The Journal of Allergy and Clinical Immunology
Volume 120, Issue 6 , Pages 1292-1300 , December 2007

IL-13 involvement in eosinophilic esophagitis: Transcriptome analysis and reversibility with glucocorticoids

  • Carine Blanchard, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Melissa K. Mingler, MS

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Maria Vicario, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • Digestive Diseases Research Unit, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universtat Autònoma de Barcelona, Barcelona, Spain
    • ,
  • J. Pablo Abonia, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Yi Ying Wu, MS

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Thomas X. Lu, BS

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Margaret H. Collins, MD

      Affiliations

    • Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital and Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Philip E. Putnam, MD

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital and Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Susanne I. Wells, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Marc E. Rothenberg, MD, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • Corresponding Author InformationReprint requests: Marc Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML 7028, Cincinnati, Ohio 45229.

Received 3 October 2007 ,Revised 12 October 2007 ,Accepted 15 October 2007.

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 Supported in part by National Institutes of Health grants AI070235 and AI45898 (M.E.R.), the Food Allergy and Anaphylaxis Network (M.E.R.), the Campaign Urging Research for Eosinophil Disorders, the Buckeye Foundation (M.E.R.), the Food Allergy Project (M.E.R.), the American Heart Association 0625296B (C.B.), the Thrasher Research Funds NR-0014 (C.B.), the Instituto Carlos III Fondo de Investigación Sanitaria CD05/00060 (M.V.), Public Health Service grant CA102357 (S.I.W.), the Translational Research Initiative, Cincinnati Children's Hospital Medical Center, and the DHC (NIDDK 064403).

 Disclosure of potential conflict of interest: M. E. Rothenberg has consulting arrangements with Ception Therapeutics and Merck, owns stock in Ception Therapeutics, and is on the speakers' bureau for Merck. The rest of the authors have declared that they have no conflict of interest.

 Transcript profiling is available online at http://cypher.cchmc.org:1104. The reader should login as a guest and select “HG-U133 genome”; experiments and gene lists are located in the folder named MRothenberg/blanchard et al.

PII: S0091-6749(07)01974-4

doi: 10.1016/j.jaci.2007.10.024

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 6 , Pages 1292-1300 , December 2007

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