The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 697-704 , March 2007

Cat and dust mite allergen levels, specific IgG and IgG4, and respiratory symptoms in adults

  • Deborah Jarvis, MD

      Affiliations

    • From the Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, London
    • Corresponding Author InformationReprint requests: Deborah Jarvis, MD, Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Emmanuel Kaye Building, Manresa Road, London SW3 6LR.
  • ,
  • Jan-Paul Zock, PhD

      Affiliations

    • Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona
  • ,
  • Joachim Heinrich, PhD

      Affiliations

    • Institute of Epidemiology, GSF—National Research Center for Environment and Health, Neuherberg
  • ,
  • Cecilie Svanes, MD

      Affiliations

    • Department of Medicine, Department of Thoracic Medicine, Haukeland Hospital, Bergen
  • ,
  • Giuseppe Verlato, MD

      Affiliations

    • Unit of Epidemiology and Medical Statistics
  • ,
  • Mario Olivieri, MD

      Affiliations

    • Unit of Occupational Medicine, Department of Medicine and Public Health, University of Verona
  • ,
  • Simona Villani, PhD

      Affiliations

    • Section of Medical Statistics and Epidemiology, Department of Health Sciences, University of Pavia
  • ,
  • Michela Ponzio, PhD

      Affiliations

    • Section of Medical Statistics and Epidemiology, Department of Health Sciences, University of Pavia
  • ,
  • Benedicte Leynaert, PhD

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale U700—Epidémiologie, Faculté de Médecine Xavier Bichat, Paris
  • ,
  • Jordi Sunyer, MD

      Affiliations

    • Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona
    • Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy at Göteborg University
    • Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona
  • ,
  • Anna Dahlman-Hoglund, PhD

      Affiliations

    • Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy at Göteborg University
  • ,
  • Susan Chinn, DSc

      Affiliations

    • Department of Public Health Sciences, King's College London
  • ,
  • Christina Luczynska, PhD

      Affiliations

    • Deceased.
  • ,
  • Dan Norbäck, PhD

      Affiliations

    • Department of Medical Science, Occupational and Environmental Medicine, Uppsala University
  • ,
  • Peter Burney, MD

      Affiliations

    • From the Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, London

Received 16 May 2006 ,Revised 21 September 2006 ,Accepted 24 October 2006.

