The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 72-80.e3 , January 2008

Lung function, respiratory symptoms, and the menopausal transition

  • Francisco Gómez Real, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
    • Centre de Recerca en Epidemiologia Ambiental (CREAL)–Institut Municipal d'Investigació Mèdica (IMIM-IMAS), Barcelona, Spain
    • Respiratory Research Group, Institute of Medicine, University of Bergen, Bergen, Norway
    • Corresponding Author InformationReprint requests: Francisco Gómez Real, MD, Department of Gynecology and Obstetrics, Haukeland University Hospital, 5021 Bergen, Norway.
    • ,
  • Cecilie Svanes, MD, PhD

      Affiliations

    • Centre de Recerca en Epidemiologia Ambiental (CREAL)–Institut Municipal d'Investigació Mèdica (IMIM-IMAS), Barcelona, Spain
    • Respiratory Research Group, Institute of Medicine, University of Bergen, Bergen, Norway
    • Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    • ,
  • Ernst Reidar Omenaas, MD, PhD

      Affiliations

    • Respiratory Research Group, Institute of Medicine, University of Bergen, Bergen, Norway
    • Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    • Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
    • ,
  • Josep Maria Antò, MD, PhD

      Affiliations

    • Centre de Recerca en Epidemiologia Ambiental (CREAL)–Institut Municipal d'Investigació Mèdica (IMIM-IMAS), Barcelona, Spain
    • Departament de Ciencies Experimentals i de la Vida-Universitat Pompeu Fabra (UPF), Barcelona, Spain
    • ,
  • Estel Plana, MSc

      Affiliations

    • Centre de Recerca en Epidemiologia Ambiental (CREAL)–Institut Municipal d'Investigació Mèdica (IMIM-IMAS), Barcelona, Spain
    • Departament de Ciencies Experimentals i de la Vida-Universitat Pompeu Fabra (UPF), Barcelona, Spain
    • ,
  • Deborah Jarvis, MD

      Affiliations

    • Department of Public Health Sciences, Imperial College, London, United Kingdom
    • ,
  • Christer Janson, MD, PhD

      Affiliations

    • Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden
    • ,
  • Françoise Neukirch, MD, PhD

      Affiliations

    • Epidémiologie des Maladies Respiratoires, INSERM U700, Faculté de Médecine Xavier Bichat, Paris, France
    • ,
  • Elisabeth Zemp, MD, PhD

      Affiliations

    • Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    • ,
  • Julia Dratva, MD, PhD

      Affiliations

    • Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    • ,
  • Matthias Wjst, MD, PhD

      Affiliations

    • Molecular Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    • ,
  • Knut Svanes, MD, PhD

      Affiliations

    • Institute of Surgery, Haukeland University Hospital, Bergen, Norway
    • ,
  • Bénédicte Leynaert, MSc, PhD

      Affiliations

    • Epidémiologie des Maladies Respiratoires, INSERM U700, Faculté de Médecine Xavier Bichat, Paris, France
    • ,
  • Jordi Sunyer, MD, PhD

      Affiliations

    • Centre de Recerca en Epidemiologia Ambiental (CREAL)–Institut Municipal d'Investigació Mèdica (IMIM-IMAS), Barcelona, Spain
    • Departament de Ciencies Experimentals i de la Vida-Universitat Pompeu Fabra (UPF), Barcelona, Spain

Received 27 June 2007 ,Revised 23 August 2007 ,Accepted 27 August 2007.

