The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 116-121.e11 , January 2008

Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis

  • Joohee Lee, AB

      Affiliations

    • University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, NJ
    • ,
  • David Seto, BA

      Affiliations

    • University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, NJ
    • ,
  • Leonard Bielory, MD

      Affiliations

    • Department of Medicine, UMDNJ–New Jersey Medical School, Newark, NJ
    • Corresponding Author InformationReprint requests: Leonard Bielory, MD, Department of Medicine, UMDNJ–New Jersey Medical School, 90 Bergen Street, DOC Suite 4700, Newark, NJ 07103-2499.

Received 6 August 2007 ,Revised 2 October 2007 ,Accepted 26 October 2007.

References 

  1. Isolauri E. Dietary modification of atopic disease: use of probiotics in the prevention of atopic dermatitis. Curr Allergy Asthma Rep. 2004;4:270–275
  2. Prescott SL, Bjorksten B. Probiotics for the prevention or treatment of allergic diseases. J Allergy Clin Immunol. 2007;120:255–262
  3. Boyle RJ, Tang ML. The role of probiotics in the management of allergic disease. Clin Exp Allergy. 2006;36:568–576
  4. Rautava S, Kalliomaki M, Isolauri E. New therapeutic strategy for combating the increasing burden of allergic disease: Probiotics-A Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota (NAMI) Research Group report. J Allergy Clin Immunol. 2005;116:31–37
  5. Ogden NS, Bielory L. Probiotics: a complementary approach in the treatment and prevention of pediatric atopic disease. Curr Opin Allergy Clin Immunol. 2005;5:179–184
  6. Yusuf S. Meta-analysis of randomized trials: looking back and looking ahead. Control Clin Trials. 1997;18:594–601discussion 61-6
  7. Helfenstein U. Data and models determine treatment proposals: an illustration from meta-analysis. Postgrad Med J. 2002;78:131–134
  8. Cho M, Bero L. Instruments for assessing the quality of drug studies published in the medical literature. JAMA. 1994;272:101–104
  9. Jadal AR, Moore AR, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17:1–12
  10. Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol. 1998;51:1235–1241
  11. Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997;99:179–185
  12. Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000;30:1604–1610
  13. Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy. 2005;60:494–500
  14. Weston S, Halbert A, Richmond P, Prescott SL. Effects of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child. 2005;90:892–897
  15. Rosenfeldt V, Benfeldt E, Nielsen SD, Michaelsen KF, Jeppesen DL, Valerius NH, et al. Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol. 2003;111:389–395
  16. Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. Is the effect of probiotics on atopic dermatitis confined to food sensitized children?. Clin Exp Allergy. 2006;36:629–633
  17. Brouwer ML, Wolt-Plompen SA, Dubois AE, van der Heide S, Jansen DF, Hoijer MA, et al. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy. 2006;36:899–906
  18. Pelto L, Isolauri E, Lilius EM, Nuutila J, Salminen S. Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clin Exp Allergy. 1998;28:1474–1479
  19. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2007;119:192–198
  20. Rautava S, Kalliomaki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol. 2002;109:119–121
  21. O'Sullivan GC, Kelly P, O'Halloran S, Collins C, Collins JK, Dunne C, et al. Probiotics: an emerging therapy. Curr Pharm Des. 2005;11:3–10
  22. Cucchiara S, Falconieri P, Di Nardo G, Parcelii MA, Dito L, Grandinetti A. New therapeutic approach in the management of intestinal disease: probiotics in intestinal disease in paediatric age. Dig Liv Dis. 2002;34:S44–S47

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)02172-0

doi: 10.1016/j.jaci.2007.10.043

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 116-121.e11 , January 2008

Article Tools

* Image Usage & Resolution