The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 607-613 , March 2008

Natural history of asthma: Persistence versus progression—does the beginning predict the end?

  • Reynold A. Panettieri Jr., MD

      Affiliations

    • Pulmonary, Allergy & Critical Care Division, University of Pennsylvania, Philadelphia, Pa
    • Corresponding Author InformationReprint requests: Reynold A. Panettieri, Jr, MD, Department of Medicine, University of Pennsylvania School of Medicine, Pulmonary, Allergy & Critical Care Division, and Airways Biology Initiative, 125 South 31st St, TRL Suite 1200, Room 1211, Philadelphia, PA 19104-3403.
    • ,
  • Ronina Covar, MD

      Affiliations

    • Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Divisions of Pediatric Clinical Pharmacology and Allergy-Clinical Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo
    • ,
  • Evalyn Grant, MD

      Affiliations

    • Merck & Co, Inc, West Point, Pa
    • ,
  • Elizabeth V. Hillyer, DVM

      Affiliations

    • Bernardsville, NJ
    • ,
  • Leonard Bacharier, MD

      Affiliations

    • Department of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo

Received 30 October 2007 ,Revised 7 January 2008 ,Accepted 9 January 2008.

  • Image Result

    FEV1 percent predicted at ages 7, 10, 14, 21, 28, 35, and 42 years in the Melbourne study subjects in their recruitment groups. Modified with permission from Phelan PD, Robertson CF, Olinsky A. The Me

    FEV1 percent predicted at ages 7, 10, 14, 21, 28, 35, and 42 years in the Melbourne study subjects in their recruitment groups. Modified with permission from Phelan PD, Robertson CF, Olinsky A. The Melbourne Asthma Study: 1964-1999. J Allergy Clin Immunol 2002;109:189-94.2

  • Image Result
    Integrative model of the components of airway remodeling. In patients with asthma, airway inflammation, epithelial and goblet cell phenotype alterations, subepithelial fibrosis, excess mucus secretion

    Integrative model of the components of airway remodeling. In patients with asthma, airway inflammation, epithelial and goblet cell phenotype alterations, subepithelial fibrosis, excess mucus secretion, smooth muscle cell hypertrophy and hyperplasia, and angiogenesis are present. Copyright 2003, Ethan F. Geehr, reprinted with permission.

 Elizabeth Hillyer was supported by Merck & Co, Inc, Whitehouse Station, NJ.

 Disclosure of potential conflict of interest: R. Covar has received research support from AstraZeneca and Ross Abbott Laboratories, Inc. E. V. Hillyer has received freelance writing work from Merck and Aerocrine. L. Bacharier has consulting arrangements with Schering-Plough and is on the speakers' bureau for AstraZeneca, Genentech, GlaxoSmithKline, and Merck. The rest of the authors have declared that they have no conflict of interest.

 This article originated, in part, from a discussion at the National Respiratory Experts Forum, held June 15-17, 2006, in Chicago, IL. This was a scientific forum, sponsored by Merck, where specific topics and questions were explored for issues pertinent to the fields of asthma and respiratory medicine.

PII: S0091-6749(08)00134-6

doi: 10.1016/j.jaci.2008.01.006

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 607-613 , March 2008

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