The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 731-736 , March 2008

Early clinical predictors of remission of peanut allergy in children

  • Marco H.K. Ho, MD

      Affiliations

    • Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia
  • ,
  • Wilfred H.S. Wong, MMedSc

      Affiliations

    • Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
  • ,
  • Ralf G. Heine, MD

      Affiliations

    • Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia
    • Murdoch Children's Research Institute, Melbourne, Australia
    • Department of Pediatrics, The University of Melbourne, Melbourne, Australia
  • ,
  • Clifford S. Hosking, MD

      Affiliations

    • John Hunter Children's Hospital, Newcastle, Australia
  • ,
  • David J. Hill, MD

      Affiliations

    • Murdoch Children's Research Institute, Melbourne, Australia
  • ,
  • Katrina J. Allen, MD, PhD

      Affiliations

    • Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia
    • Murdoch Children's Research Institute, Melbourne, Australia
    • Department of Pediatrics, The University of Melbourne, Melbourne, Australia
    • Corresponding Author InformationReprint requests: Katrina J. Allen, MD, PhD, Pediatric Gastroenterologist/Allergist, Department of Allergy and Immunology, Royal Children's Hospital, Flemington Rd, Parkville Vic 3052, Australia.

Received 16 June 2007 ,Revised 10 October 2007 ,Accepted 16 November 2007.

References 

  1. Hill DJ, Hosking CS, Zhie CY, Leung R, Baratwidjaja K, Likura Y, et al. The frequency of food allergy in Australia and Asia. Environ Toxicol Pharmacol. 1997;4:101–110
  2. Rance F, Grandmottet X, Grandjean H. Prevalence and main characteristics of schoolchildren diagnosed with food allergies in France. Clin Exp Allergy. 2005;35:167–172
  3. Hourihane JO, Aiken RA, Briggs R, Gudgeon LA, Grimshaw KE, Dunn-Galvin A, et al. The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry. J Allergy Clin Immunol. 2007;119:1197–1202
  4. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207
  5. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491–503
  6. Kagan RS, Joseph L, Dufresne C, Gray-Donald K, Turnbull E, Pierre YS, et al. Prevalence of peanut allergy in primary-school children in Montreal, Canada. J Allergy Clin Immunol. 2003;112:1223–1228
  7. Hourihane JB, Kilburn SA, Nordlee JA, Hefle SL, Taylor SL, Warner JO. An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study. J Allergy Clin Immunol. 1997;100:596–600
  8. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6
  9. Vander Leek TK, Liu AH, Stefanski K, Blacker B, Bock SA. The natural history of peanut allergy in young children and its association with serum peanut-specific IgE. J Pediatr. 2000;137:749–755
  10. Sicherer SH, Furlong TJ, Munoz-Furlong A, Burks AW, Sampson HA. A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants. J Allergy Clin Immunol. 2001;108:128–132
  11. Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol. 2001;107:367–374
  12. Hourihane JO, Roberts SA, Warner JO. Resolution of peanut allergy: case-control study. BMJ. 1998;316:1271–1275
  13. Fleischer DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. The natural progression of peanut allergy: resolution and the possibility of recurrence. J Allergy Clin Immunol. 2003;112:183–189
  14. Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol. 2004;15:435–441
  15. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30:1540–1546
  16. Ho MH, Heine RG, Wong W, Hill DJ. Diagnostic accuracy of skin prick testing for tree nut allergy in children. J Allergy Clin Immunol. 2006;117:1506–1508
  17. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100:444–451
  18. Celik-Bilgili S, Mehl A, Verstege A, Staden U, Nocon M, Beyer K, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy. 2005;35:268–273
  19. Roberts G, Lack G, the Avon longitudinal study of parents and children study team . Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol. 2005;115:1291–1296
  20. Ewan PW, Clarke AT. Efficacy of a management plan based on severity assessment in longitudinal and case-controlled studies 747 children with nut allergy. Clin Exp Allergy. 2005;35:751–756
  21. De Leon MP, Drew AC, Glaspole IN, Suphioglu C, Rolland JM, O'Hehir RE. Functional analysis of corss-reactive immunoglobulin E antibodies: peanut-specific immunoglobulin E sensitizes basophils to tree nut allergens. Clin Exp Allergy. 2005;35:1056–1064
  22. Beardslee TA, Zeece MG, Sarath G, Markwell JP. Soybean glycinin G1 acidic chain shares IgE epitopes with peanut allergen Ara h 3. Int Arch Allergy Immunol. 2000;123:299–307
  23. Hill DJ, Hosking CS, Reyes-Benito LV. Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests. Clin Exp Allergy. 2001;31:1031–1035
  24. Hill DJ, Heine RG, Hosking CS. Management of peanut and nut allergies. Lancet. 2001;357:87–88
  25. Hill DJ, Hosking CS. Food allergy and atopic dermatitis in infancy: an epidemiologic study. Pediatr Allergy Immunol. 2004;15:421–427
  26. Astier C, Morisset M, Roitel O, Codreanu F, Jacquenet S, Franck P, et al. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol. 2006;118:250–256

 Dr Ho was supported by the Ho Hung Chiu Medical Education Scholarship and training grant of the Hospital Authority, Hong Kong SAR, China. Dr Allen is a recipient of an Australian National Health and Medical Research Council Career Development Award and has funding from the Ilhan Food Allergy Foundation and AnaphylaxiStop.

 Disclosure of potential conflict of interest: The authors have declared that they have no relevant conflict of interest.

PII: S0091-6749(07)02262-2

doi: 10.1016/j.jaci.2007.11.024

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 3 , Pages 731-736 , March 2008