The Journal of Allergy and Clinical Immunology
Volume 121, Issue 5 , Pages 1294-1295 , May 2008

Filaggrin variants confer susceptibility to asthma

  • W. H. Irwin McLean, PhD, DSc

      Affiliations

    • Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Dundee, United Kingdom
    • ,
  • Colin N.A. Palmer, PhD

      Affiliations

    • Population Pharmacogenetics Group, Biomedical Research Center, University of Dundee, Dundee, United Kingdom
    • ,
  • John Henderson, MD

      Affiliations

    • Department of Community-Based Medicine, University of Bristol, Bristol, United Kingdom
    • ,
  • Michael Kabesch, MD

      Affiliations

    • Department of Children's Hospital, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Stephan Weidinger, MD

      Affiliations

    • Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    • Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich-German Research Center for Environmental Health and ZAUM-Center for Allergy and Environment, Technical University Munich, Munich, Germany
    • ,
  • Alan D. Irvine, MD

      Affiliations

    • Department of Pediatric Dermatology, Our Lady's Children's Hospital, Dublin, Ireland
    • Department of Clinical Medicine, Trinity College Dublin, Ireland

References 

  1. Rogers AJ, Celedon JC, Lasky-Su JA, Weiss ST, Raby BA. Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma. J Allergy Clin Immunol. 2007;120:1332–1337
  2. Irvine AD. Fleshing out filaggrin phenotypes. J Invest Dermatol. 2007;127:504–507
  3. Baurecht H, Irvine AD, Novak N, Illig T, Buhler B, Ring J, et al. Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J Allergy Clin Immunol. 2007;120:1406–1412
  4. Marenholz I, Nickel R, Ruschendorf F, Schulz F, Esparza-Gordillo J, Kerscher T, et al. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol. 2006;118:866–871
  5. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38:441–446
  6. Henderson J, Northstone K, Lee SP, Liao H, Zhao Y, Pembrev M, et al. The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol. 2008;121:872–877
  7. Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, et al. Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol. 2008;In press
  8. Hudson TJ. Skin barrier function and allergic risk. Nat Genet. 2006;38:399–400
  9. Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, Debenedetto A, et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 2007;120:150–155
  10. Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113:925–931

 Disclosure of potential conflict of interest: A. D. Irvine has received research support from the Children's Medical and Research Foundation and has served as an expert witness in industrial dermatitis litigation. J. Henderson has received research support from the Medical Research Council and Asthma UK. M. Kabesch has received research support from Gabriel, European Union, National Genome Research Network German Federal Ministry of Education and Research, and Sonderforschungsbereich TR22 Deutsche Forschungsgemeinschaft and has served as a member of the European Research Society. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00551-4

doi: 10.1016/j.jaci.2008.02.039

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 5 , Pages 1294-1295 , May 2008

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