The Journal of Allergy and Clinical Immunology
Volume 120, Issue 5 , Pages 1139-1145 , November 2007

Asthma cases attributable to atopy: Results from the Third National Health and Nutrition Examination Survey

  • Samuel J. Arbes Jr., DDS, MPH, PhD

      Affiliations

    • Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC
  • ,
  • Peter J. Gergen, MD, MPH

      Affiliations

    • Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
  • ,
  • Ben Vaughn, MS

      Affiliations

    • Rho, Inc, Chapel Hill, NC
  • ,
  • Darryl C. Zeldin, MD

      Affiliations

    • Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC
    • Corresponding Author InformationReprint requests: Darryl C. Zeldin, MD, NIEHS/NIH, PO Box 12233, MD D2-01, Research Triangle Park, NC 27709.

Received 4 May 2007 ,Revised 18 July 2007 ,Accepted 20 July 2007.

References 

  1. Arshad SH, Tariq SM, Matthews S, Hakim E. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics. 2001;108:E33
  2. Gergen PJ, Turkeltaub PC. The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II). J Allergy Clin Immunol. 1992;90:579–588
  3. Squillace SP, Sporik RB, Rakes G, Couture N, Lawrence A, Merriam S, et al. Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia: multiple regression analysis of a population-based study. Am J Respir Crit Care Med. 1997;156:1760–1764
  4. Lanphear BP, Kahn RS, Berger O, Auinger P, Bortnick SM, Nahhas RW. Contribution of residential exposures to asthma in US children and adolescents. Pediatrics. 2001;107:E98
  5. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood: a prospective study. N Engl J Med. 1990;323:502–507
  6. Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von Mutius E, et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet. 2000;356:1392–1397
  7. Pearce N, Pekkanen J, Beasley R. How much asthma is really attributable to atopy?. Thorax. 1999;54:268–272
  8. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med. 1989;320:271–277
  9. Arbes SJ, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol. 2005;116:377–383
  10. National Center for Health Statistics (U.S.) . Public use data tape documentation: allergy skin testing: tape number 5309: National Health and Nutrition Examination Survey, 1976-80. Hyattsville (MD): US Department of Health and Human Services, Public Health Service, National Center for Health Statistics; 1986;
  11. Miettinen OS. Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol. 1974;99:325–332
  12. Judkins DR. Fay's method for variance estimation. J Official Stat. 1990;6:223–239
  13. Jaakkola MS, Ieromnimon A, Jaakkola JJ. Are atopy and specific IgE to mites and molds important for adult asthma?. J Allergy Clin Immunol. 2006;117:642–648
  14. Ponsonby AL, Gatenby P, Glasgow N, Mullins R, McDonald T, Hurwitz M. Which clinical subgroups within the spectrum of child asthma are attributable to atopy?. Chest. 2002;121:135–142
  15. Sunyer J, Jarvis D, Pekkanen J, Chinn S, Janson C, Leynaert B, et al. Geographic variations in the effect of atopy on asthma in the European Community Respiratory Health Study. J Allergy Clin Immunol. 2004;114:1033–1039
  16. Arbes SJ, Cohn RD, Yin M, Muilenberg ML, Friedman W, Zeldin DC. Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: results from the National Survey of Lead and Allergens in Housing. J Allergy Clin Immunol. 2004;114:111–117
  17. Cohn RD, Arbes SJ, Jaramillo R, Reid LH, Zeldin DC. National prevalence and exposure risk for cockroach allergen in U.S. households. Environ Health Perspect. 2006;114:522–526
  18. von Mutius E. Asthma and allergies in rural areas of Europe. Proc Am Thorac Soc. 2007;4:212–216
  19. Sood A, Ford ES, Camargo CA. Association between leptin and asthma in adults. Thorax. 2006;61:300–305
  20. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma,and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet. 2001;357:752–756
  21. Plaschke P, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B. Association between atopic sensitization and asthma and bronchial hyperresponsiveness in Swedish adults: pets, and not mites, are the most important allergens. J Allergy Clin Immunol. 1999;104:58–65
  22. Rothman KJ. Modern epidemiology. 1st ed.. Boston: Little Brown; 1986;

 Supported by the Intramural Research Programs of the National Institute of Environmental Health Sciences and the National Institute of Allergy and Infectious Diseases, the National Institutes of Health.

 Disclosure of potential conflict of interest: B. Vaughn is employed by Rho, Inc. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01460-1

doi: 10.1016/j.jaci.2007.07.056

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 5 , Pages 1139-1145 , November 2007