The Journal of Allergy and Clinical Immunology
Volume 120, Issue 2 , Pages 381-387 , August 2007

Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: Case-control study

  • Samantha Walker, PhD

      Affiliations

    • From Education for Health, Warwick
    • Allergy and Respiratory Research Group, Division of Community Health Sciences, General Practitioner Section, University of Edinburgh
    • Corresponding Author InformationReprint requests: Samantha Walker, PhD, Education for Health, 10 Church Street, Warwick, United Kingdom CV34 4AB.
  • ,
  • Saba Khan-Wasti, BSc

      Affiliations

    • From Education for Health, Warwick
  • ,
  • Monica Fletcher, MSc

      Affiliations

    • From Education for Health, Warwick
  • ,
  • Paul Cullinan, MD

      Affiliations

    • Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, London
  • ,
  • Jessica Harris, MSc

      Affiliations

    • Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, London
  • ,
  • Aziz Sheikh, MD

      Affiliations

    • From Education for Health, Warwick
    • Allergy and Respiratory Research Group, Division of Community Health Sciences, General Practitioner Section, University of Edinburgh

Received 2 November 2006 ,Revised 23 March 2007 ,Accepted 26 March 2007.

References 

  1. Strachan DP, Sibbald B, Weiland SK, Ait-Khaled N, Anabwani G, Anderson HR, et al. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Allergy Immunol. 1997;8:161–176
  2. Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child. 1989;64:1452–1456
  3. Frossard N, Melac M, Benabdesselam O, Pauli G. Consistency of the reactivity of cetirizine and ebastine on skin reactivity. Ann Allergy Asthma Immunol. 1998;80:61–65
  4. Juniper EF, Guyatt GH. Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis. Clin Exp Allergy. 1990;21:77–83
  5. Vuurman EPF, van Veggel LMA, Uiterwijk MMC, Leutner D, O'Hanlon JF. Seasonal allergic rhinitis and anti-histamine effects on childrens' learning. Ann Allergy. 1993;71:121–126
  6. Vuurman EPF, van Veggel LMA, Sanders RL, Muntjewerff ND, O'Hanlon JF. Effects of semprex-D and diphenhydramine on learning in young adults with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 1996;76:247–252
  7. Emberlin J, Mullins J, Corden J, Jones S, Millington W, Brooke M, et al. Regional variations in grass pollen seasons in the UK, long-term trends and forecast models. Clin Exp Allergy. 1999;29:347–356
  8. Warner JO. Seasonal rhinoconjunctivitis and examinations: is this unfair discrimination?. Paed Allergy Immunol. 2000;11:129–130
  9. Indices of deprivation 2000. Available at: http://www.statistics.gov.uk/StatBase/Product.asp?vlnk=9421&Pos=1&ColRank=2&Rank=272. Accessed May 30, 2007.
  10. UK Census 2001. Available at: http://www.statistics.gov.uk/census2001/pdfs/key_statistics_final.pdf. Accessed May 30, 2007.
  11. Harvey RP, Comer C, Sanders B, Westley R, Marsh W, Shapiro H, et al. Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis. J Allergy Clin Immunol. 1996;97:1233–1241
  12. European Parliament. Official journal L 121, 01/05/2001 P.0034-0044. 2001. Available at: http://europa.eu.int/eur-lex/lex/LexUriServ/LexUriServ.do?uri=CELEX:32001L0020:EN:HTML. Accessed March 22, 2007.
  13. Office of Public Sector Information. Data protection act. London: Stationary Office Ltd; 1998.
  14. A guide to trapping pollen and spores. British Aerobiology Federation; 1995.
  15. Ramaekers JG, Uiterwijk MM, O'Hanlon JF. Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving. Eur J Clin Pharmacol. 1992;42:363–369
  16. Mann RD, Pearce GL, Dunn N, Shakir S. Sedation with “non-sedating” antihistamines: four prescription-event monitoring studies in general practice. BMJ. 2000;320:1184–1186
  17. Yanai K, Ryu JH, Watanabe T, Iwata R, Ido T, Sawai Y, et al. Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography. Br J Pharmacol. 1995;116:1649–1655
  18. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108:s147–s333
  19. Simons FER. Drug therapy: advances in H1-antihistamines. N Engl J Med. 2004;351:2203–2217
  20. Kay GG, Berman B, Mockoviak SH, Morris CE, Reeves D, Starbuck V, et al. Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Arch Intern Med. 1997;157:2350–2356
  21. Lavie P, Gertner R, Zomer J, Podoshin L. Breathing disorders in sleep associated with “microarousals” in patients with allergic rhinitis. Acta Otolaryngol. 1981;92:529–533
  22. Storms WW. Treatment of allergic rhinitis: effects of allergic rhinitis and antihistamines on performance. Allergy Asthma Proc. 1997;18:59–61
  23. Stokes J, Fenstad E, Casale TB. Managing impairment in patients with allergic rhinitis. Allergy Asthma Proc. 2006;27:12–16
  24. American Academy of Allergy Asthma and Immunology. Task force on allergic disorders: promoting best practice: raising the standard of care for patients with allergic disorders. Milwaukee (WI): American Academy of Allergy, Asthma & Immunology; 1998.
  25. Blaiss M. Current concepts and therapeutic strategies for allergic rhinitis in school-age children. Clin Ther. 2004;26:1876–1889
  26. Department for Education and Skills. Youth cohort study: the activities and experiences of 16 year olds: England and Wales 2004. Available at: http://www.dfes.gov.uk/rsgateway/DB/SFR/s000560/index.shtml. Accessed March 22, 2007.
  27. Gibbons S. Geography, resources and primary school performance. London: London School of Economics and Political Science; 2002.

 Supported by a restricted grant from Schering-Plough UK.Disclosure of potential conflict of interest: S. Walker has consulting arrangements with and has received grant support from Schering-Plough. M. Fletcher has received grant support from GlaxoSmithKline, AstraZeneca, and Novartis. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)00632-X

doi: 10.1016/j.jaci.2007.03.034

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 2 , Pages 381-387 , August 2007