The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 731-738 , March 2007

Pediatric patients with eosinophilic esophagitis: An 8-year follow-up

  • Amal H. Assa'ad, MD

      Affiliations

    • From the Division of Allergy and Immunology
    • Corresponding Author InformationReprint requests: Amal H. Assa'ad, MD, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2000, Cincinnati, OH 45229.
    • ,
  • Philip E. Putnam, MD

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition
    • ,
  • Margaret H. Collins, MD

      Affiliations

    • Division of Pathology
    • ,
  • Rachel M. Akers, MPH

      Affiliations

    • Division of Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center
    • ,
  • Sean C. Jameson

      Affiliations

    • From the Division of Allergy and Immunology
    • ,
  • Cassie L. Kirby

      Affiliations

    • From the Division of Allergy and Immunology
    • ,
  • Bridget K. Buckmeier

      Affiliations

    • From the Division of Allergy and Immunology
    • ,
  • Jennifer Z. Bullock, MD

      Affiliations

    • From the Division of Allergy and Immunology
    • ,
  • Ann R. Collier, MD

      Affiliations

    • From the Division of Allergy and Immunology
    • ,
  • Michael R. Konikoff, MD

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition
    • ,
  • Richard J. Noel, MD, PhD

      Affiliations

    • Division of Gastroenterology and Nutrition, Medical College of Wisconsin and Children's Hospital of Wisconsin
    • ,
  • Jesus R. Guajardo, MD, MHPE

      Affiliations

    • Pulmonary/Allergy, Child Health, University of Missouri
    • ,
  • Marc E. Rothenberg, MD, PhD

      Affiliations

    • From the Division of Allergy and Immunology

Received 13 June 2006 ,Revised 13 October 2006 ,Accepted 23 October 2006.

References 

  1. Kaijser R. Zur Kenntnis der allergischen Affektionen des Verdauungskanals vom Standpunkt des Chirurgen aus. Arch Klin Chir. 1937;188:36–64
  2. Hoefer RA, Ziegler MM, Koop CE, Schnaufer L. Surgical manifestations of eosinophilic gastroenteritis in the pediatric patient. J Pediatr Surg. 1977;12:955–962
  3. Steffen RM, Wyllie R, Petras RE, Caulfield ME, Michener WM, Firor HV, et al. The spectrum of eosinophilic gastroenteritis: report of six pediatric cases and review of the literature. Clin Pediatr (Phila). 1991;30:404–411
  4. Whitington PF, Whitington GL. Eosinophilic gastroenteropathy in childhood. J Pediatr Gastroenterol Nutr. 1988;7:379–385
  5. Melamed I, Feanny SJ, Sherman PM, Roifman CM. Benefit of ketotifen in patients with eosinophilic gastroenteritis. Am J Med. 1991;90:310–314
  6. Katz AJ, Twarog FJ, Zeiger RS, Falchuk ZM. Milk-sensitive and eosinophilic gastroenteropathy: similar clinical features with contrasting mechanisms and clinical course. J Allergy Clin Immunol. 1984;74:72–78
  7. Sun HL, Lue KH. Eosinophilic gastroenteritis in children-report of one case. Asian Pac J Allergy Immunol. 2001;19:221–223
  8. Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109:1503–1512
  9. Liacouras CA, Wenner WJ, Brown K, Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr. 1998;26:380–385
  10. Orenstein SR, Shalaby TM, Di Lorenzo C, Putnam PE, Sigurdsson L, Mousa H, et al. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol. 2000;95:1422–1430
  11. Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol. 1999;2:15–18
  12. Debrosse CW, Case JW, Putnam PE, Collins MH, Rothenberg ME. Quantity and distribution of eosinophils in the gastrointestinal tract of children. Pediatri Develop Pathol. 2006;9:210–218
  13. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Listrom MB, Rilke FO. The normal anatomy of the esophagus. In: Gastrointestinal pathology: an atlas and text. Philadelphia: Lippincott-Raven; 1999;p. 15–29
  14. Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3:1198–1206
  15. Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343
  16. Vanderhoof JA, Young RJ, Hanner TL, Kettlehut B. Montelukast: use in pediatric patients with eosinophilic gastrointestinal disease. J Pediatr Gastroenterol Nutr. 2003;36:293–294
  17. Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98:777–782
  18. Teitelbaum JE, Fox VL, Twarog FJ, Nurko S, Antonioli D, Gleich G, et al. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002;122:1216–1225
  19. De Agustin JC, Sanz N, Canals MJ, Alvarez E, Morales JL, Soler J, et al. Successful medical treatment of two patients with eosinophilic oesophagitis. J Pediatr Surg. 2002;37:207–213
  20. Faubion WA, Perrault J, Burgart LJ, Zein NN, Clawson M, Freese DK. Treatment of eosinophilic esophagitis with inhaled corticosteroids. J Pediatr Gastroenterol Nutr. 1998;27:90–93
  21. Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier BK, et al. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006;131:1381–1391
  22. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125:1660–1669

 Supported by a 2005 American Academy of Allergy, Asthma & Immunology/Sanofi Aventis Women Physicians in Allergy Project Grant Award (A.H.A.) and a 2004 American Academy of Allergy, Asthma & Immunology Clinical Fellowship Award (J.Z.B.).Disclosure of potential conflict of interest: A. H. Assa'ad has consulting arrangements with and has received grant support from GlaxoSmithKline. M. H. Collins has consulting arrangements with GlaxoSmithKline and Ception Therapeutics. R. J. Noel has consulting arrangements with Ception Therapeutics. M. E. Rothenberg has consulting arrangements with GlaxoSmithKline, Ception Therapeutics, Cambridge Antibody Technology, Tanox, and MedaCorp; owns stock in Ception Therapeutics; has received grant support from Cambridge Antibody Technology; and is on the speakers' bureau for Merck. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(06)03792-4

doi: 10.1016/j.jaci.2006.10.044

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 731-738 , March 2007

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