The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 116-121.e11 , January 2008

Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis

  • Joohee Lee, AB

      Affiliations

    • University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, NJ
    • ,
  • David Seto, BA

      Affiliations

    • University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, NJ
    • ,
  • Leonard Bielory, MD

      Affiliations

    • Department of Medicine, UMDNJ–New Jersey Medical School, Newark, NJ
    • Corresponding Author InformationReprint requests: Leonard Bielory, MD, Department of Medicine, UMDNJ–New Jersey Medical School, 90 Bergen Street, DOC Suite 4700, Newark, NJ 07103-2499.

Received 6 August 2007 ,Revised 2 October 2007 ,Accepted 26 October 2007.

  • Image Result

    Flowchart of process of study selection for meta-analysis.

    Flowchart of process of study selection for meta-analysis.

  • Image Result

    Pooled statistical analyses of primary and secondary prevention trials using RevMan. Prevention studies were assessed by using both FE and RE models of relative risk. The treatment studies were assess

    Pooled statistical analyses of primary and secondary prevention trials using RevMan. Prevention studies were assessed by using both FE and RE models of relative risk. The treatment studies were assessed in terms of intragroup and intergroup SCORAD change also using both models of WMD. Studies are ordered from top to bottom in descending order of MQ quality ranking.

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    Ranking list of prevention and treatment clinical trials using Cho & Bero's MQ scale. Fisher analysis of ranking results from the 4 quality scales indicated that this scale had the best interobserver;

    Ranking list of prevention and treatment clinical trials using Cho & Bero's MQ scale. Fisher analysis of ranking results from the 4 quality scales indicated that this scale had the best interobserver and interscale reliability. The quartile status allows gauging of the relative quality of these 2 interventional approaches. Boldface studies are those that were meta-analyzed.

  • Image Result
    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.;

    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.

  • Image Result
    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.;

    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.

  • Image Result
    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.;

    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.

  • Image Result
    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.;

    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.

  • Image Result
    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.;

    Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)02172-0

doi: 10.1016/j.jaci.2007.10.043

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 116-121.e11 , January 2008

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