The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 725-730.e2 , March 2008

Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity

  • Jayanta Gupta, MD

      Affiliations

    • Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • Institute of Personalized and Predictive Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Emilie Grube, BA

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Mark B. Ericksen, BS

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • Institute of Personalized and Predictive Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Michelle D. Stevenson, MD, MS

      Affiliations

    • Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Anne W. Lucky, MD

      Affiliations

    • Division of Pediatric Dermatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Anita P. Sheth, MD

      Affiliations

    • Division of Pediatric Dermatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Amal H. Assa'ad, MD

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Gurjit K. Khurana Hershey, MD, PhD

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • Institute of Personalized and Predictive Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • Corresponding Author InformationReprint requests: Gurjit K. Khurana Hershey, MD, PhD, Institute of Personalized and Predictive Medicine and Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7028, Cincinnati, OH 45229.

Received 1 October 2007 ,Revised 14 December 2007 ,Accepted 17 December 2007.

  • Image Result

    Comparison of TEWL measured at the volar forearm between white and African American children. Gray bars, Median TEWL in white children; black bars, median TEWL in African American children. Error bars

    Comparison of TEWL measured at the volar forearm between white and African American children. Gray bars, Median TEWL in white children; black bars, median TEWL in African American children. Error bars represent semi-interquartile range. All P values were obtained by using the Wilcoxon rank sum test.

  • Image Result
    Comparison of TEWL between white (A) or African American (B) children with AD and racially matched control groups. White bars, Median TEWL in AD cases; gray bars, median TEWL in healthy control subjec

    Comparison of TEWL between white (A) or African American (B) children with AD and racially matched control groups. White bars, Median TEWL in AD cases; gray bars, median TEWL in healthy control subjects; black bars, median TEWL in allergic control subjects. ∗P < .0004 compared with AD cases. †P < .05 compared with AD cases. Error bars represent semi-interquartile range. All P values were obtained by using the Wilcoxon rank-sum test with the Bonferroni correction for multiple comparisons.

  • Image Result
    Scatter plot demonstrating correlation between TEWL and objective SCORAD score in white (A) or African American (B) children with AD (Spearman coefficient of 0.41 and P value of .001 in white subjects

    Scatter plot demonstrating correlation between TEWL and objective SCORAD score in white (A) or African American (B) children with AD (Spearman coefficient of 0.41 and P value of .001 in white subjects; Spearman coefficient of 0.38 and P value of .003 in African American subjects).

  • Image Result
    Comparison of TEWL between children with AD with positive and children with AD with negative allergy test results (A, white children; B, African American children). Black bars, Median TEWL in AD cases

    Comparison of TEWL between children with AD with positive and children with AD with negative allergy test results (A, white children; B, African American children). Black bars, Median TEWL in AD cases with positive allergy test results; gray bars, median TEWL in AD cases with negative allergy test results. Error bars represent semi-interquartile range. None of the P values (obtained by using the Wilcoxon rank sum test) were statistically significant.

  • Image Result
    Comparison of TEWL between AD cases without asthma/allergic rhinitis and AD cases with asthma/allergic rhinitis (A, white subjects; B, African American subjects). Black bars, Median TEWL in AD cases w

    Comparison of TEWL between AD cases without asthma/allergic rhinitis and AD cases with asthma/allergic rhinitis (A, white subjects; B, African American subjects). Black bars, Median TEWL in AD cases without asthma/allergic rhinitis; gray bars, median TEWL in AD cases with asthma/allergic rhinitis. Error bars represent semi-interquartile range. None of the P values (obtained by using the Wilcoxon rank sum test) were statistically significant.

 Supported by National Institutes of Health grant U19A170235-01 (GKKH) and the University of Cincinnati, Molecular Epidemiology in Children's Environmental Health–Institutional NIEHS T32 ES10957 (MDS) and Cincinnati Children's Hospital Medical Center–Institutional NICHD T32 HD43005 (MDS).

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)03611-1

doi: 10.1016/j.jaci.2007.12.1161

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 725-730.e2 , March 2008

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