The Journal of Allergy and Clinical Immunology
Volume 121, Issue 2 , Pages 348-354 , February 2008

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma

  • Joanna S. Makowska, MD, PhD

      Affiliations

    • Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
    • ,
  • Janina Grzegorczyk, PhD

      Affiliations

    • Department of Immunological Diagnostics, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
    • ,
  • Barbara Bienkiewicz, MD, PhD

      Affiliations

    • Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
    • ,
  • Maria Wozniak, MD, PhD

      Affiliations

    • Allergy Clinic, Plock, Poland
    • ,
  • Marek L. Kowalski, MD, PhD

      Affiliations

    • Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
    • Corresponding Author InformationReprint requests: Marek L. Kowalski, MD, PhD, Department of Immunology, Rheumatology and Allergy, Chair of Immunology, Medical University of Lodz, 251 Pomorska Str, 92-215 Lodz, Poland.

Received 28 March 2007 ,Revised 16 September 2007 ,Accepted 26 September 2007.

  • Image Result

    Blood for flow cytometry and cytokine analysis was collected at the following time points: P0, before placebo inhalation; P1, 1 hour after completion of placebo administration; P20 = A0, 20 hours afte

    Blood for flow cytometry and cytokine analysis was collected at the following time points: P0, before placebo inhalation; P1, 1 hour after completion of placebo administration; P20 = A0, 20 hours after placebo administration (the baseline for aspirin challenge); A1, 1 hour after aspirin-induced reaction (in patients with positive reaction) or 1 hour after completion of aspirin administration (in patients with negative challenge); A20, 20 hours after reaction caused by aspirin (in patients with positive reaction) or 1 hour after completion of aspirin administration (in patients with negative challenge).

  • Image Result
    The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with negative and positive reaction (∗P < .05, ∗∗P < .005

    The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with negative and positive reaction (∗P < .05, ∗∗P < .005 compared with A0).

  • Image Result
    The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with isolated bronchial reactions, systemic reactions, an

    The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with isolated bronchial reactions, systemic reactions, and negative response (∗P < .05; ∗∗P < .005 compared with A0).

  • Image Result
    Serum concentrations of eotaxin 2 after bronchial challenge with lysine-aspirin in patients with positive and negative response (∗P < .05 compared with A0).

    Serum concentrations of eotaxin 2 after bronchial challenge with lysine-aspirin in patients with positive and negative response (∗P < .05 compared with A0).

 Supported by research grant #3PO5A12325 from the National Research Committee.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01833-7

doi: 10.1016/j.jaci.2007.09.039

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 2 , Pages 348-354 , February 2008

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