The Journal of Allergy and Clinical Immunology
Volume 121, Issue 5 , Pages 1133-1139.e1 , May 2008

Acute respiratory health effects of air pollution on children with asthma in US inner cities

  • George T. O'Connor, MD, MS

      Affiliations

    • Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Mass
    • Corresponding Author InformationReprint requests: George T. O'Connor, MD, MS, Boston University School of Medicine, Pulmonary Center, 715 Albany St, Room 304, Boston, MA 02118.
  • ,
  • Lucas Neas, DSc

      Affiliations

    • US Environmental Protection Agency, Research Triangle Park, NC
  • ,
  • Benjamin Vaughn, MS

      Affiliations

    • Rho Federal Systems Division, Inc, Chapel Hill, NC
  • ,
  • Meyer Kattan, MD

      Affiliations

    • Department of Pediatrics, Mount Sinai School of Medicine, New York, NY
  • ,
  • Herman Mitchell, PhD

      Affiliations

    • US Environmental Protection Agency, Research Triangle Park, NC
  • ,
  • Ellen F. Crain, MD

      Affiliations

    • Department of Pediatrics (Emergency Medicine), Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY
  • ,
  • Richard Evans III, MD

      Affiliations

    • Departments of Pediatrics and Medicine, Northwestern University Medical School, Chicago, Ill
    • Deceased.
  • ,
  • Rebecca Gruchalla, MD, PhD

      Affiliations

    • Departments of Medicine and Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex
  • ,
  • Wayne Morgan, MD

      Affiliations

    • Respiratory Sciences Center, University of Arizona College of Medicine, Tucson, Ariz
  • ,
  • James Stout, MD

      Affiliations

    • Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash
  • ,
  • G. Kenneth Adams, MD

      Affiliations

    • National Institute of Allergy and Infectious Diseases, Bethesda, Md
    • Retired.
  • ,
  • Morton Lippmann, PhD

      Affiliations

    • Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY

Received 22 August 2007 ,Revised 11 February 2008 ,Accepted 11 February 2008.

