The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 129-134 , January 2008

Reduced diversity in the early fecal microbiota of infants with atopic eczema

  • Mei Wang, PhD

      Affiliations

    • Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    • ,
  • Caroline Karlsson, MSc

      Affiliations

    • Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    • ,
  • Crister Olsson, PhD

      Affiliations

    • Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    • ,
  • Ingegerd Adlerberth, MD, PhD

      Affiliations

    • Department of Clinical Bacteriology, Göteborg University, Göteborg, Sweden
    • ,
  • Agnes E. Wold, MD, PhD

      Affiliations

    • Department of Clinical Bacteriology, Göteborg University, Göteborg, Sweden
    • ,
  • David P. Strachan, MD, PhD

      Affiliations

    • Division of Community Health Sciences, St George's, University of London, London, United Kingdom
    • ,
  • Paolo M. Martricardi, MD

      Affiliations

    • Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    • ,
  • Nils Åberg, MD, PhD

      Affiliations

    • Department of Paediatrics, Göteborg University, Göteborg, Sweden
    • ,
  • Michael R. Perkin, MD, PhD

      Affiliations

    • Division of Community Health Sciences, St George's, University of London, London, United Kingdom
    • ,
  • Salvatore Tripodi, MD

      Affiliations

    • Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
    • ,
  • Anthony R. Coates, MD, PhD

      Affiliations

    • Medical Microbiology, Department of Cellular and Molecular Medicine, St George's, University of London, London, United Kingdom
    • ,
  • Bill Hesselmar, MD, PhD

      Affiliations

    • Department of Paediatrics, Göteborg University, Göteborg, Sweden
    • ,
  • Robert Saalman, MD, PhD

      Affiliations

    • Department of Paediatrics, Göteborg University, Göteborg, Sweden
    • ,
  • Göran Molin, PhD

      Affiliations

    • Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    • ,
  • Siv Ahrné, PhD

      Affiliations

    • Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    • Corresponding Author InformationReprint requests: Siv Ahrné, PhD, Applied Nutrition, PO Box 124, SE-22100 Lund, Sweden.

Received 4 June 2007 ,Revised 5 September 2007 ,Accepted 10 September 2007.

  • Image Result

    Median number of peaks and bands after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or

    Median number of peaks and bands after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or stayed healthy. For each group, median and 10th, 25th, 75th, and 90th percentiles are shown. ∗P < .05.

  • Image Result
    Shannon-Wiener index after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or stayed heal

    Shannon-Wiener index after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or stayed healthy. For each group, median and 10th, 25th, 75th, and 90th percentiles are shown. ∗For T-RFLP, P < .01 and for TTGE, P < .05.

  • Image Result
    Simpson index after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or stayed healthy. Fo

    Simpson index after T-RFLP of 16S rDNA with AluI for cutting and TTGE, respectively, generated from the fecal microbiota of 1-week-old infants that at 18 months had atopic eczema or stayed healthy. For each group, median and 10th, 25th, 75th, and 90th percentiles are shown. ∗P < .05.

 Supported by the European Framework Programme 5 (QLRT-2000-00538) and by an unrestricted grant from Probi AB, Lund, Sweden.

 Disclosure of potential conflict of interest: C. Olsson owns stock in Probi AB. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01767-8

doi: 10.1016/j.jaci.2007.09.011

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 129-134 , January 2008

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