The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1 , Pages 200-206 , July 2007

Protein kinase Cζ: A novel protective neonatal T-cell marker that can be upregulated by allergy prevention strategies

  • Susan L. Prescott, MBBS, PhD, FRACP

      Affiliations

    • From the School of Pediatrics and Child Health, University of Western Australia, Perth
    • Corresponding Author InformationReprint requests: Susan L. Prescott, MBBS, PhD, FRACP, School of Pediatrics and Child Health, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia.
    • ,
  • James Irvine, BSc(Hons)

      Affiliations

    • Department of Immunopathology, Women and Children's Hospital, Adelaide, and the Department of Pediatrics, University of Adelaide, Australia
    • ,
  • Janet A. Dunstan, BAppSc, PhD

      Affiliations

    • From the School of Pediatrics and Child Health, University of Western Australia, Perth
    • ,
  • Charles Hii, BSc(Hons), PhD

      Affiliations

    • Department of Immunopathology, Women and Children's Hospital, Adelaide, and the Department of Pediatrics, University of Adelaide, Australia
    • ,
  • Antonio Ferrante, PhD, FRCPath

      Affiliations

    • Department of Immunopathology, Women and Children's Hospital, Adelaide, and the Department of Pediatrics, University of Adelaide, Australia

Received 15 December 2006 ,Revised 9 March 2007 ,Accepted 13 March 2007.

References 

  1. Tang MLK, Kemp AS, Thorburn J, Hill D. Reduced interferon gamma secretion in neonates and subsequent atopy. Lancet. 1994;344:983–985
  2. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema?. Clin Exp Allergy. 1994;24:423–430
  3. Martinez F, Stern D, Wright A, Holberg C, Taussig L, Halonen M. Association of interleukin-2 and interferon-g production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy. J Allergy Clin Immunol. 1995;96:652–660
  4. Kondo N, Kobayashi Y, Shinoda S, Takenaka R, Teramoto T, Kaneko H, et al. Reduced interferon gamma production by antigen-stimulated cord blood mononuclear cells is a risk factor of allergic disorders: 6-year follow-up study. Clin Exp Allergy. 1998;28:1340–1344
  5. Prescott S, Macaubas C, Smallacombe T, Holt B, Sly P, Loh R, et al. Development of allergen-specific T-cell memory in atopic and normal children. Lancet. 1999;353:196–200
  6. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Loh R, et al. Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants. Clin Exp Allergy. 1998;28(suppl 5):39–44discussion 50-1
  7. Odelram H, Björkstén B, Leander E, Kjellman N. Predictors of atopy in newborn babies. Allergy. 1995;50:585–592
  8. Matsuoka T, Matsubara T, Katayama K, Takeda K, Koga M, Furukawa S. Increase of cord blood cytokine-producing T cells in intrauterine infection. Pediatr Int. 2001;43:453–457
  9. Dunstan J, Mori TA, Barden A, Beilin LJ, Taylor A, Holt PG, et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomised controlled trial. J Allergy Clin Immunol. 2003;112:1178–1184
  10. Devereux G, Barker RN, Seaton A. Antenatal determinants of neonatal immune responses to allergens. Clin Exp Allergy. 2002;32:43–50
  11. Noakes PS, Holt PG, Prescott SL. Maternal smoking in pregnancy alters neonatal cytokine responses. Allergy. 2003;58:1053–1058
  12. Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, et al. Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy. Clin Exp Allergy. 2003;33:442–448
  13. Hii CS, Costabile M, Mayne GC, Der CJ, Murray AW, Ferrante A. Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells. Biochem J. 2003;370:497–503
  14. Egerton M, Fitzpatrick DR, Kelso A. Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes. Int Immunol. 1998;10:223–229
  15. Rincon M, Flavell RA, Davis RA. The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. Free Radic Biol Med. 2000;28:1328–1337
  16. Li YQ, Hii CS, Der CJ, Ferrante A. Direct evidence that ERK regulates the production/secretion of interleukin-2 in PHA/PMA-stimulated T lymphocytes. Immunology. 1999;96:524–528
  17. Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD, et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. 2000;71:1085–1094
  18. Dunstan JA, Mori TA, Barden A, Beilin LJ, Holt PG, Calder PC, et al. Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. Eur J Clin Nutr. 2004;58:429–437
  19. Rowe J, Macaubas C, Monger T, Holt BJ, Harvey J, Poolman JT, et al. Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine- specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic th1 function. J Infect Dis. 2001;184:80–88
  20. Hanifen J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh). 1980;92(suppl 144):44–47
  21. Hide DW, Arshad SH, Twiselton R, Stevens M. Cord serum IgE: an insensitive method for prediction of atopy. Clin Exp Allergy. 1991;21:739–743
  22. Bergmann RL, Edenharter G, Bergmann KE, Guggenmoos-Holzmann I, Forster J, Bauer CP, et al. Predictability of early atopy by cord blood IgE and parental history. Clin Exp Allergy. 1997;27:752–760
  23. Hansen LG, Halken S, Host A, Møller K, Østerballe O. Prediction of allergy from family history and cord blood IgE levels. Pediatr Allergy Immunol. 1993;4:34–40
  24. Croner S, Kjellman N-I. Predictors of atopic disease: cord blood IgE and month of birth. Allergy. 1986;41:68–70
  25. Upham JW, Holt PG, Taylor A, Thornton CA, Prescott SL. HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses. J Allergy Clin Immunol. 2004;114:1202–1208
  26. Börres MP, Björkstén B. Peripheral blood eosinophils and IL-4 in infancy in relation to the appearance of allergic disease during the first 6 years of life. Pediatr Allergy Immunol. 2004;15:216–220
  27. van der Velden VH, Laan MP, Baert MR, de Waal Malefyt R, Neijens HJ, Savelkoul HF. Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10. Clin Exp Allergy. 2001;31:997–1006
  28. Marks GB, Mihrshahi S, Kemp A, Tovey ER, Webb K, Almqvist C, et al. Prevention of asthma during the first 5 years of life: a randomised controlled trial. J Allergy Clin Immunol. 2006;118:53–61

 Supported by the National Health and Medical Research Council of Australia. J.A.D. is supported by the Child Health Research Foundation of Western Australia.Disclosure of potential conflict of interest: The authors have received grant support from the National Health and Medical Research Council of Australia.

PII: S0091-6749(07)00644-6

doi: 10.1016/j.jaci.2007.03.045

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1 , Pages 200-206 , July 2007

Article Tools

* Image Usage & Resolution