The Journal of Allergy and Clinical Immunology
Volume 120, Issue 6 , Pages 1301-1307 , December 2007

Augmented epithelial endothelin-1 expression in refractory asthma

  • Sophie Pégorier, PhD

      Affiliations

    • Inserm U700, Paris, and Université Paris 7, Faculté de Médecine Denis Diderot, site Xavier Bichat, Paris, France
    • ,
  • Nassim Arouche, MSc

      Affiliations

    • Inserm U700, Paris, and Université Paris 7, Faculté de Médecine Denis Diderot, site Xavier Bichat, Paris, France
    • ,
  • Marie-Christine Dombret, MD

      Affiliations

    • Département de Pneumologie A, Centre Hospitalier Universitaire Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris, France
    • ,
  • Michel Aubier, MD

      Affiliations

    • Inserm U700, Paris, and Université Paris 7, Faculté de Médecine Denis Diderot, site Xavier Bichat, Paris, France
    • Département de Pneumologie A, Centre Hospitalier Universitaire Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris, France
    • ,
  • Marina Pretolani, PhD

      Affiliations

    • Inserm U700, Paris, and Université Paris 7, Faculté de Médecine Denis Diderot, site Xavier Bichat, Paris, France
    • Corresponding Author InformationReprint requests: Marina Pretolani, PhD, Inserm Unité 700, Université Paris 7, Faculté de Médecine Denis Diderot, site Xavier Bichat, 16, rue Henri Huchard, 75018 Paris (France).

Received 12 April 2007 ,Revised 12 September 2007 ,Accepted 17 September 2007.

