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The Journal of Allergy and Clinical Immunology
Volume 121, Issue 2
, Pages 309-319
, February 2008
Not miR-ly small RNAs: Big potential for microRNAs in therapy
References
- . Vertebrate microRNA genes. Science. 2003;299:1540
- . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15–20
- . MicroRNAs and their regulatory roles in animals and plants. J Cell Physiol. 2007;210:279–289
- . Oncomirs: microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259–269
- Combinatorial microRNA target predictions. Nat Genet. 2005;37:495–500
- . A microRNA in a multiple-turnover RNAi enzyme complex. Science. 2002;297:2056–2060
- . Antisense technologies: improvement through novel chemical modifications. Eur J Biochem. 2003;270:1628–1644
- . Ribozyme- and deoxyribozyme-strategies for medical applications. Curr Drug Targets. 2004;5:667–681
- RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003;9:347–351
- Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006;441:537–541
- . First clinical data on RNAi. Drug Discovery Today. 2005;10:1014–1015
- Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 2003;21:635–637
- . On the art of identifying effective and specific siRNAs. Nat Methods. 2006;3:670–676
- . Design of active small interfering RNAs. Curr Opin Mol Ther. 2007;9:110–118
- Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing. RNA. 2006;12:1197–1205
- . Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol Cell Biol. 1992;12:5238–5248
- . Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through Toll-like receptor 3. J Immunol. 2004;172:6545–6549
- . Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol. 2005;23:222–226
- Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol. 2005;23:227–231
- Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA. 2006;12:988–993
- . Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet. 2003;34:263–264
- . Activation of the interferon system by short-interfering RNAs. Nat Cell Biol. 2003;5:834–839
- . Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005;23:457–462
- Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11:263–270
- . Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol. 2005;348:1079–1090
- . Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther. 2006;13:494–505
- . Why do we need new gene therapy viral vectors? characteristics, limitations and future perspectives of viral vector transduction. Curr Gene Ther. 2004;4:357–372
- Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol. 2001;19:1444–1454
- Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma. J Clin Oncol. 2005;23:3495–3501
- . Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 2001;19:424–436
- . DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J. 2005;7:E61–E77
- A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther. 2006;13:1222–1234
- An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006;439:89–94
- . Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo. J Pharm Pharmacol. 2002;54:593–601
- . Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release. 2006;114:100–109
- . Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun. 2003;312:1220–1225
- . Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun. 2005;330:755–759
- Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology. 2005;41:1349–1356
- Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer. Cancer Biol Ther. 2006;5:1708–1713
- Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 2006;12:939–944
- Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin Cancer Res. 2006;12:4916–4924
- . Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. J Biotechnol. 2006;124:12–25
- Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 2004;432:173–178
- . Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol. 2006;6:509–514
- . siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene. J Control Release. 2006;112:229–239
- . Delivery of short interfering RNA using endosomolytic cell-penetrating peptides. FASEB J. 2007;21:2664–2671
- Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005;23:709–717
- Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery. Hepatology. 2007;46:84–94
- CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci U S A. 2007;104:11008–11013
- Transvascular delivery of small interfering RNA to the central nervous system. Nature. 2007;448:39–43
- The Trp cage motif as a scaffold for the display of a randomized peptide library on bacteriophage T7. J Biol Chem. 2007;282:9813–9824
- . RNA learns from antisense. Nat Chem Biol. 2007;3:8–11
- . MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6:857–866
- . siRNAs can function as miRNAs. Genes Dev. 2003;17:438–442
- . Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell. 2002;110:563–574
- . Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. Clin Cancer Res. 2006;12:6557–6564
- . Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA. 2004;10:544–550
- . Sequence-specific inhibition of small RNA function. PLoS Biol. 2004;2:E98
- . MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005;65:6029–6033
- . Depletion of human microRNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem. 2005;280:16635–16641
- Silencing of microRNAs in vivo with “antagomirs.”. Nature. 2005;438:685–689
- miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3:87–98
- . Target protectors reveal dampening and balancing of nodal agonist and antagonist by miR-430. Science. 2007;318:271–274
- . MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83–86
- . Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 2007;21:578–589
- miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 2007;129:147–161
- . T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity. 2006;25:261–270
- . A small microRNA makes a Bic difference. Genome Biol. 2007;8:221;1-4
- Requirement of bic/microRNA-155 for normal immune function. Science. 2007;316:608–611
- Regulation of the germinal center response by microRNA-155. Science. 2007;316:604–608
- . NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12481–12486
- MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005;6:R71;1-15
- Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Human Mol Genet. 1998;7:1393–1398
- MicroRNAs: novel regulators involved in the pathogenesis of Psoriasis?. PLoS ONE. 2007;2:e610
- Topical matrix-based siRNA silences local gene expression in a murine wound model. Gene Ther. 2007;14:1305–1308
- Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99:15524–15529
- Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004;101:2999–3004
- . High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer. 2004;39:167–169
- Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A. 2005;102:3627–3632
- A microRNA polycistron as a potential human oncogene. Nature. 2005;435:828–833
- MicroRNA expression profiles classify human cancers. Nature. 2005;435:834–838
- . Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis. J Virol. 2002;76:4275–4286
- A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell. 2005;123:819–831
- MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A. 2005;102:18081–18086
- MicroRNA Let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res. 2007;67:9762–9770
- RAS is regulated by the let-7 microRNA family. Cell. 2005;120:635–647
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.
PII: S0091-6749(07)03617-2
doi: 10.1016/j.jaci.2007.12.1167
© 2008 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
« Previous
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The Journal of Allergy and Clinical Immunology
Volume 121, Issue 2
, Pages 309-319
, February 2008
