The Journal of Allergy and Clinical Immunology
Volume 119, Issue 6 , Pages 1511-1513, June 2007

Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis

  • Sergio Romagnani, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Sergio Romagnani, MD, Department of Internal Medicine, viale Morgagni 85, Firenze 50134, Italy.

From the Department of Internal Medicine, University of Florence

Received 5 April 2007; accepted 6 April 2007.

Florence, Italy

Key words: Hygiene hypothesis, TLR, pathogen-associated molecular pattern, Delta-4, Jagged-1, Notch, IL-12, TH1, TH2, immune deviation

Abbreviations used: ALEX, Allergy and Endotoxin, DC, Dendritic cell, TLR, Toll-like receptor

No abstract is available. To read the body of this article, please view the Full Text online.

 

 Disclosure of potential conflict of interest: The author has declared that he has no conflict of interest.

PII: S0091-6749(07)00756-7

doi:10.1016/j.jaci.2007.04.005

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 6 , Pages 1511-1513, June 2007

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