The Journal of Allergy and Clinical Immunology
Volume 120, Issue 2 , Pages 247-254 , August 2007

TH17 cells in the big picture of immunology

Received 18 May 2007 ,Revised 25 June 2007 ,Accepted 29 June 2007.

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    Schematic overview of T-cell phenotypes in allergic disease. TH1, TH2, TH17, and Treg cells are characterized by cytokines, which mediate specific functions in different tissue cells such as dendritic

    Schematic overview of T-cell phenotypes in allergic disease. TH1, TH2, TH17, and Treg cells are characterized by cytokines, which mediate specific functions in different tissue cells such as dendritic cells (Dc), keratinocytes (Ker), epithelial cells (Epit), eosinophils (Eos), mast cells (Mas), fibroblasts (Fib), and neutrophils (Neut). Myofib., Myofibroblast.

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    Positive feedback loops in transcription factors during T-cell differentiation. During naive T-cell differentiation to TH1, TH17, Treg, and TH2 cells, IFN-γ, IL-6, TGF-β, and IL-4 produced by these ce

    Positive feedback loops in transcription factors during T-cell differentiation. During naive T-cell differentiation to TH1, TH17, Treg, and TH2 cells, IFN-γ, IL-6, TGF-β, and IL-4 produced by these cells further induce the synthesis of transcription factors T-bet, RORγt, FOXP3, and GATA-3, respectively. Epit, Epithelial cells; Fib, fibroblasts.

 Supported by Swiss National Science Foundation grants 310000-112329, 3200B0-105865, 32600-113165, and 32000-112306; the Bonizzi-Theler Foundation Zurich; the Swiss Life Foundation Zurich; and the Global Allergy and Asthma European Network.Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(07)01263-8

doi: 10.1016/j.jaci.2007.06.039

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 2 , Pages 247-254 , August 2007

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