The Journal of Allergy and Clinical Immunology
Volume 119, Issue 4 , Pages 930-936 , April 2007

Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study

  • Aida Semic-Jusufagic, MD

      Affiliations

    • From the University of Manchester
    • Corresponding Author InformationReprint requests: Aida Semic-Jusufagic, MD, University of Manchester, North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, United Kingdom.
  • ,
  • Claus Bachert, MD, PhD

      Affiliations

    • University of Ghent
  • ,
  • Philippe Gevaert, MD

      Affiliations

    • University of Ghent
  • ,
  • Gabriele Holtappels, BSc

      Affiliations

    • University of Ghent
  • ,
  • Lesley Lowe, PhD

      Affiliations

    • From the University of Manchester
  • ,
  • Ashley Woodcock, MD, FRCP

      Affiliations

    • From the University of Manchester
  • ,
  • Angela Simpson, MD, MRCP

      Affiliations

    • From the University of Manchester
  • ,
  • Adnan Custovic, MD, PhD

      Affiliations

    • From the University of Manchester

Received 26 September 2006 ,Revised 12 December 2006 ,Accepted 14 December 2006.

References 

  1. Proft T, Fraser JD. Bacterial superantigens. Clin Exp Immunol. 2003;133:299–306
  2. Laouini D, Kawamoto S, Yalcindag A, Bryce P, Mizoguchi E, Oettgen H, et al. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003;112:981–987
  3. Heaton T, Mallon D, Venaille T, Holt P. Staphylococcal enterotoxin induced IL-5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse?. Allergy. 2003;58:252–256
  4. Lehmann HS, Heaton T, Mallon D, Holt PG. Staphylococcal enterotoxin-B-mediated stimulation of interleukin-13 production as a potential aetiologic factor in eczema in infants. Int Arch Allergy Immunol. 2004;135:306–312
  5. Breuer K, Kapp A, Werfel T. Bacterial infections and atopic dermatitis. Allergy. 2001;56:1034–1041
  6. Akiyama H, Toi Y, Kanzaki H, Tada J, Arata J. Prevalence of producers of enterotoxins and toxic shock syndrome toxin-1 among Staphylococcus aureus strains isolated from atopic dermatitis lesions. Arch Dermatol Res. 1996;288:418–420
  7. McFadden JP, Noble WC, Camp RD. Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol. 1993;128:631–632
  8. Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol. 1996;132:27–33
  9. Okano M, Takishita T, Yamamoto T, Hattori H, Yamashita Y, Nishioka S, et al. Presence and characterization of sensitization to staphylococcal enterotoxins in patients with allergic rhinitis. Am J Rhinol. 2001;15:417–421
  10. Riechelmann H, Essig A, Deutschle T, Rau A, Rothermel B, Weschta M. Nasal carriage of Staphylococcus aureus in house dust mite allergic patients and healthy controls. Allergy. 2005;60:1418–1423
  11. Shiomori T, Yoshida S, Miyamoto H, Makishima K. Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis. J Allergy Clin Immunol. 2000;105:449–454
  12. Bachert C, Gevaert P, Howarth P, Holtappels G, van Cauwenberge P, Johansson SG. IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma. J Allergy Clin Immunol. 2003;111:1131–1132
  13. Lee JH, Lin YT, Yang YH, Wang LC, Chiang BL. Increased levels of serum-specific immunoglobulin E to staphylococcal enterotoxin A and B in patients with allergic rhinitis and bronchial asthma. Int Arch Allergy Immunol. 2005;138:305–311
  14. Hauk PJ, Wenzel SE, Trumble AE, Szefler SJ, Leung DY. Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens. J Allergy Clin Immunol. 1999;104:37–45
  15. Zhang N, Gevaert P, van Zele T, Perez-Novo C, Patou J, Holtappels G, et al. An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis. Rhinology. 2005;43:162–168
  16. Custovic A, Simpson BM, Murray CS, Lowe L, Woodcock A. The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol. 2002;13(suppl 15):32–37
  17. Lowe L, Murray CS, Custovic A, Simpson BM, Kissen PM, Woodcock A. Specific airway resistance in 3-year-old children: a prospective cohort study. Lancet. 2002;359:1904–1908
  18. Pearce N, Weiland S, Keil U, Langridge P, Anderson HR, Strachan D, et al. Self-reported prevalence of asthma symptoms in children in Australia, England, Germany and New Zealand: an international comparison using the ISAAC protocol. Eur Respir J. 1993;6:1455–1461
  19. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995;332:133–138
  20. Dab I, Alexandar F. A simplified approach to the measurement of specific airway resistance. Paediatr Res. 1976;10:998–999
  21. Klug B, Bisgaard H. Measurement of the specific airway resistance by plethysmography in young children accompanied by an adult. Eur Respir J. 1997;10:1599–1605
  22. Perez-Novo CA, Claeys C, van Zele T, Holtappels G, van Cauwenberge P, Bachert C. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. Am J Rhinol. 2006;20:456–460
  23. Hellings PW, Hens G, Meyts I, Bullens D, Vanoirbeek J, Gevaert P, et al. Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B. Clin Exp Allergy 2006;36:1063-71.
  24. Cardona ID, Goleva E, Ou LS, Leung DY. Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J Allergy Clin Immunol. 2006;117:688–695
  25. Rohde G, Gevaert P, Holtappels G, Borg I, Wiethege A, Arinir U, et al. Inceased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD. Respir Med. 2004;98:858–864
  26. Herz U, Ruckert R, Wollenhaupt K, Tschering T, Neuhaus-Steinmetz U, Pabst R, et al. Airway exposure to bacterial superantigen (SEB) induces lymphocyte-dependent airway inflammation associated with increased airway responsiveness: a model for non-allergenic asthma. Eur J Immunol. 1999;29:1021–1031
  27. Breuer K, Wittmann M, Bosche B, Kapp A, Werfel T. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy. 2000;55:551–555
  28. Breuer K, HAussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol. 2002;147:55–61
  29. Novak N, Allam JP, Bieber T. Allergic hyperreactivity to microbial components: a trigger factor of “intrinsic” atopic dermatitis?. J Allergy Clin Immunol. 2003;112:215–216

 Supported by Asthma UK grant #04/014 and a grant from the Flemish Scientific Research Board, Fonds voor Wetenschappelijk Onderzoek, Nr A12/5-K/V-K17.Disclosure of potential conflict of interest: All of the authors have received grant support from Asthma UK and the Flemish Scientific Research Board.

PII: S0091-6749(06)03908-X

doi: 10.1016/j.jaci.2006.12.639

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 4 , Pages 930-936 , April 2007