References 

  1. Proceeding of the ATS workshop on refractory asthma. Am J Respir Crit Care Med. 2000;162:2341–2351
  2. Bousquet J, Jeffery P, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000;161:1720–1745
  3. Wenzel SE. Severe asthma in adults. Am J Respir Crit Care Med. 2005;172:149–160
  4. Cundall M, Sun Y, Miranda C, Trudeau JB, Barnes S, Wenzel SE. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol. 2003;112:1064–1071
  5. Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, et al. Airway remodelling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol. 2003;111:1293–1298
  6. Pepe C, Foley S, Shannon J, Lemiere C, Olivenstein R, Ernst P, et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol. 2005;116:544–549
  7. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med. 2003;167:1360–1368
  8. Knight DA, Lane CL, Stick SM. Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?. Curr Opin Pharmacol. 2004;4:251–256
  9. Minshall E, Chakir J, Laviolette M, Molet S, Zhu Z, Olivenstein R, et al. IL-11 expression is increased in severe asthma: association with epithelial cells and eosinophils. J Allergy Clin Immunol. 2000;105:232–238
  10. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 2000;14:1362–1374
  11. Polosa R, Puddicombe SM, Krishna MT, Tuck AB, Howarth PH, Holgate ST, et al. Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. J Allergy Clin Immunol. 2002;109:75–81
  12. Hamilton LM, Torres-Lozano C, Puddicombe SM, Richter A, Kimber I, Dearman RJ, et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin Exp Allergy. 2003;33:233–240
  13. Puddicombe SM, Torres-Lozano C, Richter A, Bucchier F, Lordan JL, Howarth PH, et al. Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium. Am J Respir Cell Mol Biol. 2003;28:61–68
  14. Govindaraju V, Michoud MC, Al-Chalabi M, Ferraro P, Powell WS, Martin JG. Interleukin-8: novel roles in airway smooth muscle cell contraction and migration. Am J Physiol Cell Physiol. 2006;291:C957–C965
  15. Smith RE, Strieter RM, Zhang K, Phan SH, Standiford TJ, Lukacs NW, et al. A role for C-C chemokines in fibrotic lung disease. J Leukoc Biol. 1995;57:782–787
  16. Vignola AM, Chiappara G, Chanez P, Merendino AM, Pace E, Spatafora M, et al. Growth factors in asthma. Monaldi Arch Chest Dis. 1997;52:159–169
  17. Goldie RG. Potential role of the endothelins in airway remodelling in asthma. Pulm Pharmacol Ther. 1999;12:79–80
  18. Gueders MM, Foidart JM, Noel A, Cataldo DD. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol. 2006;533:133–144
  19. Guidelines for the Diagnosis and Management of Asthma. Expert Panel Report 2. Atlanta (GA): National Institute of Health; National Heart, Lung and Blood Institute; 1997;Publication no. 97-4051A
  20. Summary and recommendations of a workshop on the investigative use of fiberoptic bronchoscopy and bronchoalveolar lavage in asthmatics. Am Rev Respir Dis. 1985;132:180–182
  21. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:1–11
  22. Amin K, Ludviksdottir D, Janson C, Nettelbladt O, Björnsson E, Roomans GM, et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. Am J Respir Crit Care Med. 2000;162:2295–2301
  23. Balzar S, Chu HW, Silkoff P, Cundall M, Trudeau JB, Strand M, et al. Increased TGF-beta2 in severe asthma with eosinophilia. J Allergy Clin Immunol. 2005;115:110–117
  24. Miotto D, Christodoulopoulos P, Olivenstein R, Taha R, Cameron L, Tsicopoulos A, et al. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. J Allergy Clin Immunol. 2001;107:664–670
  25. Mattoli S, Soloperto M, Marini M, Fasoli A. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J Allergy Clin Immunol. 1991;88:376–384
  26. Nocker RE, Schoonbrood DE, van de Graaf EA, Hack CE, Lutter R, Jansen HM, et al. Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol. 1996;109:183–191
  27. Minshall EM, Leung DYM, Martin RJ, Song YL, Cameron L, Ernst P, et al. Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol. 1997;17:326–333
  28. Vachier I, Bonnans C, Chavis C, Farce M, Godard P, Bousquet J, et al. Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. J Allergy Clin Immunol. 2005;115:55–160
  29. Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem. 2004;279:23098–23103
  30. Marini M, Carpi S, Bellini A, Patalano F, Mattoli S. Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells. Biochem Biophys Res Commun. 1996;220:896–899
  31. Dawes KE, Cambrey AD, Campa JS, Bishop JE, McAnulty RJ, Peacock AJ, et al. Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity. Int J Biochem Cell Biol. 1996;28:229–238
  32. Sun G, Stacey MA, Bellini A, Marini M, Mattoli S. Endothelin-1 induces bronchial myofibroblast differentiation. Peptides. 1997;18:1449–1451
  33. Glassberg MK, Ergul A, Wanner A, Puett D. Endothelin-1 promotes mitogenesis in airway smooth muscle cells. Am J Respir Cell Mol Biol. 1994;10:316–321
  34. Shahar I, Fireman E, Topilsky M, Grief J, Schwarz Y, Kivity S, et al. Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. Int J Immunopharmacol. 1999;21:759–775
  35. Zhang S, Smartt H, Holgate ST, Roche WR. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab Invest. 1999;79:395–405
  36. Ackerman V, Carpi S, Bellini A, Vassalli G, Marini M, Mattoli S. Constitutive expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by histamine and interleukin-1. J Allergy Clin Immunol. 1995;96:618–627
  37. Redington AE, Springall DR, Meng QR, Tuck AB, Holgate ST, Polak JM, et al. Immunoreactive endothelin in bronchial biopsy specimens: increased expression in asthma and modulation by corticosteroid therapy. J Allergy Clin Immunol. 1997;100:544–552
  38. Aubert JD, Juillerat-Jeanneret L, Leuenberger P. Expression of endothelin-1 in human broncho-epithelial and monocytic cell lines: influence of tumor necrosis factor-alpha and dexamethasone. Biochem Pharmacol. 1997;53:547–552
  39. Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354:697–708
  40. Ordonez C, Ferrando R, Hyde DM, Wong HH, Fahy JV. Epithelial desquamation in asthma. Artifact or pathology?. Am J Respir Crit Care Med. 2000;162:2324–2329
  41. Vignola AM, Chiappara G, Siena L, Bruno A, Gagliardo R, Merendino AM, et al. Proliferation and activation of bronchial epithelial cells in corticosteroid-dependent asthma. J Allergy Clin Immunol. 2001;108:738–746
  42. Walter N, Collard HR, King TE. Current perspectives on the treatment of idiopathic pulmonary fibrosis. Proc Am Thorac Soc. 2006;3:330–338
  43. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med. 2001;345:517–525

 Supported in part by the “Agence Nationale de la Recherche,” Paris, France (grant no. 0012405). Sophie Pégorier was funded by the “Chancellerie des Universités de Paris en Sorbonne,” Paris, France.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01780-0

doi: 10.1016/j.jaci.2007.09.023

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 6 , Pages 1301-1307 , December 2007

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