The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 44-48 , July 2008

Sublingual immunotherapy for large local reactions caused by honeybee sting: A double-blind, placebo-controlled trial

  • Maurizio G. Severino, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Gabriele Cortellini, MD

      Affiliations

    • Internal Medicine and Rheumatology, Rimini Hospital, Rimini, Italy
    • ,
  • Patrizia Bonadonna, MD

      Affiliations

    • Allergy Unit, Verona General Hospital, Verona, Italy
    • ,
  • Elisabetta Francescato, PhD

      Affiliations

    • Entomon SAS, Florence, Italy
    • ,
  • Ilaria Panzini, PhD

      Affiliations

    • Research and Innovation Unit, Rimini Hospital, Rimini, Italy
    • ,
  • Donatella Macchia, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Paolo Campi, MD

      Affiliations

    • Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy
    • ,
  • Igino Spadolini, MD

      Affiliations

    • Anallergo, Florence, Italy
    • ,
  • Walter G. Canonica, MD

      Affiliations

    • Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    • ,
  • Giovanni Passalacqua, MD

      Affiliations

    • Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    • Corresponding Author InformationReprint requests: Giovanni Passalacqua, MD, Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, L.go R. Benzi 10, 16132 Genoa, Italy.

Received 7 January 2008 ,Revised 10 March 2008 ,Accepted 31 March 2008.

  • Image Result

    Peak maximal diameter (in centimeters) of the LLR in the SLIT-treated (left) and placebo-treated (right) patients at baseline and after 6 months. Medians are indicated as horizontal thick arrows. Stat

    Peak maximal diameter (in centimeters) of the LLR in the SLIT-treated (left) and placebo-treated (right) patients at baseline and after 6 months. Medians are indicated as horizontal thick arrows. Statistically significant differences are indicated at the top. NS, Not significant.

  • Image Result
    Mean (SEM) honeybee-specific IgE (left) and specific total IgG (right) levels in the active and placebo groups before and after treatment. Values are expressed in kilounits per liter. NS, Not signific

    Mean (SEM) honeybee-specific IgE (left) and specific total IgG (right) levels in the active and placebo groups before and after treatment. Values are expressed in kilounits per liter. NS, Not significant.

 The sublingual immunotherapy and matched placebo were kindly provided by Anallergo S.p.A, Florence, Italy.

 Disclosure of potential conflict of interest: E. Francescato is employed by Entomon SAS. I. Spadolini owns stock in and is employed by Anallergo. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00617-9

doi: 10.1016/j.jaci.2008.03.031

The Journal of Allergy and Clinical Immunology
Volume 122, Issue 1 , Pages 44-48 , July 2008

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