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The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1
, Pages 84-90
, July 2007
Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
References
- Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258–2261
- Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci U S A. 1993;90:3735–3739
- . Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol. 2005;174:1063–1072
- Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003;9:582–588
- Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 1993;90:3730–3734
- Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax. 2006;61:202–208
- Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma. Chest. 2005;128:1921–1927
- . Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population. J Immunol. 1997;159:4506–4513
- . Interleukin-4 and interleukin-13 signaling connections maps. Science. 2003;300:1527–1528
- Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem. 1996;271:16921–16926
- . IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med. 2006;12:99–106
- Genetic susceptibility to asthma–bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995;333:894–900
- A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet. 1997;15:389–392
- . The genetics of asthma: mapping genes for complex traits in founder populations. Clin Exp Allergy. 1998;28(suppl 1):101–105discussion 8-10
- Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics. 1994;23:464–470
- . Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin Exp Allergy. 1995;25(suppl 2):84–88discussion 95-6
- . Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med. 2005;172:446–452
- Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation. J Immunol. 2006;177:8633–8642
- . IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest. 2005;115:747–754
- Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol. 2002;109:980–987
- Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet. 2000;9:549–559
- Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol. 2001;25:377–384
- Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland. Am J Respir Crit Care Med. 2001;164:2036–2044
- Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy. 2002;32:387–390
- A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol. 2000;105:506–513
- Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002;23:335–348
- IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol. 2006;117:269–274
- Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol. 2006;117:1306–1313
- . A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy. 2001;31:1515–1521
- Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol. 2007;119:654–661
- . Collaborative studies on the genetics of asthma: National Heart, Lung and Blood Institute. Clin Exp Allergy. 1995;25(suppl 2):29–32
- Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med. 1995;152:1107–1136
- . A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects. Am Rev Respir Dis. 1982;126:235–240
- The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials. 1999;20:91–120
- Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med. 2000;343:1054–1063
- . Detection of specific polymerase chain reaction product by utilizing the 5′—3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A. 1991;88:7276–7280
- . PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet. 1998;63:259–266
- . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
- An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun. 1999;1:61–65
- Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. Genet Med. 2005;7:406–410
- Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. Genes Immun. 2003;4:385–389
- . PBAT: tools for family-based association studies. Am J Hum Genet. 2004;74:367–369
- Freely associating. Nat Genet. 1999;22:1–2
- . Viruses as precipitants of asthmatic attacks in children. JAMA. 1974;227:292–298
- A study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospitalization in children. Thorax. 2006;61:376–382
- Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol. 2006;117:72–78
- IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect. 2006;8:2880–2889
- Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction. J Allergy Clin Immunol. 2002;110:607–609
- . Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J Infect Dis. 2006;193:438–441
- . IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. J Allergy Clin Immunol. 2007;119:1086–1091
- Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13. J Allergy Clin Immunol. 2003;111:1049–1061
- The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion. J Clin Immunol. 2005;25:437–444
Supported by grants HL04370 and HL66289 from the National Institutes of Health. The CAMP Genetics Ancillary Study is supported by the National Heart, Lung, and Blood Institute, N01-HR-16049. Additional support for this research came from grants P50 HL67664 and T32 HL07427 from the National Institutes of Health and the National Heart, Lung, and Blood Institute.Disclosure of potential conflict of interest: E. K. Silverman has consulting arrangements with GlaxoSmithKline; has received grant support from GlaxoSmithKline; has received money for a talk on chronic obstructive pulmonary disease genetics from Wyeth; and has received honoraria from Bayer. The rest of the authors have declared that they have no conflict of interest.
PII: S0091-6749(07)00858-5
doi: 10.1016/j.jaci.2007.04.032
© 2007 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1
, Pages 84-90
, July 2007
