The natural history of IgE-mediated cow's milk allergy

CMA resolution over time. Kaplan-Meier survival curves for development of tolerance to cow's milk over time using 3 definitions for tolerance. The black line is the survival curve for criteria 1, the red line is the survival curve for criteria 2, and the blue line is the survival curve for criteria 3.

Trend in cm-IgE levels over time by final CMA status. Scatter plots of all cm-IgE levels recorded, by age, to age 18 years (n = 2498). A, All values in the group with persistent CMA (n = 1651). B, All values in the group with resolved CMA (n = 847). Nonparametric smoothed curves show the trend in cm-IgE levels over time. These curves approximate the mean value at any given age.

Relationship of peak cm-IgE level to resolution of IgE-mediated CMA over the period of the first 18 years of life. Patients were stratified by peak cm-IgE level, and survival curves for each stratum of peak cm-IgE level were plotted. The number of patients in each stratum was as follows: <2 kU/L (n = 162); 2-4.9 (n = 106); 5-9.9 (n = 85); 10-19.9 (n = 115); 20-49.9 (n = 107); 50+ (n = 229).