergy. 2003;33:1641–1647
  28. Müller U, Helbling A, Berchtold E. Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety. J Allergy Clin Immunol. 1992;89:529–535

 The sublingual immunotherapy and matched placebo were kindly provided by Anallergo S.p.A, Florence, Italy.

 Disclosure of potential conflict of interest: E. Francescato is employed by Entomon SAS. I. Spadolini owns stock in and is employed by Anallergo. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00617-9

doi: 10.1016/j.jaci.2008.03.031

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 44-48 , July 2008

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