The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 746-747 , March 2007

Contamination of probiotic preparations with milk allergens can cause anaphylaxis in children with cow's milk allergy

  • Tzu-Tai Tiger Lee, PhD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • ,
  • Martine Morisset, MD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy
    • ,
  • Catherine Astier, PhD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • JE2482 Lipidomix, MTM, Vandoeuvre-lès-Nancy, France
    • ,
  • Denise-Anne Moneret-Vautrin, MD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy
    • ,
  • Vanina Cordebar, MD

      Affiliations

    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy
    • ,
  • Etienne Beaudouin, MD

      Affiliations

    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy
    • ,
  • Fanny Codreanu, MD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy
    • ,
  • Bernard E. Bihain, MD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • JE2482 Lipidomix, MTM, Vandoeuvre-lès-Nancy, France
    • ,
  • Gisèle Kanny, MD, PhD

      Affiliations

    • From EA3999 Allergic Diseases: Diagnosis and Therapeutics, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy
    • Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy

References 

  1. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2006;117(suppl 2):S470–S475
  2. FAO/WHO . Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Cordoba, Argentina: Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report; 2001;p. 1-34
  3. Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997;99:179–185
  4. Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial. Lancet. 2003;361:1869–1871
  5. Prescott SL, Dunstan JA, Hale J, Breckler L, Lehmann H, Weston S, et al. Clinical effects of probiotics are associated with increased interferon-γ responses in very young children with atopic dermatitis. Clin Exp Allergy. 2005;35:1557–1564
  6. Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy. 2005;60:494–500
  7. Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. Is the effect of probiotics on atopic dermatitis confined to food sensitized children?. Clin Exp Allergy. 2006;36:629–633
  8. Bjorksten B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol. 2001;108:516–520
  9. Moneret-Vautrin DA, Morisset M, Cordebar V, Codreanu F, Kanny G. Probiotics may be unsafe in infants allergic to cow's milk. Allergy. 2006;61:507–508

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(06)02356-6

doi: 10.1016/j.jaci.2006.11.011

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 3 , Pages 746-747 , March 2007

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