References 

  1. Jenmalm MC, Bjorksten B. Development of immunoglobulin G subclass antibodies to ovalbumin, birch and cat during the first eight years of life in atopic and non-atopic children. Pediatr Allergy Immunol. 1999;10:112–121
  2. Kemeny DM, Urbanek R, Ewan PW, McHugh S, Richards D, Patel S, et al. The subclass of IgG antibody in allergic disease, II: the IgG subclass of antibodies produced following natural exposure to dust mite and grass pollen in dust mite and grass pollen in atopic and non-atopic individuals. Clin Exp Allergy. 1989;19:545–549
  3. Lau S, Illi S, Platts-Mills T, Riposo D, Nickel R, Gruber C, et al. Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat specific IgG and development of asthma in childhood: report of the German Multicentre Allergy Study (MAS 90). Allergy. 2005;60:766–773
  4. Aalberse RC, van der GR, van LJ. Serologic aspects of IgG4 antibodies, I: prolonged immunization results in an IgG4-restricted response. J Immunol. 1983;130:722–726
  5. Gehlar K, Schlaak M, Becker W, Bufe A. Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen specific IgG4 and IgG1 correlates with clinical outcome. Clin Exp Allergy. 1999;29:497–506
  6. Witteman AM, Stapel SO, Sjamsoedin DH, Jansen HM, Aalberse RC, der Zee JS. Fel d 1-specific IgG antibodies induced by natural exposure have blocking activity in skin tests. Int Arch Allergy Immunol. 1996;109:369–375
  7. Aalberse RC, Van Milligen F, Tan K, Stapel SO. Allergen-specific IgG4 in atopic disease. Allergy. 1993;48:559–569
  8. Hussain R, Grogl M, Ottesen E. IgG antibody subclasses in human filariasis. J Immunol. 1987;139:2794–2798
  9. Hussain R, Poindexter R, Ottesen E. Control of allergic reactivity in human filariasis. J Immunol. 1992;148:2731–2737
  10. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet. 2001;357:752–756
  11. Hesselmar B, Aberg B, Eriksson B, Bjorksten B, Aberg N. High dose exposure to cat is associated with clinical tolerance: a modified TH2 immune response. Clin Exp Allergy. 2003;33:1681–1685
  12. Aalberse R, Platts-Mills T. How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective. J Allergy Clin Immunol. 2004;113:983–986
  13. European Community Respiratory Health Survey. Protocol for the European Community Respiratory Health Survey. London: United Medical and Dental Schools of Guy's and St Thomas's Hospitals, Department of Public Health Medicine; 1993.
  14. Burney P, Luczynska C, Chinn S, Jarvis D. The European Community Respiratory Health Survey. Eur Respir J. 1994;7:954–960
  15. European Community Respiratory Health Survey II Steering Committee . The European Community Respiratory Health Survey II. Eur Respir J. 2002;20:1071–1079
  16. Luczynska CM, Li Y, Chapman MD, Platts-Mills TAE. Airborne concentrations and particle size distribution of allergen derived from domestic cats (Felis domesticus): measurements using a cascade impactor, liquid impinger and a two site monoclonal antibody for Fel d 1. Am Rev Respir Dis. 1990;141:361–367
  17. Luczynska CM, Arruda LK, Platts-Mills TA, Miller JD, Lopez M, Chapman MD. A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989;118:227–235
  18. Zock JP, Heinrich J, Jarvis D, Verlato G, Norback D, Plana E, et al. Distribution and determinants of house dust mite allergen in Europe: The European Community Respiratory Health Survey II. J Allergy Clin Immunol. 2006;118:682–690
  19. International Labour Office G . International Standard Classification of Occupations (ISCO-88). Geneva: International Labour Office; 1990;
  20. Der Simonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  21. STATA statistical software, release 9. College Station (TX): Statacorp LP; 2005;
  22. Chinn S, Jarvis D, Burney P, Luczynska C, Ackermann-Liebrich U, Anto JM, et al. Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey. Thorax. 2004;59:646–651
  23. Portengen L, de Meer G, Doekes G, Heederik D. Immunoglobulin G4 antibodies to rat urinary allergens, sensitization and symptomatic allergy in laboratory animal workers. Clin Exp Allergy. 2004;34:1243–1250
  24. Uitti J, Nordman L, Halmepuro L, Savolainen J. IgG4 response to fur animal allergens among fur workers. Int Arch Occup Environ Health. 2005;78:71–74
  25. Custovic A, Hallam C, Simpson B, Craven M, Simpson A, Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol. 2001;108:537–539
  26. Erwin EA, Wickens K, Custis NJ, Siebers R, Woodfolk J, Barry D, et al. Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens. J Allergy Clin Immunol. 2005;115:74–79
  27. Waser M, von Mutius E, Riedler J, Nowak D, Maisch S, Carr D, et al. Exposure to pets and the association with hay fever, asthma, and atopic sensitization in rural children. Allergy. 2005;60:177–184
  28. McSharry C, Anderson K, McKay I, Colloff M, Feyerabend C, Wilson R. The IgE and IgG antibody responses to aerosols of Nephrops norvegicus (prawn) antigens: the association with clinical hypersensitivity and with cigarette smoking. Clin Exp Immunol. 1994;97:499–504

 The coordination of ECRHS II was supported by the European Commission as part of their Quality of Life program. For funders of the data collection in each center, please see this article's Online Repository at www.jacionline.org.Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(06)02361-X

doi: 10.1016/j.jaci.2006.10.042

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 697-704 , March 2007