« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 119, Issue 5 , Pages 1164-1173 , May 2007

Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort

Julie Rowe, PhD
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Merci Kusel, MBBS, PhD
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Barbara J. Holt, BSc
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Devinda Suriyaarachchi, BSc(Hons)
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Michael Serralha, BSc(Hons)
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Elysia Hollams, PhD
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Stephanie T. Yerkovich, PhD
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Lily S. Subrata, PhD
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Claire Ladyman, BSc
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Agata Sadowska, BSc(Hons)
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Jamie Gillett, BSc
- Princess Margaret Hospital for Children, Subiaco
Elizabeth Fisher, BSc
- Princess Margaret Hospital for Children, Subiaco
Richard Loh, FRACP
- Princess Margaret Hospital for Children, Subiaco
Lars Soderstrom, MSc
- Phadia AB, Uppsala
- Karolinska Institute, Stockholm
Staffan Ahlstedt, PhD
- Phadia AB, Uppsala
- Karolinska Institute, Stockholm
Peter D. Sly, MD, FRACP, DSc
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
Patrick G. Holt, DSc
- From the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth
- Reprint requests: Patrick G. Holt, DSc, Division of Cell Biology, Telethon Institute for Child Health Research, PO Box 855, West Perth WA 6872, Australia.

Received 14 November 2006 ,Revised 24 January 2007 ,Accepted 15 February 2007.

HDM-stimulated cytokine production. Data are shown as means + SEs for those who are HDM SPT–negative (open bars; n = 113, 117, 101, and 151 at birth, 6, 12, and 24 months) versus those who are HDM SPT

HDM-stimulated cytokine production. Data are shown as means + SEs for those who are HDM SPT–negative (open bars; n = 113, 117, 101, and 151 at birth, 6, 12, and 24 months) versus those who are HDM SPT–positive (gray bars; n = 33, 32, 34, and 43) at 24 months. Samples with 0 assay values are plotted here and below as 0.5 × detection limit. Differences between groups: ^∗P < .05; ^∗∗P < .01; ^∗∗∗P < .001.
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HDM-specific IgE and IgG4 titers. A, Antibody titers in subjects HDM SPT–negative at 24 months (circles; n = 171) or HDM SPT–positive (triangles; n = 47). Each X designates a median. B, Tracking antib

HDM-specific IgE and IgG₄ titers. A, Antibody titers in subjects HDM SPT–negative at 24 months (circles; n = 171) or HDM SPT–positive (triangles; n = 47). Each X designates a median. B, Tracking antibody titers in individuals who are HDM SPT–negative versus HDM SPT–positive at outcome age [differences between group (A) or individual titers (B) designated by asterisks as per Fig 1].
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Peanut-specific IgE and IgG4 titers. A, Antibody titers in subjects sensitized (peanut-specific IgE ≥ 0.35 kU/L; triangles; n = 18) versus nonsensitized (circles; n = 199) at 24 months. B, Tracking of

Peanut-specific IgE and IgG₄ titers. A, Antibody titers in subjects sensitized (peanut-specific IgE ≥ 0.35 kU/L; triangles; n = 18) versus nonsensitized (circles; n = 199) at 24 months. B, Tracking of antibody titers in individuals. Data expressed as per Fig 2.
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Phadiatop IgE and IgG4 titers. A, Phadiatop IgE and IgG4 titers in individuals stratified by atopic status at 24 months. SPT-positive response to any allergen in the test panel (triangles; n = 94); SP

Phadiatop IgE and IgG₄ titers. A, Phadiatop IgE and IgG₄ titers in individuals stratified by atopic status at 24 months. SPT-positive response to any allergen in the test panel (triangles; n = 94); SPT negatives (circles; n = 125). B, Tracking of Phadiatop titers in individuals. Data expressed as per Fig 2.
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Total IgE titers. A, IgE titers in the same subjects shown in Fig 4. B, tracking of total IgE titers in individuals. Data expressed as per Fig 2.

Total IgE titers. A, IgE titers in the same subjects shown in Fig 4. B, tracking of total IgE titers in individuals. Data expressed as per Fig 2.
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Supported by a grant from the National Health & Medical Research Council of Australia with supplementary support from the Food Allergy Initiative, New York.Disclosure of potential conflict of interest: L. Soderstrom and S. Ahlstedt are employed by Phadia AB, Uppsala, Sweden. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(07)00412-5

doi: 10.1016/j.jaci.2007.02.016

« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 119, Issue 5 , Pages 1164-1173 , May 2007