The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1 , Pages 137-143 , July 2007

Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma

  • Mariam Naqvi, BA

      Affiliations

    • From the University of California, San Francisco
  • ,
  • Shweta Choudhry, PhD, MSc

      Affiliations

    • From the University of California, San Francisco
  • ,
  • Hui-Ju Tsai, PhD

      Affiliations

    • From the University of California, San Francisco
  • ,
  • Shannon Thyne, MD

      Affiliations

    • From the University of California, San Francisco
  • ,
  • Daniel Navarro, MD

      Affiliations

    • From the University of California, San Francisco
  • ,
  • Sylvette Nazario, MD

      Affiliations

    • San Juan Veterans Affairs Medical Center, University of Puerto Rico School of Medicine
  • ,
  • Jose R. Rodriguez-Santana, MD

      Affiliations

    • Pediatric Pulmonary Program of San Juan
  • ,
  • Jesus Casal, MD

      Affiliations

    • San Juan Veterans Affairs Medical Center, University of Puerto Rico School of Medicine
  • ,
  • Alfonso Torres, MD

      Affiliations

    • San Juan Veterans Affairs Medical Center, University of Puerto Rico School of Medicine
  • ,
  • Rocio Chapela, MD

      Affiliations

    • Instituto Nacional de Enfermedades Respiratorias, Mexico City
  • ,
  • H. Geoffrey Watson, MD

      Affiliations

    • James A. Watson Wellness Center, Oakland
  • ,
  • Kelley Meade, MD

      Affiliations

    • Children's Hospital and Research Institute, Oakland
  • ,
  • William Rodriguez-Cintron, MD

      Affiliations

    • San Juan Veterans Affairs Medical Center, University of Puerto Rico School of Medicine
  • ,
  • Michael LeNoir, MD

      Affiliations

    • Bay Area Pediatrics, Oakland
  • ,
  • Pedro C. Avila, MD

      Affiliations

    • Northwestern University, Evanston
  • ,
  • Esteban González Burchard, MD, MPH

      Affiliations

    • From the University of California, San Francisco
    • Corresponding Author InformationReprint requests: Esteban Gonz´lez Burchard, MD, MPH, University of California, San Francisco, San Francisco, CA 94143-2911.

Received 27 September 2006 ,Revised 10 February 2007 ,Accepted 19 February 2007.

