About the cover

Article Outline

 
• 
  • View Large Image
  • Download to PowerPoint

The cover image shows an eosinophilic microabscess located in the esophageal epithelium of a patient with eosinophilic esophagitis. Note the surrounding tissue damage. Several articles in this month's issue examine the important role of eosinophils. A good place to start would be the Editorial by Rothenberg (p 1321), which provides an overview of the latest concepts about eosinophils as summarized in this issue of the Journal.

In the Current Reviews article, Dagmar and Hans-Uwe Simon (p 1291) present a clinically relevant classification of eosinophilic disorders based on new understandings of the disease mechanism. The Molecular Mechanisms review by Rosenberg et al (p 1303) summarizes recent advances in understanding eosinophil development and accumulation in inflamed tissues. In a Current Perspectives review, Jacobsen et al (p 1313) propose that eosinophils are critical immunoregulatory cells with pleotropic capabilities that affect diverse immune responses. In an Update Review, Munitz and Levi-Schaffer (p 1382) review the biology and therapeutic significance of a new set of inhibitory receptors expressed by eosinophils. Finally, in the Images in Allergy and Immunology feature, Foley and colleagues (p 1563) review the role of eosinophils in diverse tissue remodeling responses. Overall, we are now in a very strong position to design ways to modulate the activity of eosinophils in a variety of immune responses, opening the door to new approaches for therapeutic intervention in allergic disease. Articles relevant to the theme of “Eosinophil-mediated disease” are noted in the Table of Contents by a red starburst next to their titles.

Original image supplied by Dr Margaret Collins, Cincinnati Children's Hospital Medical Center. Adapted for the cover by JDI, LLC.