The Journal of Allergy and Clinical Immunology
Volume 120, Issue 5 , Pages 1172-1177 , November 2007

The natural history of IgE-mediated cow's milk allergy

Received 21 May 2007 ,Revised 8 August 2007 ,Accepted 8 August 2007.

References 

  1. Bock SA. Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life. Pediatrics. 1987;79:683–688
  2. Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, Kuitunen P, Lope L, Renlund M, et al. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol. 1999;104:457–461
  3. Schrander JJ, van den Bogart JP, Forget PP, Schrander-Stumpel CT, Kuijten RH, Kester AD. Cow's milk protein intolerance in infants under 1 year of age: a prospective epidemiological study. Eur J Pediatr. 1993;152:640–644
  4. Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life: clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy. 1990;45:587–596
  5. Hill DJ, Firer MA, Ball G, Hosking CS. Natural history of cows' milk allergy in children: immunological outcome over 2 years. Clin Exp Allergy. 1993;23:124–131
  6. Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. J Allergy Clin Immunol. 2005;116:869–875
  7. Bishop JM, Hill DJ, Hosking CS. Natural history of cow milk allergy: clinical outcome. J Pediatr. 1990;116:862–867
  8. Hill DJ, Davidson GP, Cameron DJ, Barnes GL. The spectrum of cow's milk allergy in childhood. Clinical, gastroenterological and immunological studies. Acta Paediatr Scand. 1979;68:847–852
  9. Perry TT, Matsui EC, Kay Conover-Walker M, Wood RA. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol. 2004;114:144–149
  10. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107:891–896
  11. Shek LP, Soderstrom L, Ahlstedt S, Beyer K, Sampson HA. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. J Allergy Clin Immunol. 2004;114:387–391
  12. Vanto T, Helppila S, Juntunen-Backman K, Kalimo K, Klemola T, Korpela R, et al. Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. J Pediatr. 2004;144:218–222

 Supported by National Institutes of Health Training Grant #5T32 AI07007 and the Eudowood Foundation.

 Disclosure of potential conflict of interest: R. A. Wood has consulting arrangements with Dey Pharmaceutical, has received grant support from Merck and Genentech, and is on the speakers' bureau for Dey, Merck, and Glaxo. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01589-8

doi: 10.1016/j.jaci.2007.08.023

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 5 , Pages 1172-1177 , November 2007