References 

  1. Sunyer J, Anto J, Castellsague J, Soriano J, Roca J. Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. Eur Respir J. 1996;9:1880–1884
  2. Freidhoff L, Marsh D. Relationship among asthma, serum IgE levels, and skin test reactivity to inhaled allergens. Int Arch Allergy Appl Immunol. 1993;100:355–361
  3. Burrows B, Martinez F, Halonen M, Barbee R, Cline M. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med. 1989;320:271–277
  4. Sears M, Burrows B, Flannery E, Herbison G, Hewitt C, Holdaway M. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med. 1991;325:1067–1071
  5. Sporik R, Ingram J, Price W, Sussman J, Honsinger R, Platts-Mills T. Association of asthma with serum IgE and skin test reactivity to allergens among children living at high altitude: tickling the dragon's breath. Am J Respir Crit Care Med. 1995;151:1388–1392
  6. Siroux V, Oryszczyn M-P, Paty E, Kauffmann F, Pison C, Vervolet D, et al. Relationships of allergic sensitization, total immunoglobulin E and blood eosinophils to asthma severity in children of the EGEA Study. Clin Exp Allergy. 2003;33:746–751
  7. Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2005;95:247-53.
  8. Annesi I, Oryszczyn M, Frette C, Neukirch F, Orvoen-Frija E, Kauffmann F. Total circulating IgE and FEV1 in adult men: an epidemiologic longitudinal study. Chest. 1992;101:642–648
  9. Limb S, Brown K, Wood R, et al. Adult asthma severity in individuals with a history of childhood asthma. J Allergy Clin Immunol. 2005;115:61–66
  10. Sunyer J, Anto JM, Sabria J, et al. Relationship between serum IgE and airway responsiveness in adults with asthma. J Allergy Clin Immunol. 1995;95:699–706
  11. Joseph CLM, Ownby DR, Peterson EL, Johnson CC. Racial differences in physiologic parameters related to asthma among middle-class children. Chest. 2000;117:1336–1344
  12. de Marco R, Marcon A, Jarvis D, et al. Prognostic factors of asthma severity: a 9-year international prospective cohort study. J Allergy Clin Immunol. 2006;117:1249–1256
  13. Ayres JG, Higgins B, Chilvers ER, Ayre G, Blogg M, Fox H. Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy. 2004;59:701–708
  14. Busse W, Corren J, Lanier BQ, et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001;108:184–190
  15. Soler M, Matz J, Townley R, et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J. 2001;18:254–261
  16. Asthma prevalence and control characteristics by race/ethnicity: United States, 2002. JAMA. 2004;291:1435–1436
  17. Burchard EG, Avila PC, Nazario S, et al. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004;169:386–392
  18. Davis AM, Kreutzer R, Lipsett M, King G, Shaikh N. Asthma prevalence in Hispanic and Asian American ethnic subgroups: results from the California Healthy Kids Survey. Pediatrics. 2006;118:e363–e370
  19. Lozano P, Connell FA, Koepsell TD. Use of health services by African-American children with asthma on Medicaid. JAMA. 1995;274:469–473
  20. Elster A, Jarosik J, VanGeest J, Fleming M. Racial and ethnic disparities in health care for adolescents: a systematic review of the literature. Arch Pediatr Adolesc Med. 2003;157:867–874
  21. Shields AE, Comstock C, Weiss KB. Variations in asthma care by race/ethnicity among children enrolled in a state Medicaid program. Pediatrics. 2004;113:496–504
  22. Lieu TA, Lozano P, Finkelstein JA, et al. Racial/ethnic variation in asthma status and management practices among children in managed Medicaid. Pediatrics. 2002;109:857–865
  23. Asthma mortality and hospitalization among children and young adults: United States, 1980-1993. MMWR Morb Mortal Wkly Rep. 1996;45:350–353
  24. Ray NF, Thamer M, Fadillioglu B, Gergen PJ. Race, income, urbanicity, and asthma hospitalization in California: a small area analysis. Chest. 1998;113:1277–1284
  25. Burchard EG, Avila PC, Nazario S, et al. Lower bronchodilator responsiveness in Puerto Rican than in Mexican asthmatic subjects. Am J Respir Crit Care Med. 2004;169:386-92
  26. Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis. 1978;118:1–120
  27. Federal Financial Institutions Examination Council geocoding/mapping system. Washington (DC): US Census Bureau; 2000;
  28. Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med. 1995;152:1107–1136
  29. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  30. Kitch BT, Paltiel AD, Kuntz KM, et al. A single measure of FEV1 is associated with risk of asthma attacks in long-term follow-up. Chest. 2004;126:1875–1882
  31. Enright PL, Johnson LR, Connett JE, Voelker H, Buist AS. Spirometry in the Lung Health Study, 1: methods and quality control. Am Rev Respir Dis. 1991;143:1215–1223
  32. Enright PL, Lebowitz MD, Cockroft DW. Physiologic measures: pulmonary function tests: asthma outcome. Am J Respir Crit Care Med. 1994;149:S9–S18discussion S19-S20
  33. Korotzer B, Ong S, Hansen JE. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Am J Respir Crit Care Med. 2000;161:1101–1108
  34. Ip MS, Karlberg EM, Karlberg JP, Luk KD, Leong JC. Lung function reference values in Chinese children and adolescents in Hong Kong, I: spirometric values and comparison with other populations. Am J Respir Crit Care Med. 2000;162:424–429
  35. Ip MS, Karlberg EM, Chan KN, Karlberg JP, Luk KD, Leong JC. Lung function reference values in Chinese children and adolescents in Hong Kong, II: prediction equations for plethysmographic lung volumes. Am J Respir Crit Care Med. 2000;162:430–435
  36. Azizi BH, Henry RL. Ethnic differences in normal spirometric lung function of Malaysian children. Respir Med. 1994;88:349–356

 Supported by the National Institutes of Health (R01 HL078885, K23 HL04464, HL07185, GM61390, American Lung Association of California, Robert Wood Johnson Amos Medical Faculty Development Award, National Center for Minority Health Disparities Health Disparities Scholar, Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds, 2001-2003, to E.G.B.), (HL51823, HL074204, 3M01RR000083-38S30488, HL56443, and HL51831 to the Asthma Clinical Research Network), an American Thoracic Society Breakthrough Opportunities in Lung Disease grant (ATS-05-078) and a Tobacco-Related Disease Research Program New Investigator Award (15KT-0008) to S.C., the American Lung Association of California (Research Training Fellowship to H.-J.T.), San Francisco General Hospital General Clinical Research Center M01RR00083-41, U01-HL 65899, University of California, San Francisco-Children's Hospital of Oakland Pediatric Clinical Research Center (M01 RR01271), Oakland, Calif, Sandler Center for Basic Research in Asthma, and the Sandler Family Supporting Foundation, Ernest S. Bazley Grant to Northwestern University.Disclosure of potential conflict of interest: M. LeNoir has consulting arrangements with GlaxoSmithKline and is on the speakers' bureau for GlaxoSmithKline, Aventis, and Alocon. P. C. Avila has received grant support from Genentech and Novartis. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)00614-8

doi: 10.1016/j.jaci.2007.02.045

The Journal of Allergy and Clinical Immunology
Volume 120, Issue 1 , Pages 137-143 , July 2007