References 

  1. Burnett RT, Brook J, Dann T, Delocla C, Philips O, Cakmak S, et al. Association between particulate- and gas-phase components of urban air pollution and daily mortality in eight Canadian cities. Inhal Toxicol. 2000;12:15–39
  2. Schwartz J, Dockery DW, Neas LM. Is daily mortality associated specifically with fine particles?. J Air Waste Manage Assoc. 1996;46:927–939
  3. Sheppard L, Levy D, Norris G, Larson TV, Koenig JQ. Effects of ambient air pollution on nonelderly asthma hospital admissions in Seattle, Washington, 1987-1994. Epidemiology. 1999;10:23–30
  4. US Environmental Protection Agency . Air quality criteria for particulate matter. EPA/600/P-99/002aF. Research Triangle Park (NC): National Center for Environmental Assessment-RTP Office; 2004;
  5. Norris G, YoungPong SN, Koenig JQ, Larson TV, Sheppard L, Stout JW. An association between fine particles and asthma emergency department visits for children in Seattle. Environ Health Perspect. 1999;107:489–493
  6. White MC, Etzel RA, Wilcox WD, Lloyd C. Exacerbations of childhood asthma and ozone pollution in Atlanta. Environ Res. 1994;65:56–68
  7. Barnett AG, Williams GM, Schwartz J, Neller AH, Best TL, Petroeschevsky AL, et al. Air pollution and child respiratory health: a case-crossover study in Australia and New Zealand. Am J Respir Crit Care Med. 2005;171:1272–1278
  8. Phalen RF. The particulate air pollution controversy: a case study and lessons Learned. Boston: Kluwer; 2002;
  9. Neas LM, Dockery DW, Koutrakis P, Tollerud DJ, Speizer FE. The association of ambient air-pollution with twice-daily peak expiratory flow-rate measurements in children. Am J Epidemiol. 1995;141:111–122
  10. Schwartz J, Neas LM. Fine particles are more strongly associated than coarse particles with acute respiratory health effects in schoolchildren. Epidemiology. 2000;11:6–10
  11. Spektor DM, Lippmann M, Lioy PJ, Thurston GD, Citak K, James DJ, et al. Effects of ambient ozone on respiratory function in active, normal children. Am Rev Respir Dis. 1988;137:313–320
  12. Delfino RJ, Zeiger RS, Seltzer JM, Street DH. Symptoms in pediatric asthmatics and air pollution: differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time. Environ Health Perspect. 1998;106:751–761
  13. Pekkanen J, Timonen KL, Ruuskanen J, Reponen A, Mirme A. Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms. Environ Res. 1997;74:24–33
  14. Peters A, Dockery DW, Heinrich J, Wichmann HE. Short-term effects of particulate air pollution on respiratory morbidity in asthmatic children. Eur Respir J. 1997;10:872–879
  15. Tiittanen P, Timonen KL, Ruuskanen J, Mirme A, Pekkanen J. Fine particulate air pollution, resuspended road dust and respiratory health among symptomatic children. Eur Respir J. 1999;13:266–273
  16. Friedman MS, Powell KE, Hutwagner L, Graham LM, Teague WG. Impact of changes in transportation and commuting behaviors during the 1996 Summer Olympic Games in Atlanta on air quality and childhood asthma. JAMA. 2001;285:897–905
  17. Ostro B, Lipsett M, Mann J, Braxton-Owens H, White M. Air pollution and exacerbation of asthma in African-American children in Los Angeles. Epidemiology. 2001;12:200–208
  18. Thurston GD, Lippmann M, Scott MB, Fine JM. Summertime haze air pollution and children with asthma. Am J Respir Crit Care Med. 1997;155:654–660
  19. Mortimer KM, Neas LM, Dockery DW, Redline S, Tager IB. The effect of air pollution on inner-city children with asthma. Eur Respir J. 2002;19:699–705
  20. Ward DJ, Ayres JG. Particulate air pollution and panel studies in children: a systematic review. Occup Environ Med. 2004;61:e13
  21. Romieu I, Meneses F, Ruiz S, Sienra JJ, Huerta J, White MC, et al. Effects of air pollution on the respiratory health of asthmatic children living in Mexico City. Am J Respir Crit Care Med. 1996;154:300–307
  22. Neas LM, Dockery DW, Koutrakis P, Speizer FE. Fine particles and peak flow in children: acidity versus mass. Epidemiology. 1999;10:550–553
  23. Gold DR, Damokosh AI, Pope CA, Dockery DW, McDonnell WF, Serrano P, et al. Particulate and ozone pollutant effects on the respiratory function of children in southwest Mexico City. Epidemiology. 1999;10:8–16
  24. Ward DJ, Roberts KT, Jones N, Harrison RM, Ayres JG, Hussain S, et al. Effects of daily variation in outdoor particulates and ambient acid species in normal and asthmatic children. Thorax. 2002;57:489–502
  25. Pope CA, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002;287:1132–1141
  26. Slaughter JC, Lumley T, Sheppard L, Koenig JQ, Shapiro GG. Effects of ambient air pollution on symptom severity and medication use in children with asthma. Ann Allergy Asthma Immunol. 2003;91:346–353
  27. Krewski D, Rainham D. Ambient air pollution and population health: overview. J Toxicol Environ Health A. 2007;70:275–283
  28. Delfino RJ, Gong H, Linn WS, Pellizzari ED, Hu Y. Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environ Health Perspect. 2003;111:647–656
  29. Crain EF, Walter M, O'Connor GT, Mitchell H, Gruchalla RS, Kattan M, et al. Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study. Environ Health Perspect. 2002;110:939–945
  30. Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans RI, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004;351:1068–1080
  31. Hsu KH, Jenkins DE, Hsi BP, Bourhofer E, Thompson V, Tanakawa N, et al. Ventilatory functions of normal children and young adults–Mexican-American, white, and black, I: spirometry. J Pediatr. 1979;95:14–23
  32. US Environmental Protection Agency. Technology Transfer Network - Air Quality System. U.S.Environmental Protection Agency. Available at: http://www.epa.gov/ttn/airs/airsaqs/. Accessed March 27, 2008.
  33. Zanobetti A, Schwartz J, Dockery DW. Airborne particles are a risk factor for hospital admissions for heart and lung disease. Environ Health Perspect. 2000;108:1071–1077
  34. Sinclair AH, Tolsma D. Associations and lags between air pollution and acute respiratory visits in an ambulatory care setting: 25-month results from the aerosol research and inhalation epidemiological study. J Air Waste Manag Assoc. 2004;54:1212–1218
  35. Pope CI, Dockery DW. Acute health effects of PM pollution on symptomatic and asymptomatic children. Am Rev Respir Dis. 1992;145:1123–1128
  36. McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, et al. Prospective study of air pollution and bronchitic symptoms in children with asthma. Am J Respir Crit Care Med. 2003;168:790–797
  37. Venn AJ, Lewis SA, Cooper M, Hubbard R, Britton J. Living near a main road and the risk of wheezing illness in children. Am J Respir Crit Care Med. 2001;164:2177–2180
  38. Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet. 2002;360:1203–1209
  39. Laden F, Neas LM, Dockery DW, Schwartz J. Association of fine particulate matter from different sources with daily mortality in six US cities. Environ Health Perspect. 2000;108:941–947
  40. Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J. Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med. 1997;155:1376–1383
  41. Sarnat JA, Koutrakis P, Suh HH. Assessing the relationship between personal particulate and gaseous exposures of senior citizens living in Baltimore, MD. J Air Waste Manage Assoc. 2000;50:1184–1198
  42. Belanger K, Gent JF, Triche EW, Bracken MB, Leaderer BP. Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma. Am J Respir Crit Care Med. 2006;173:297–303
  43. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004;351:1057–1067
  44. Ito K, DeLeon S, Thurston G, Nadas A, Lippmann M. Monitor to monitor temporal correlation of air pollution in the contiguous US. J Expos Anal Environ Epidemiol. 2005;15:173–184

 Supported by grants AI-39769, AI-39900, AI-39902, AI-39789, AI-39901, AI-39761, AI-39785, and AI-39776 from the National Institute of Allergy and Infectious Diseases and the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services; and by grant M01 RR00533 from the National Center for Research Resources, National Institutes of Health, Department of Health and Human Services; with partial support provided by the US Environmental Protection Agency through an interagency agreement with the National Institute of Allergy and Infectious Diseases. The manuscript has been subjected to agency review and approved for publication. The opinions expressed here do not necessarily reflect US Environmental Protection Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

 Disclosure of potential conflict of interest: R. Gruchalla has received research support from Novartis. W. Morgan has consulting arrangements with the Cystic Fibrosis Foundation; has patent licensing arrangements with the Childhood Asthma Research and Education Network and the National Heart, Lung, and Blood Institute; has received research support from the Cystic Fibrosis Foundation and the National Institute of Allergy and Infectious Diseases; and is on the advisory board for Genentech. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(08)00407-7

doi: 10.1016/j.jaci.2008.02.020

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 5 , Pages 1133-1139.e1 , May 2008