The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 646-651 , March 2008

Sensitization does not develop in utero

  • Klaus Bønnelykke, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Klaus Bønnelykke, MD, Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark.
    • ,
  • Christian Bressen Pipper, MSc, PhD
    • ,
  • Hans Bisgaard, MD, DMSc

Received 23 October 2007 ,Revised 29 November 2007 ,Accepted 10 December 2007.

  • Image Result

    Patterns of specific IgE in individual mother–cord blood pairs. The gray rectangle in the cord blood diagrams represents lower limit of IgE detection (0.1 IU/mL). CB, Cord blood. Allergen abbreviation

    Patterns of specific IgE in individual mother–cord blood pairs. The gray rectangle in the cord blood diagrams represents lower limit of IgE detection (0.1 IU/mL). CB, Cord blood. Allergen abbreviations: a, cat dander; b, dog dander; c, D pteronyssinus; d, mugwort; e, birch; f, grass; g, egg white; h, milk; i, peanut. Pairs are listed in order of increasing level of cord blood IgA.

  • Image Result
    Relation between IgA and specific IgE (against mixed allergens) in cord blood. Regression line is shown.

    Relation between IgA and specific IgE (against mixed allergens) in cord blood. Regression line is shown.

  • Image Result
    Relation between IgA and specific IgE (sum of specific IgE against single allergens) in cord blood. Regression line is shown.

    Relation between IgA and specific IgE (sum of specific IgE against single allergens) in cord blood. Regression line is shown.

  • Image Result
    Relation between specific IgE (against mixed allergens) in cord blood and specific IgE in maternal blood, stratified for level of IgA in cord blood. Regression lines are shown for each level of cord b

    Relation between specific IgE (against mixed allergens) in cord blood and specific IgE in maternal blood, stratified for level of IgA in cord blood. Regression lines are shown for each level of cord blood IgA.

    — and ● Cord blood IgA > 100 μg/L

    — and ● Cord blood IgA = 50-100 μg/L

    — and ● Cord blood IgA < 50 μg/L.

  • Image Result
    Relation between specific IgE in cord blood (sum of specific IgE against single allergens) and specific IgE in maternal blood, stratified for level of IgA in cord blood. Regression lines are shown for

    Relation between specific IgE in cord blood (sum of specific IgE against single allergens) and specific IgE in maternal blood, stratified for level of IgA in cord blood. Regression lines are shown for each level of cord blood IgA.

    — and ● Cord blood IgA > 100 μg/L

    — and ● Cord blood IgA = 50-100 μg/L

    — and ● Cord blood IgA < 50 μg/L.

  • Image Result
    Relation between ratios of total/specific IgE in maternal blood and cord blood.

    Relation between ratios of total/specific IgE in maternal blood and cord blood.

 The IgE analyses were supported by Phadia ApS. The Copenhagen Study on Asthma in Childhood is funded by research funds: the Pharmacy Foundation of 1991; the Lundbeck Foundation; the Augustinus Foundation; Ronald McDonald House Charities; the Danish Medical Research Council; the Danish Pediatric Asthma Center; Direktør, cand.pharm. K. Gad Andersen og Hustrus Familiefond; Aage Bangs Fond; the Danish Lung Association; Kai Lange og Gunhild Kai Langes Fond; Direktør Ib Henriksens Fond; Gerda og Aage Hensch's Fond; Rosalie Petersens Fond; Hans og Nora Buchards Fond; Dagmar Marshalls Fond; the Foundation of Queen Louise Children's Hospital; the Danish Hospital Foundation for Medical Research, Region of Copenhagen, the Faroe Island, and Greenland; Gangsted Fond; Højmosegård-Legatet; Fonden til Lægevidenskabens Fremme; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; and the Danish Ministry of the Interior and Health's Research Center for Environmental Health. The study received support from the following pharmaceutical companies: AstraZeneca, LEOpharma, and Yamanouchi Pharma.

 Disclosure of potential conflict of interest: K. Bønnelykke has received travel grants from Phadia ApS. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)03576-2

doi: 10.1016/j.jaci.2007.12.1149

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 646-651 , March 2008

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