References 

  1. Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax. 1999;54:1119–1138
  2. Real FG, Svanes C, Omenaas ER, Antò JM, Plana E, Janson C, et al. Menstrual irregularity and asthma and lung function. J Allergy Clin Immunol. 2007;120:557–564
  3. Salam MT, Wenten M, Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. J Allergy Clin Immunol. 2006;117:1001–1007
  4. Gómez Real F, Svanes C, Bjornsson EH, Franklin KA, Gislason D, Gislason T, et al. Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax. 2006;61:34–40
  5. Svanes C, Real FG, Gislason T, Jansson C, Jogi R, Norrman E, et al. Association of asthma and hay fever with irregular menstruation. Thorax. 2005;60:445–450
  6. Troisi RJ, Speizer FE, Willett WC, Trichopoulos D, Rosner B. Menopause, postmenopausal estrogen preparations, and the risk of adult-onset asthma. A prospective cohort study. Am J Respir Crit Care Med. 1995;152:1183–1188
  7. Speroff L, Glass RH, Kase NG. Anovulation and the polycystic ovary. In:  Mitchell C editors. Clinical gynecologic endocrinology and infertility. 6th ed.. Baltimore: Lippincott Williams & Wilkins; 1999;p. 487–522
  8. Livingstone C, Collison M. Sex steroids and insulin resistance. Clin Sci (Lond). 2002;102:151–166
  9. Bruning PF, Bonfrer JM. Possible relevance of steroid availability and breast cancer. Ann N Y Acad Sci. 1988;538:257–264
  10. Rannevik G, Jeppsson S, Johnell O, Bjerre B, Laurell-Borulf Y, Svanberg L. A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Maturitas. 1995;21:103–113
  11. Speroff L, Glass RH, Kase NG. Menopause and the Perimenopausal transition. In:  Mitchell C editors. Clinical gynecologic endocrinology and infertility. 6th ed.. Baltimore: Lippincott Williams & Wilkins; 1999;p. 643–724
  12. Speroff L, Glass RH, Kase NG. Amenorrhea. In:  Mitchell C editors. Clinical gynecologic endocrinology and infertility. 6th ed.. Baltimore: Lippincott Williams & Wilkins; 1999;p. 421–485
  13. Hu P, Greendale GA, Palla SL, Reboussin BA, Herrington DM, Barrett-Connor E, et al. The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: the postmenopausal estrogen progestin intervention (PEPI) trial. Atherosclerosis. 2006;185:347–352
  14. Stopinska-Gluszak U, Waligora J, Grzela T, Gluszak M, Jozwiak J, Radomski D, et al. Effect of estrogen/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal women. J Reprod Immunol. 2006;69:65–75
  15. Simpson ER, Misso M, Hewitt KN, Hill RA, Boon WC, Jones ME, et al. Estrogen—the good, the bad, and the unexpected. Endocr Rev. 2005;26:322–330
  16. Lindheim SR, Presser SC, Ditkoff EC, Vijod MA, Stanczyk FZ, Lobo RA. A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil Steril. 1993;60:664–667
  17. Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003;86:225–230
  18. Simpson ER, Clyne C, Speed C, Rubin G, Bulun S. Tissue-specific estrogen biosynthesis and metabolism. Ann N Y Acad Sci. 2001;949:58–67
  19. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003;88:2404–2411
  20. Kuh D, Langenberg C, Hardy R, Kok H, Cooper R, Butterworth S, et al. Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study. BJOG. 2005;112:476–485
  21. Balzano G, Fuschillo S, Melillo G, Bonini S. Asthma and sex hormones. Allergy. 2001;56:13–20
  22. Jarvis D, Burney P, Chinn S, Luczynska C, Anto JM, Cerveri I, et al. The European Community Respiratory Health Survey II. Eur Respir J. 2002;20:1071–1079
  23. Burney PG, Luczynska C, Chinn S, Jarvis D. The European Community Respiratory Health Survey. Eur Respir J. 1994;7:954–960
  24. Brambilla DJ, McKinlay SM, Johannes CB. Defining the perimenopause for application in epidemiologic investigations. Am J Epidemiol. 1994;140:1091–1095
  25. Pekkanen J, Sunyer J, Anto JM, Burney P. Operational definitions of asthma in studies on its aetiology. Eur Respir J. 2005;26:28–35
  26. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163:1256–1276
  27. Chinn S, Jarvis D, Melotti R, Luczynska C, Ackermann-Liebrich U, Anto JM, et al. Smoking cessation, lung function, and weight gain: a follow-up study. Lancet. 2005;365:1629–1635discussion 1600-1601
  28. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  29. Hastie T, Tibshirani R. Generalized additive models for medical research. Stat Methods Med Res. 1995;4:187–196
  30. Randolph JF, Crawford S, Dennerstein L, Cain K, Harlow SD, Little R, et al. The value of follicle-stimulating hormone concentration and clinical findings as markers of the late menopausal transition. J Clin Endocrinol Metab. 2006;91:3034–3040
  31. Grodstein F, Clarkson TB, Manson JE. Understanding the divergent data on postmenopausal hormone therapy. N Engl J Med. 2003;348:645–650
  32. Cooper GS, Sandler DP, Bohlig M. Active and passive smoking and the occurrence of natural menopause. Epidemiology. 1999;10:771–773
  33. Baron JA, La Vecchia C, Levi F. The antiestrogenic effect of cigarette smoking in women. Am J Obstet Gynecol. 1990;162:502–514
  34. Key TJ, Pike MC, Brown JB, Hermon C, Allen DS, Wang DY. Cigarette smoking and urinary oestrogen excretion in premenopausal and post-menopausal women. Br J Cancer. 1996;74:1313–1316
  35. Lange P, Groth S, Kastrup J, Mortensen J, Appleyard M, Nyboe J, et al. Diabetes mellitus, plasma glucose and lung function in a cross-sectional population study. Eur Respir J. 1989;2:14–19
  36. Engstrom G, Hedblad B, Nilsson P, Wollmer P, Berglund G, Janzon L. Lung function, insulin resistance and incidence of cardiovascular disease: a longitudinal cohort study. J Intern Med. 2003;253:574–581
  37. Lazarus R, Sparrow D, Weiss ST. Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study. Eur Respir J. 1998;12:641–645
  38. Lawlor DA, Ebrahim S, Smith GD. Associations of measures of lung function with insulin resistance and Type 2 diabetes: findings from the British Women's Heart and Health Study. Diabetologia. 2004;47:195–203
  39. Davis WA, Knuiman M, Kendall P, Grange V, Davis TM. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Care. 2004;27:752–757
  40. Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation. 2004;110:1564–1571
  41. Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 2004;25:4–7
  42. Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev. 2003;24:278–301
  43. Kalish GM, Barrett-Connor E, Laughlin GA, Gulanski BI. Association of endogenous sex hormones and insulin resistance among postmenopausal women: results from the Postmenopausal Estrogen/Progestin Intervention Trial. J Clin Endocrinol Metab. 2003;88:1646–1652
  44. Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, et al. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol. 2004;150:161–171

 F.G.R. was supported exclusively by the Norwegian Research Council (grant NFR 161299/V50). European Community Respiratory Health Survey (ECRHS) II was supported by the European Commission, as part of their Quality of Life program. Bodies funding the local studies in ECRHS II are listed in Appendix 1 in the Online Repository at www.jacionline.org. The European Commission supported the transports of serum for hormones measurement to Paris. Hormones measures were funded by the local budget of the ECRHS Paris team, INSERM U700, Epidemiology, with further support from the Comité National contre les Maladies Respiratoires (CNMR) and the Centre d'Investigation Clinique (CIC), Bichat Hospital.

 Disclosure of potential conflict of interest: E. R. Omenaas has received grant support from the Norwegian Research Council. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01658-2

doi: 10.1016/j.jaci.2007.08.057

The Journal of Allergy and Clinical Immunology
Volume 121, Issue 1 , Pages 72-80.e3 , January 2008

Article Tools

* Image Usage & Resolution